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A Golden Era of Cell-Assisted Fitness

A Golden Era of Cell-Assisted Fitness

A Golden Era of Cell-Assisted Fitness

In Oct 2021, Mary Grace, a 58-year-old adventurer, retraumatized her left knee trekking the Himalayas. Until then, she had surmounted a hospitalizing concussion, sports injuries, constant pain, brain fog, and chronic fatigue to scale new heights. But this incident was different – an air ambulance brought her down the mountain.

Mary Grace exercised her Right to Try AMBROSE Cell Therapy six weeks later. Her two-year patient-reported outcome demonstrates that a Golden Era of Cell-Assisted Fitness has begun.

Over the 24 months following her single Ambrose treatment, Mary Grace resumed hiking, skiing, and open-water swimming in Mexico – against the tide, no less. She took up windsurfing alongside whales, too.

Her training culminated with hiking 75 miles of the Appalachian Trail with a backpack and sleeping in a tent – without injury or relapse.

Here, we tie Mary Grace’s downfall to an unsuspected culprit and explain how her adipose-derived regenerative cells (ADRCs) started her climb back to extraordinary fitness levels. Or, as she says, “I am doing more than I ever had before.”

 Tiger’s Travails

In contrast to Mary Grace’s return to fitness, too many elite athletes like Tiger Woods, fitness fanatics, and weekend warriors resort to surgery, drugs, and devices (the standard of care). But they find themselves resigned to living with limitations and pain.   More on Tiger’s road to retirement despite access to the best surgeons fame can buy later. First, what led to Mary Grace’s fall from grace?

Over Training Syndrome – Too Fit?

Mary Grace’s exercise program embraced the five pillars of physical fitness: (1) body composition, (2) flexibility, (3) muscular strength, (4) muscular endurance, and (5) cardiorespiratory endurance.

Mary Grace should have been a pillar of health as she approached her sixties, a pivotal point in healthspan.  However, her love of demanding sports resulted in overtraining syndrome (OTS).

More than 90 years ago, physiologists recognized that sustained, intense training reduces athletic performance by perturbing multiple body systems.

Mary Grace’s arthritic shoulder, painful knees, hips, elbow, neck, back, and feet were the tip of the OTS iceberg. Chronic fatigue, injury proneness, burnout, and brain fog are part and parcel of this sparsely discussed but common condition.[1] 

Adventurous Meets Risk Adverse

For Mary Grace, going under the knife was not worth the risk. As she put it, “I have been in the healthcare business my whole career. No way would I get surgery or joint replacements.” As for giving up on adventure, she stated, “I am too young to grow old.”

Mary Grace knew there was a better option. Her husband, Thomas, accessed his ADRCs for a 25-year-old knee injury with Ambrose’s predecessor group in 2016. He had extensive scar damage from his 1991 orthoscopic surgery. Prior to Ambrose, his doctor recommended a knee replacement and shoulder surgery to repair a torn rotator cuff.

After his ADRC-based protocol, Thomas returned to walking, losing 25 pounds in short order.  Seven years out, Thomas functions fine with his own knee. His shoulder gets a little stiff from time to time, but he works it out with some exercise.

The Autonomic Nervous System – Hanging Fitness in the Balance

The autonomic nervous system (ANS) works without our conscious direction; hence, it is “autonomous.”

The ANS controls inflammation, immune regulation, blood pressure, bladder and bowel function, the gut microbiome, and more. [2]

Working out too hard or for too long imbalances the autonomic nervous system, regardless of how “fit” the person appears. Contrary to popular belief, fitness fanatics get sick more often and are more prone to autoimmune disorders than people in the Blue Zones who garden, walk, and socialize with friends.[3] [4]

A go-go-go life, Covid, Epstein-Barr Virus (mononucleosis), and Lyme Disease infections can have an “overtraining” effect as well.  [5] [6] [7]

Just as Buddha found Nirvana in Nepal, restoring autonomic nervous system (ANS) balance leads to the Nirvana of Health: multisystem balance or homeostasis.

The Autonomic Nervous System Two Divisions.

Sympathetic Division: 

  • Mary Grace thrives on open water swimming in Puerto Vallarta. But when she spotted a hammerhead shark, her sympathetic nervous system went into action. Her blood pressure increased, her heartbeat elevated, and her digestion slowed.

Parasympathetic Division

  • When Mary Grace finishes swimming with the whales, she chills with her husband and friends. Here, the parasympathetic nervous system plays a rest and digest tune. Relaxation and laughter set in. The sympathetic nervous system calms down. [8]

Vagus Nerve

The vagus nerve is our physiology’s fitness coach.  It guides the brain’s connections with the spine, heart, lungs, kidneys, and gut. The VN transitions the autonomic nervous system from stress to rest and back again as appropriate.

When Mary Grace’s sympathetic nervous system was overactivated, her parasympathetic nervous system and vagus nerve underperformed.

A hyperactive sympathetic response raises cortisol and adrenaline levels, lighting the inflammation fire. Then, the immune system throws gas on the flames, resulting in autoimmune diseases. [9]

Parasympathetic underactivity or reduced vagal tone contributes to depression, brain fog, fatigue, insomnia, and weakness. It’s like resting when you don’t want to and not being able to sleep when you need to. [10]

ADRCs Restore ANS Function and Vagal Tone

In 2017, researchers at Houston Methodist documented significant ANS improvements in two patients with autonomic dysfunction (dysautonomia)/ after a single autologous adipose-derived stem cell (ADSC) infusion.

The post-treatment follow-up studies showed:

  • Increased vagal tone
  • Stabilized blood pressure and heart rates
  • Improved circulation in the brain
  • Reduced Inflammatory markers [11]

Mary Grace’s revived mental clarity, energy, and lack of pain indicate her ADRCs restored enduring ANS function.

Tiger’s Travails

In contrast to Mary Grace’s near pain-free turnaround, Tiger Woods epitomizes the risks of excessive training and relying on surgeries, followed by medications, to manage his pain and depression.

  • In 1994, when he was just 18 years old, a surgeon removed two benign tumors and scar tissue from his left knee. Over the next 27 years, he had five back surgeries, four more knee operations, recurrent Achilles tendon tears, and a neck strain.
  • In May 2017, police arrested Tiger on suspicion of driving under the influence. A toxicology report revealed: Two opioids, Vicodin and Dilaudid, a benzodiazepine, Xanax, that induces feelings of calm (anxiolysis), drowsiness, and sleep, Ambien, a “z-drug” for sleep, and a cannabinoid, THC, for pain, according to com.
  • In 2022, a catastrophic car crash nearly killed him, requiring several life-saving surgeries. His doctors operated on him two more times after that. [12]

Ironically, when Mary Grace resumed training for the Appalachian trail, Tiger withdrew from the Hero World Challenge due to plantar fasciitis in November 2022. He was walking too much, a telling sign of how far his fitness had fallen.

At the 2023 Masters, Tiger Woods, in last place, withdrew before play resumed on Sunday due to injury. He told fans this was probably his last attempt at another Green Jacket.

During the same week, Mary Grace described her Appalachian trail training, “I hiked backward and up steep hills. I swam against the tide for a half mile, returned, and swam back against the tide. I bounce back faster. I couldn’t even do that when I was younger.”

While Mary Grace is not a world-class competitive athlete, the comparison holds. Few women have adventured to so many places in so many ways as her.

Mary Grace is just getting started—

And while Tiger continues to suffer, Mary Grace says, “I didn’t realize how much pain I was in until I wasn’t in it anymore.”

Published studies, including over 80 Celution System peer-reviewed papers, support Mary Grace’s conclusion: “After my stem cell treatment, I feel sharper and have better energy. I feel great and am doing more than I have ever done.” [13] [14].[15] [16] [17] [18]

[1] Armstrong LE et al. (2022) Overtraining Syndrome as a Complex Systems Phenomenon. Front. Netw. Physiol. 1:794392.

[2] Bellocchi C et al. The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases. Int J Mol Sci. 2022 Feb 23;23(5):2449.

[3] Kajaia T et al. THE EFFECTS OF NON-FUNCTIONAL OVERREACHING AND OVERTRAINING ON AUTONOMIC NERVOUS SYSTEM FUNCTION IN HIGHLY TRAINED ATHLETES. Georgian Med News. 2017 Mar;(264):97-103.

[4] Leal A et al. ‘Inflammation and Autonomic Function’, Autonomic Nervous System. InTech, Oct. 24, 2018.

[5] Lehmann, M. (1998). Autonomic Imbalance Hypothesis and Overtraining Syndrome. Med. Sci. Sports Exerc. 30 (7), 1140–1145.9

[6] Kreher JB, Schwartz JB. Overtraining Syndrome: A Practical Guide. Sports Health. 2012;4(2):128-138.

[7] Acanfora, D et al. Impaired Vagal Activity in Long-COVID-19 Patients. Viruses 2022, 14, 1035.

[8] Pavlov VA, Tracey KJ. The vagus nerve and the inflammatory reflex–linking immunity and metabolism. Nat Rev Endocrinol. 2012 Dec;8(12):743-54.

[9] Bellocchi C et al. The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases. Int J Mol Sci. 2022 Feb 23;23(5):2449.

[10] Shinba T et al. Major Depressive Disorder and Chronic Fatigue Syndrome Show Characteristic Heart Rate Variability Profiles Reflecting Autonomic Dysregulations: Differentiation by Linear Discriminant Analysis. Sensors (Basel). 2023 Jun 4;23(11):5330.

[11] Numan M et al. Autologous Adipose Stem Cell Therapy for Autonomic Nervous System Dysfunction in Two Young Patients STEM CELLS AND DEVELOPMENT Volume 26, Number 6, 2017

[12] https://bleacherreport.com/articles/2727452-tiger-woods-toxicology-report-reveals-5-drugs-in-his-system-during-dui-arrest  https://www.therecoveryvillage.com/drug-addiction/tiger-woods-dui-prescription-drugs/

[13] Vaquero J, et al. Progressive increase in brain glucose metabolism after intrathecal administration of autologous mesenchymal stromal cells in patients with diffuse axonal injury. Cytotherapy. 2017 Jan;19(1):88-94.

[14] Bonsack B, Corey S, Shear A, et al. Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury. CNS Neurosci Ther. 2020;26:603–615.

[15] Mosser DM, Hamidzadeh K, Goncalves R. Macrophages and the maintenance of homeostasis. Cell Mol Immunol. 2021 Mar;18(3):579-587.

[16] Vizoso FJ et al. Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities. Int J Mol Sci. 2019 Jul 31;20(15):3738.

[17] Naik S et al. Two to Tango: Dialog between Immunity and Stem Cells in Health and Disease. Cell. 2018 Nov 1;175(4):908-920. 

[18] Kallal N et al. “Regulation of autoimmune‐mediated neuroinflammation by endothelial cells.” European Journal of Immunology (2024): 2350482.

AMBROSE Cell Therapy

Your Right to Try

Ambrose Cell Therapy Physicians and Facility

Ambrose Cell Therapy Physicians and Facility

Ambrose Cell Therapy Physicians and Facility

Ambrose Cell Therapy, Inc is a management service organization that manages Ambrose Physician Services, PC.

Ambrose Physician Services doctors include:

Dr. Ram Dandillaya, Medical Director, Dr. Ram Dandillaya is the Clinical Chief in the Division of Cardiology at the Cedars-Sinai Medical Center. Dr. Dandillaya clears patients for liposuction unless they choose to do so with their local PCP.

Dr. Nitesh Patel, Attending Physician and Regenerative Injection Specialist, completed a fellowship in interventional pain management at the prestigious Stanford University Medical Center. Dr. Patel requests that patients provide any available recent imaging reports and do a telemedicine consult prior to the procedure.

Dr. Walter Joseph, Plastic Surgeon, completed his residency at the renowned University of Pittsburgh Medical Center. Dr. Joseph requests that patients schedule a telemedicine pre-op with his office.

Dr. Cheryl Jones, Patient Educator, has 25 years of family medicine experience. Her hat is to 1) educate patients so they can make an informed choice and 2) take a brief medical history upon which we will base a preliminary treatment for the patient’s consideration. Dr. Patel finalizes the treatment plan with the patient at the point of care.

Ambrose’s treatments are done at the Illuma Surgery Center, a AAAHC-accredited surgery center in Beverly Hills, CA.

120 Spalding Dr., Suite 205
Beverly Hills, CA 90212
310 975 4586

AMBROSE Cell Therapy

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What Do Umbilical Cord Stem Cells and Tide Pods Have in Common

What Do Umbilical Cord Stem Cells and Tide Pods Have in Common

What Do Umbilical Cord Stem Cells and Tide Pods Have in Common

“People often ask if stem cells work. Of course, they work. We are all walking stem cell products – the sperm, and the egg,” the revered James Willerson, MD, Ph.D. said in a talk in 2011.[1]

The Tide Pod Teenage Eating Fad, Gronk, and Reverse Psychology
What do dentists, chiropractors, anti-aging doctors, the Four Seasons Maui Spa, and the Tide Pods Eating Fad Have in Common?

In 2018, the Teenagers Eating Tide Pods Fad resulted in 10 deaths and 37 reported poison cases.

Proctor and Gamble, Tide’s manufacturer, went on the offensive to protect kids from poisoning themselves.

They even hired NFL superstar Rob Gronkowski to come from behind in the clutch as he had done to win four Super Bowls with Tom Brady. However, Gronk’s YouTube Tide Pod admonishment resulted in more teens taking the challenge.

Contamination, the FDA, and Reverse Psychology
On December 5, 2019,  the FDA warned Liveyon Labs, Inc. that they were selling unapproved, contaminated umbilical cord stem cell products. At least 300 patients had reported bacterial infections tied to Liveyon’s umbilical cord stem cell products.

One day later, the agency issued a press release informing manufacturers, providers, and the public of Liveyon’s issues and the broader scope of their concerns. The other recipients were RichSource Stem Cells, Inc., Chara Biologics, Inc., and R3 Stem Cell, LLC. In total, FDA issued  350 warning letters to manufacturers, healthcare providers, and clinics.

The result: Increasingly, chiropractors, dentists, naturopaths, integrative doctors, infusion clinics, orthopedists, and so on treat patients with unapproved, potentially contaminated, dead stem cells.

Who Killed the Stem Cells
Sadly, as a chiropractor’s patient with long-Covid and congestive heart failure related, “I tried umbilical cord stem cells. They didn’t work.” There were no live stem cells in the product with which he was treated or other commercially available perinatal vials, studies revealed:

  • Cell viability in the cord blood product was less than reported by the manufacturer, the cells were primarily leukocytes, no stem cells were present…”[2]
  • The aggressive marketing approach currently used by practitioners and clinics regarding various birth tissue products as safe and effective “stem cell therapy” is not supported by the existing scientific literature. [3]
  • CFU-Fs, often referred to as stem cells, were not found within any of the commercial UC (umbilical cord) allograft products analyzed, and clinicians should remain wary of marketing claims stating otherwise. [4]
  • Amniotic fluid has been proposed as an allogenic means for introducing MSCs. This study was unable to confirm that commercial AFPs (amniotic fluid products) contain MSCs. [5]

Risk Appetite
But how does the Tide Pod eating fad relate to the umbilical cord stem cell fad? The Tide Pod teenagers and Umbilical Cord Stem Cell (UBSC) patients share an appetite for risk:

  • The more Proctor and Gamble warned kids of the danger of eating Tide Pods, the faster the fad grows.
  • The more FDA warns providers and patients of perinatal stem cells and their exosomes’ risks, the more the fad is becoming a frenzy too.

A 2016 study identified 351 businesses promoting stem cell treatments. Five years later, the same author, estimated more than four times as many businesses (1,480) sell stem cell treatments, approximately half of which (781) promote umbilical, amniotic, or exosome treatments. [6]

More on risk-taking later. First, what are “perinatal stem cells”?

Perinatal Stem Cells
Perinatal refers to just before or shortly after birth. Thus, perinatal stem cells come from birth tissues or fluids, i.e., umbilical cord blood and tissue, placental blood and tissue, and amniotic tissue and fluid.

That sounds good on the surface, but as explained in The Cell Source Debate, mesenchymal stem cells (MSCs) are rare in birth tissues and fluid. There is more to that part of the story to follow.

Exosomes
Cells release tiny sacs or vesicles called exosomes. Like carrier pigeons, exosomes carry messages to nearby cells.

All cells with DNA – cancer, tissue, immune, blood cells, etc. secrete exosomes.

Mesenchymal stem cells (MSCs) release them too. Despite no reported side-by-side in-human studies, this mechanism has led some researchers and amateur stemcellologists to believe they are more effective than MSCs or ADRCs.

And where a therapeutic dose of MSCs might be 40 -100 million cells, exosome manufacturers claim their vials contain hundreds of millions. A South Florida “stem cell physician” touts one billion exosome vials – without evidence that more is better, much less sterile or safe.

Lab techs must multiply the MSCs or exosomes in culture to obtain a relevant dose.  However, maintaining current Good Manufacturing Practices (cGMP) requires adherence to rigorous standards.

Whodunnit?

Wondery’s ten-episode whodunnit, Bad Batch, illustrates the significant safety risks Liveyon’s slick marketing and non-sterile lab practices delivered to patients. In sum, over 200 patients reported severe adverse events.

Additionally, the CDC published its lab findings in the Journal of the American Medical Association (JAMA) in 2021.

Key Points
Question Were infections in patients who received umbilical cord blood products marketed as stem cell treatment associated with product contamination?

Findings In this case series, 20 patients in 8 states, developed bacterial infections after receiving unapproved products marketed as treatment for conditions including chronic pain and degenerative joint conditions. This national investigation found widespread bacterial contamination of undistributed and distributed products from multiple donors, with whole-genome sequencing indicating a common source.

Meaning The findings from this outbreak underscore that unapproved and unproven stem cell products can expose patients to serious risks without clear benefit, including the possibility of product contamination.

Of unopened, undistributed products sampled for testing, at least 1 of 16 bacterial species contaminated 65% (22 of 34 vials). [7]

Liveyon reincarnations
Yet the warnings failed to stem the umbilical cord stem cell (UBSC) tide nor remove dirty cells:

From an angle not addressed by the FDA, a global review of scientific literature across forty studies revealed that “forever chemicals” from toxic plastics were present in 30,000 umbilical cord blood samples.

Further, citing patient reports of adverse events from a Nebraska exosome clinic, the FDA issued a safety warning to the public.

What the hell is reactive arthritis after a “stem cell” injection?
Promoters of perinatal “stem cell” products claim there is no risk of immune rejection. In other words, they say umbilical cord Wharton’s Jelly does not require human leucocyte antigen (HLA) matching to pair patients and donors, as is done for blood or marrow transplants.

However, a mismatched case report contradicts their false claim.
“A 36-year-old man was injected with Wharton’s jelly for low back pain and within 24 hours developed fevers, chills, polyarthritis, and enthesitis. (Enthesitis is inflammation of the ‘enthesis”, which is where a tendon or ligament attaches to a bone.) Infectious disease work-up was negative. Inflammatory markers were elevated and his HLA-B27 antigen was positive. Initial treatment included methylprednisolone and sulfasalazine. This case highlights the unknown dangers of these allogenic injections and physicians should remain cautious about their use until further study and regulation can ensure patient safety.”[8]

An open penitentiary?
If these products are not FDA-approved and the labs do not comply with cGMP, how do companies get away with selling them? The manufacturers claim their products are for research purposes or ignore FDA regulations because they could care less.

  • Invitrix and Vitti Labs use disclaimers to stay one step ahead of the law.
  • Organicell hides behind the veil of several planned or ongoing phase 1 clinical trials.

Everybody speeds
A doctor wanting to participate in the stem cell wild, wild west asked a lawyer specializing in stem cell regulatory affairs:

Doctor: If I need regulatory approval to treat patients with stem cells, how come so many doctors do it anyway?
Lawyer: “Do you speed?”
Doctor: “All the time.”
Lawyer: “Is it illegal?”
Doctor: “I don’t care.”

Stories like Jury Convicts State Lawmaker of COVID-19 Fraud Scheme at Springfield Health Care Charity and Man falsely claiming to use “Stem Cell Therapy” convicted and sentenced to 202 years don’t seem to make a difference.

Stem Cells and exosomes for the healthy, wealthy
NextHealth at the Four Seasons Maui Resort mixes up the mania, offering Vitti Labs’ potentially contaminated umbilical cord “stem cells” and Organicell’s unapproved exosomes in their spa. They offer Stem Cells + Exosomes + Longevity IV Therapy for $16,000, a savings of $2,299.

Contrary to the FDA’s warning letters, a NextHealth patient coordinator insisted that Vitti’s and Organicell’s products are FDA-approved and that the manufacturers certify all lots are contaminant-free. Where did she get that idea?

From another angle, just because something is illegal doesn’t mean clever marketers partnering with iconic brands like the Four Seasons have consulted a lawyer specializing in FDA compliance. Or have read the literature cited herein.

Stem Cell Distributor expands dental practices
At the other end of the spectrum, New Life, an Invitrix and Organicell distributor, “works closely with clinicians and practitioners to enhance their care offerings…and expand their practices with “natural biologics (emphasis added).” But their research products page and disclaimer tell their customers – dentists, chiropractors, nurses, and doctors – their products are not FDA-approved.

Do Stem Cells Work?
“Of course, they work. We are all walking stem cell products – the sperm, and the egg.” James Willerson, MD, Ph.D. Dr. Willerson went on to publish Buying New Soul (2012). Here he hypothesized that adipose tissue was the best source of adult stem cells.

A growing body of literature supports Willerson’s supposition: A PubMed Central Search returned more than 100,000 publications that discuss adipose-derived stem cells. And over 35 published in-human Celution System studies validate the safety and effectiveness of clinical-grade ADRCs.

In contrast, experimenting on patients in dental offices or at ritzy hotels with potentially contaminated “natural biologics” that contain dead stem cells is a risky pod for patients to swallow.

[1] Perin EC. In Memoriam: James T. Willerson, MD (1939-2020). Tex Heart Inst J. 2020 Aug 1;47(4):242-243.

[2] Fortier LA, Cercone M, Keller LE, Delco ML, Becktell L, Wells KV. Amnion and Umbilical Cord–Derived Products in Sports Medicine: From Basic Science to Clinical Application. The American Journal of Sports Medicine. 2021;49(7):1954-1961

[3]https://legislature.vermont.gov/Documents/2020/WorkGroups/Senate%20Health%20and%20Welfare/Bills/S.252/Written%20Testimony/S.252~Jonathan%20Fenton~Consensus%20Statement%20on%20Aggressive%20Marketing%20of%20Birth%20Tissues%20as%20Stem%20Cell%20Therapies~2-28-2020.pdf

[4] Berger DR, Centeno CJ, Kisiday JD, McIlwraith CW, Steinmetz NJ. Colony Forming Potential and Protein Composition of Commercial Umbilical Cord Allograft Products in Comparison with Autologous Orthobiologics. Am J Sports Med. 2021 Oct;49(12):3404-3413.

[5] Panero AJ, Hirahara AM, Andersen WJ, Rothenberg J, Fierro F. Are Amniotic Fluid Products Stem Cell Therapies? A Study of Amniotic Fluid Preparations for Mesenchymal Stem Cells With Bone Marrow Comparison. The American Journal of Sports Medicine. 2019;47(5):1230-1235.

[6] Turner L The American stem cell sell in 2021: U.S. businesses selling unlicensed and unproven stem cell interventions Cell Stem Cell 28, November 4, 2021

[7] Hartnett KP, Powell KM, Rankin D, et al. Investigation of Bacterial Infections Among Patients Treated with Umbilical Cord Blood–Derived Products Marketed as Stem Cell Therapies. JAMA Netw Open.2021;4(10): e2128615.

[8] Madhoun et al. Induction of HLA-B27–Associated Reactive Arthritis After a Wharton’s Jelly “Stem Cell” Injection Am J Phys Med Rehabil 2020;99:e142–e145

AMBROSE Cell Therapy

Your Right to Try

A Golden Era of Cell-Assisted Memory and Vascular Health

A Golden Era of Cell-Assisted Memory and Vascular Health

A Golden Era of Cell-Assisted Memory and Vascular Health

Sam’s Patient Reported Outcome

Sam was a productive dentist, recreational golfer, proud parent, and happy husband. However, in 2013 his wife Flo, a retired physician, began a bold twenty-year battle to reverse his dementia, vascular disease, and pre-diabetes. In April 2020, Sam suffered a stroke and contracted Covid and pneumonia in the hospital. He remained there for two months.

In March 2022, Sam and his wife, Flo, exercised Sam’s Right-to-Try AMBROSE Cell Therapy. Seven months later, he stated, “I am a new man. I have much more energy. My thinking is clearer. I was worried about myself at one time, but not anymore.”

We will return to Sam’s story in a moment; first, some background on the power of blood flow and the risks of ischemia (lack of blood flow).

Sam’s Lifeblood –
Ancient Eastern societies (Phoenicians, Persians, Egyptians, and Hebrews) attached beliefs about blood to the origins of religion. Some Greek savants considered blood the same as the soul or spirit.

Further, the Greeks developed the first scientific considerations about blood. Back in Homer’s time (8th or 9th Century BC), they summarized four concepts that remain valid to day:

a) Blood is essential for life
b) Death is considered final when a lack of blood causes it
c) Clashes in which murder and blood make their appearance are horrible
d) Tribes, nations, and families regard blood as a bond

Finally, the Greeks believed good and virtuous blood characterized a courageous, valiant, and principled person.[1]

Following the Ancients’ theme, Merriam-Webster defines lifeblood as “the seat of vitality.” 

Ischemia – Sam’s life suck
In 1885, Rudolph Virchow coined “ischemia” to characterize the lack of blood flow in an organ or tissue. In plain words, ischemia means blood is not moving through your capillaries, blood vessels, veins, or arteries.

The Po River nourishes Northern Italy’s expansive farms. But 2022’s global heat wave starved Italy’s breadbasket of vital nutrients and harmed the economy,

Similarly, Sam’s blood flow feeds his cells, tissues, and organs, but inflammation-induced ischemia sucked the vitality from Sam’s life.

Sam’s long decline

  • Ten years of smoking
  • Decades-long mercury exposure from practicing dentistry; he retired in 2008
  • He ate the standard American diet (SAD) plus over-indulged in mercury-laden sushi.
  • In 2002, he had surgeries for a torn rotator cuff and a fractured left wrist.
  • In 2013, a noticeable cognitive decline set in. His Montreal Cognitive Assessment or the MoCA Test— had diminished to 16 out of 30, or about half of normal. MoCA is the most sensitive test available for measuring dementia.[2]
  • In 2016, Sam’s doctors diagnosed him with vascular dementia and pre-diabetes.
  • Somewhere along the line, he developed chronic lower back pain.
  • In 2020, he suffered an ischemic stroke and contracted Covid and pneumonia in the hospital, where he remained for an additional two months.

In short, Sam’s diffuse (widespread) vascular, metabolic, and musculoskeletal disease foretold of dementia and the stroke yet to come.[3] [4]

Sam’s history epitomizes the complexity of age-related ill health:

  • Many of the factors associated with heart disease – for instance, high blood pressure, high cholesterol, and smoking are evident in patients with dementia and Alzheimer’s Disease (AD).
  • A common cause of dementia is cerebrovascular disease or damage to the blood vessels in the brain.
  • Elevated mercury levels are a less well-discussed culprit of heart disease and neurodegenerative conditions.
  • The risk of vascular dementia increases with a stroke.

Flo’s Relentless Quest
In 2016, Flo found Dr. Dale Bredesen and the RECODE protocol. For several years Sam responded to RECODE. His MoCA score improved from 16 to 19.

Unfortunately, Sam’s vascular disease caught up with him in early 2020. He had a stroke and contracted Covid and pneumonia in the hospital, requiring a two-month stay. Research has since revealed that the Corona-19 virus attacks the endothelium (inner lining of the blood vessels), adding more risk to Sam’s future. [5]

In 2021, Flo, a retired physician, became concerned that her husband had plateaued. After researching stem cell therapy options, she recommended Ambrose Cell Therapy to Sam in 2022.

Sam’s Disease Progression
Sam’s first sign of ischemia was elevated blood pressure or hypertension (HTN). “His BP became a problem at least ten years ago.”, recalled Flo.

Cardiologists refer to HTN as the silent killer because it leads to heart attacks and strokes.

From 2009 to 2019, the deaths attributable to high BP rose by two-thirds, an astonishing number considering that one in four adults take antihypertensive medications.[6] [7]

  • Every cigarette Sam or anyone smokes causes a temporary rise in blood pressure. And smoking leads to hardening and narrowing of the arteries (atherosclerosis). Thus, a smoker’s blood is more likely to clot, forcing the heart to work harder.
  • Mercury toxicity correlates with hypertension, coronary heart disease, cerebrovascular incidents, and atherosclerosis.
  • Insulin resistance, i.e., pre-diabetes, is associated with low cerebral blood flow (perfusion).
  • Pre-diabetes, a hallmark of metabolic syndrome, links to vascular dementia. [8] [9] [10] [11] [12]

Flo’s Distrust
Flo, a retired physician, lacked confidence in the standard-of-care drugs, e.g., Donepezil (Aricept) and Memantine (Namenda). “I didn’t let the doctors put Sam on those medications. I saw they had short-term benefits but could make things worse with long-term use.”

A British study published in 2004 suggested that Aricept has “disappointingly little overall benefit and is not worth the cost.”

Flo also knew to steer clear of drug combinations, including anti-depressants, anti-psychotics, anti-seizure, and sleep meds (polypharmacy). Neurologists prescribe polypharmacy to patients with neurodegenerative diseases despite its well-documented contribution to the progression and severity of dementia. In other words, drug companies profit, and patients pay the price. [13] [14] [15] [16]

In May 2022, Sam presented to Ambrose with:

  • Vascular dementia
  • Post-stroke left-side imbalance and difficulty swallowing
  • Elevated blood pressure, controlled with medication (Losartan)
  • High cholesterol
  • Pre-diabetes HbA1C 6.3, fasting glucose 106.
  • High inflammatory markers, including homocysteine – 8.4
  • Chronic lower back pain
  • Shoulder arthritis
  • Reclusive and depressed

Harnessing Sam’s Innate Biology
Flo believed in the body’s power to heal itself. That is why she was attracted to the RECODE protocol.

After Sam’s improvement stalled, she took the logical next step of researching stem cell therapy. But Google search results ranked common misinformation high. “Aren’t umbilical cord stem cells (UBSCs) more potent and effective than fat stem cells?” she asked.

Our critical review of Tony Robbin’s Life Force sets the record straight: Researchers have established that ADRCs are the most accessible, abundant, and potent cell population. Contrary to the extant dogma, stem cell depletion does not apply to ADRCs.[17]

Dozens of peer-reviewed studies supported the potential to treat Sam’s combined disabilities in a single outpatient procedure.

Making an informed choice
Flo requested papers supporting potential benefits for Sam’s memory.

  • In 2017 the University of Louisville’s Cardiovascular Innovation Institute demonstrated that intravenous delivery of ADRCs could improve blood vessel health. They predicted “the intravenous delivery of this therapeutic cell population would significantly improve tissue perfusion (the passage of blood), particularly in diseases with diffuse (widely spread) vascular involvement.”[18]
  • A just-published Japanese poster presentation reported remarkable improvements in MOCA scores after IV infusion of adipose-derived–mesenchymal stem cells (ADSCs or Ad-MSC).[19]
  • Another study out of Japan demonstrated, “Treatment with Ad-MSC significantly improved HDL, LDL, and remnant-like particle (RLP) cholesterol levels…These findings suggest that Ad-MSC administration is safe and effective in patients developing arteriosclerosis, thereby providing an attractive tool for anti-aging application.[20]
  • Japanese researchers from Nagoya University concluded in a 2022 review article, Adipose-derived regenerative cells as a promising therapy for cardiovascular diseases: an overview, “Therapeutic angiogenesis (new blood vessel growth) has been developed as a new treatment strategy for such patients.” [21]

 Ischemia – the Tip of the Iceberg
A robust body of literature confirms that ischemia is just the tip of the dementia iceberg. As we have discussed in articles on cell-assisted brain care, aging, and long-Covid recovery, chronic disease involves multisystem dysregulation.

A Golden Era of Self-Cell Repair details the research and discovery path upon which we base Ambrose Cell Therapy’s safety and potential effectiveness.  [22]

Sam’s Personalized Protocol
Per the Ambrose Master Protocol:

  1. Ambrose’s board-certified plastic surgeon harvested 370 ccs of adipose tissue. The Celution™ System processed 310 ccs yielding 68 million ADRCs with 92% viability.
  1. Ambrose’s fellowship-trained interventional pain specialist utilized the remaining 60 ccs to deliver 44 injections of PRP-enriched micro-fat:
  • Para-spinal and para-facet injections -24
  • Right shoulder -13
  • Left wrist – 7

Summary of Benefits
Per Flo, over ten months, Sam went from reclusive, demented, and in chronic back pain to socializing with friends, playing an occasional round of golf, and enjoying his grandchildren.

He helps Flo with chores and preparing dinner and takes the initiative to attend church, meditate, and exercise. He engages in conversation without repeating himself. Flo wants to see his short-term memory improve but acknowledges Sam’s significant quality of life improvement.

Consistent with the studies Ambrose provided to Flo, objective evidence indicates cell therapy lowered Sam’s risk of another catastrophic stroke or a heart attack.

  • His blood pressure normalized -120/80 or better most days – allowing him to discontinue losartan in the first few weeks following Sam’s Ambrose.
  • His metabolic health and systemic inflammation showed remarkable improvement.
    • HbA1C – 6.4 to 5.3
    • Fasting glucose – 106 to 99
    • Homocysteine – 8.4 to 6.0

Sam’s cholesterol remained high until Flo put him on Zetia and a low dose of Crestor. The keto diet raises cholesterol in some and lowers it in others.

Setbacks
To be clear, Sam has had a few setbacks, including a bout of severe constipation. Diet changes resolved that issue.

He also had a flare of debilitating back pain. Notably, his current MRI shows multi-level spinal degeneration and facet arthritis. However, his months of better function, including long walks and restarting golf, lend credence to the Ambrose Cell-Assisted Spine Care Hypothesis.

With rest and conservative physical therapy, Sam said, “My back is better.” He resumed his daily walks a few weeks later.

Sam’s Perspective
“Stem cells are the future. I am a new man. I have much more energy. I am thinking much more clearly. I was worried about myself at one time, but not anymore.”

“It’s going well. I am doing very much better. I am playing golf. We are visiting our son and grandchildren in Hamptons this weekend,” declared Sam.

He had quit golf four years ago and had not visited his family in several years.

Details – Sam’s improving quality of life timeline (edited for brevity and clarity):

  • April: Not repeating questions as often, short-term memory starting to improve. Sam’s masseuse noted he didn’t repeat the same question. And Sam asked about her daughter for the first time. He initiated going to exercise, church, and meditating.
  • His blood pressure normalized. He discontinued losartan.
  • May – Sam surprised Flo with Mother’s Day Flowers and teased her that her boyfriend from high school must have sent them.
  • June – He played golf after quitting four years ago. Flo: “Good news Matt, we played golf – 9 holes, he had fun even though he didn’t play well, but he was able to give me some instructions and vice versa. Beautiful day today. He was fine and willing to go when I brought it up. I was so happy.”
  • Left side imbalance from stroke is no longer evident. “He keeps his balance when walking. Swallowing is better.”, said Flo.
  • Their son, Fred, a prominent healthcare mutual fund manager, acknowledged, “Dad is getting better.”, which is also a first.
  • Sam and Flo had dinner with friends in New York City: “We had a good time. Sam had a good conversation with the others. However, he was not in a good mood. It looks like he got out of the wrong side of the bed. Sam did have these kinds of moments a lot, but recently it is unusual.”
  • July – “I have good news this morning. My brother called Sam for his birthday. He did really good. Usually, he talks a little and hands me the phone, but this time they had a long conversation with laughs and jokes. I haven’t seen this for a long, long time. I think it is really positive progress.”
  • August – Sam spoke for himself rather than deferring to Flo on a one-hour follow-up call. “I am a new man. I have much more energy, much more clear thinking. At one time, I was worried about myself, but not anymore,” he stated.
  • Sam and Flo drove to the Hamptons to see their son and children. Their daughter’s family joined them. “Today, Sun played golf with our son, Fred, and our son-in-law, Jim. He had a good round. This trip was the first time Sam packed his things by himself. He didn’t have much anxiety like before…definitely improved. Jim said, ‘Dad is doing better for sure. Whatever I’m doing is helping him. When he played golf, his back was fine.”, Flo shared after the gathering.
  • “We spent all afternoon (at the US Open) watching Medvedev and Coco play in Ashe Stadium. It was fun to be there and feel the action. Overall, we had fun watching the tennis and excitement.”
  • September – Back to East Hampton for their grandson’s birthday. “Our son was surprised we stayed that long. Sam had fun and mingled with the guests. He didn’t have any issues.”
  • October – Flo reports, “I have some good news. We went to speech therapy. Sometimes I don’t hear him well. The therapist asked him lots of questions. She did not want me to answer for Sam. I was delighted to see his improvement.”
  • December 9 – Last night, Sam had a good conversation with his longtime friend in LA. They chatted with each other, including me. Sam was engaged in the conversation. It made me happy. At first, he didn’t remember it the next day, but after a little hint, he got it and remembered.”
  • From Flo: “Sam’s phone has Face ID. I tried to help him log into Fidelity; of course, it didn’t recognize his face. He said, ‘how could you not recognize my wife’s face? Everything in there is hers!’”

As 2022 came to an end, Flo said, “Matt, I’d like to thank you for your support all year long. It’s been a great year for us.”

[1] John Meletis and Kostas Konstantopoulos The Beliefs, Myths, and Reality Surrounding
the Word Hema (Blood) from Homer to the Present Anemia Volume 2010, Article ID 857657

[2] https://www.mocatest.org/about/

[3] Birdsill AC, Carlsson CM, Willette AA, et al. Low cerebral blood flow is associated with lower memory function in metabolic syndrome. Obesity 2013; 21: 1313–1320

[4] Hoscheidt et al.  Insulin resistance is associated with lower arterial blood flow and reduced cortical perfusion in cognitively asymptomatic middle-aged adults Journal of Cerebral Blood Flow & Metabolism 37(6)

[5] Levy et al. Endothelial Injury in COVID-19 and Acute Infections Arterioscler Thromb Vasc Biol. 2021;41:1774–1776

[6] Tsao C et al.  Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association Circulation Vol 145 Issue 8 February 2022

[7] Satoh M et al. Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level Hypertension AHA Volume 73, Issue 1, January 2019; Pages 52-59

[8] Patwa J, Flora SJS. Heavy Metal-Induced Cerebral Small Vessel Disease: Insights into Molecular Mechanisms and Possible Reversal Strategies. International Journal of Molecular Sciences. 2020; 21(11):3862.

[9] Siblerud, Robert et al. “A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer’s Disease.” International journal of environmental research and public health vol. 16,24 5152. 17 Dec. 2019,

[10] Genchi, Giuseppe et al. “Mercury Exposure and Heart Diseases.” International journal of environmental research and public health vol. 14,1 74. 12 Jan. 2017

[11] Houston, M.C. (2011), Role of Mercury Toxicity in Hypertension, Cardiovascular Disease, and Stroke. The Journal of Clinical Hypertension, 13: 621-627.

[12] Garfield et al.  HbA1c and brain health across the entire glycaemic spectrum. Diabetes Obes Metab.  2021; 23: 1140– 1149.

[13] Cummings, J, Lee, G, Nahed, P, et al.  Alzheimer’s disease drug development pipeline: 2022. Alzheimer’s Dement.  2022; 8:e12295

[14] Cummings, JL, Goldman, DP, Simmons-Stern, NR, Ponton, E.  The costs of developing treatments for Alzheimer’s disease: A retrospective exploration. Alzheimer’s Dement.  2022; 18: 469– 477.

[15] The scale and profile of global dementia research funding https://alzimpact.org/research

[16] Park, Hae-Young et al. “The Association between Polypharmacy and Dementia: A Nested Case-Control Study Based on a 12-Year Longitudinal Cohort Database in South Korea.” PloS one vol. 12,1 e0169463. 5 Jan. 2017

[17] Willerson J and Perin E Buying New Soul J Am Coll Cardiol. 2012;60(21):2250-2251

[18] Morris ME et al. Systemically Delivered Adipose Stromal Vascular Fraction Cells Disseminate to Peripheral Artery Walls and Reduce Vasomotor Tone Through a CD11b+Cell-Dependent Mechanism STEM CELLS TRANSLATIONAL MEDICINE 2015;4:369–380

[19] Shigematsu, Kazuo, et al. “Repeated intravenous infusion of autologous adipose‐derived stem cells improves cognitive function.” Alzheimer’s & Dementia 17 (2021): e049907.

[20] Ohta et al. Autologous adipose mesenchymal stem cell administration in arteriosclerosis and potential for anti-aging application: a retrospective cohort study Stem Cell Research & Therapy (2020) 11:538

[21] Nagoya J et al Adipose-derived regenerative cells as a promising therapy for cardiovascular diseases: an overview Med. Sci. 84. 208–215, 2022

[22] Hirose, Yujiro et al. Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals Cytotherapy, Volume 20, Issue 4, 589 – 591

AMBROSE Cell Therapy

Your Right to Try

A Golden Era of Cell-Assisted Resilience

A Golden Era of Cell-Assisted Resilience

A Golden Era of Cell-Assisted Resilience

RJ’s Patient-Reported Outcome

Sports-related injuries, including concussions and whiplash, three failed shoulder surgeries, an unsuccessful right knee surgery, etc., retired RJ’s dream of playing Major League Baseball.

In May 2022, he exercised his Right to Try AMBROSE Cell Therapy. Seven months later, he says, “Y’all (AMBROSE) changed my life.”

RJ’s Story
RJ played baseball, football, snowboarding, and golf growing up.

“I had some concussions and whiplash from football and a few car accidents along the way.”

RJ’s shoulder issues started in high school. Initially, his doctor thought it was bicep tendonitis. “I had to take a month off every year. It never felt good.”

One issue led to another. “When I was 17, I blew out my left knee running second base. After that, it would give out a lot.” The MRI showed his femur had lengthened, but it had never bothered RJ before the spill.

RJ’s orthopedic surgeon shaved the femur down and cleaned up the knee. “After the surgery, I did P.T. My knee felt better. I could run but couldn’t walk downhill or stairs.”

Jumping ahead, before his AMBROSE Cell Therapy, RJ complained of left knee pain, clicking, and inability to walk downstairs or a hill. His right knee was symptomatic from compensating. “I could run, but it hurt,” he later said.

Resuming RJ’s story: “I went back to playing baseball. My shoulder gave out after the first couple of days.”

“Nothing showed up on my MRI and X-Ray, but I couldn’t move my arm. I went in for exploratory surgery. The surgeon found my rotator cuff and labrum were shredded.

He repaired it, but then every season, it would give out”, RJ recounted.

Doctors refer to the shoulder joint’s major tendons as the rotator cuff. Rotator cuff tears are common injuries. Advances in surgery have improved rotator cuff repairs. But failure rates remain high.

Here, RJ’s massive rotator cuff tear (MRCT) caused disability and pain. An MRCT precipitates a Spiral of Degeneration beginning with inflammation, abnormal immune response, and lack of blood flow. That leads to programmed cell death (apoptosis), scarring, and degeneration.

Unknown to many people and a key reason shoulder surgeries have such a high failure rate, the muscle around the rotator cuff shrinks, and the body replaces it with fatty tissue.

When the tendon and muscle are finally reattached surgically to the shoulder bone, the weakened muscle can’t handle everyday stresses, and the area can be re-injured.

“I tore my rotator cuff and labrum twice more, each followed by another surgery. Both surgeries failed. In between, I ripped a hamstring, broke some fingers, and fractured my hand while stealing second base,” he said.

Cortisone injections, PRP, and physical therapy failed to bring lasting relief.

In his senior year in college and after the last surgery, his baseball coach discouraged RJ from returning to the team.

Allostatic Load and Anti-resilience.
Sterling and Eyer introduced the concept of allostasis in 1988 as stability through change. From the Greek állos, “other,” “different” + stasis, “standing still.” The researchers were imparting the concept of “remaining stable by being variable.”.

Just as a sailor keeps his boat on an even keel despite choppy waters, the body’s biological systems maintain their equilibrium (homeostasis), despite being put through stress.

In contrast, allostatic Load is “the wear and tear on the body” accumulated from repeated or chronic stress. (Bruce McEwen and Eliot Stellar 1993) Sailing across tall breaking waves over and over can cause irreparable damage.

After RJ’s sports injuries, concussions, surgeries, and competitive stress, his physiologic systems were striking out. He descended from an elite baseball player to being told by his college coach that the disabled list was not a viable option.

By age 23, RJ experienced debilitating symptoms beyond losing his ability to throw with his right arm and run the bases. He stopped bouncing back. In other words, allostatic load set in.

Baseline
RJ’s constellation of wear and tear complaints included:

  • Right shoulder pain, decreased mobility, and left shoulder stiffness.
  • Right elbow stiff, made clicking noises, left elbow stiffness though no pain, no clicking
  • Bilateral arms, decreased reflexes with hammer exam
  • Right knee, sharp pain with walking, early knee fatigue with running, aches in cold weather.
  • Left knee clicking, popping, and stiffness from compensating
  • Challenging to walk downstairs or declines.
  • Lower neck – intermittent numbness and radiation of numbness and tingling into the arm
  • Right upper arm, numbness near upper biceps insertion, constant
  • Right upper arm to fingers (middle & ring fingers), tingling, intermittent nerve pain

More concerning, RJ experienced symptoms of multisystem dysregulation:

  • Vertigo, when looking rapidly with turning his head
  • Daily headaches
  • Sleeping 15 hours per day,
  • Waking up drenched from night sweats
  • Depression
  • An extreme tendency to fall asleep (narcolepsy)
  • Chronic fatigue

In short, allostatic load was ahead 3-2 with the bases loaded in the bottom of the 9th inning. The odds were stacked against RJ Surgeries and drugs had failed him. Though recommended, RJ had the good sense of avoiding pain meds and psychotropic drugs such as Prozac, which could have worsened matters.

Fortunately, RJ had the Right to Try AMBROSE Cell Therapy.

ADRC-assisted Resilience
Based on abundant literature, AMBROSE hypothesized that ADRC-based therapy could unburden allostatic load.[1] [2] [3]  [4] [5] [6] [7]  [8] [9] [10] [11]

Further, preeminent researchers from the Texas Heart Institute, University of Tokyo, Cedar-Sinai, and other respected institutions have published studies that support ADRCs’ potential to treat multiple chronic conditions. [12] [13] [14] [15] [16]

The medical team personalized the AMBROSE Master Protocol to address RJ’s unique health challenges.

  1. Fat Harvesting
    Using minimally traumatic water-assisted liposuction technology (WAL), AMBROSE’s board-certified plastic surgeon harvested 580 ccs (19 oz) of adipose tissue. Post-procedure, RJ reported using only Tylenol for a few days.
  1. Spine and Joint Injections
    AMBROSE relied on published research in addressing the patient’s cervical spine and diseased joints with PRP-enriched micronized fat injections. [17] [18] [19] [20] [21] [22] [23]

AMBROSE’s fellowship-trained interventional pain specialist delivered 61 precise injections under real-time ultrasound guidance into RJs:

  • Inflamed cervical spine (22 injections)
  • Arthritic shoulders and bicep tendons (8 injections),
  • Sore elbows (3 injections)
  • Painful, clicking knees (18 injections).

Results
Seven months out, RJ is playing golf, swinging the baseball bat again, running, walking down declines, lifting weights, and coaching high school football and baseball.

As a result of compensating for his bum shoulder, his right elbow became his biggest problem. “My arm feels really good now- no pain, clicking, or stiffness.” He is throwing the baseball again, though, taking his time to rebuild his deconditioned shoulder muscle.

After his knee surgery, his knees deteriorated. He says, “Running is no problem now; The sharp pain and stiffness are gone. I can walk downstairs and hills again. My friends don’t laugh at me anymore.”

“My neck is much better. I don’t have the numbness and tingling. I don’t get dizzy when I turn it to the side. I haven’t recovered full range of motion yet – but that is getting better too.”, RJ added

  1. ADRC-IV Infusion
    RJ received 129 million Celution™ system processed ADRCs with 92% cell viability through IV infusion.

Published research has established that the ADRC-IV infusion reduces neuroinflammation, improves blood flow, restores autonomic nervous system function, and so on. RJ’s real-world results validate the cited studies. [24] [25] [26]

As an aside, our group’s research revealed the Celution system significantly outperforms the Medikhan, Tissue Genesis Icellator, and other commercially available adipose cell processing systems.[27] [28]

IV Results
In line with the cited publications (and others), RJ started feeling better not long after his AMBROSE treatment.

“I don’t feel depressed like I did before. I am optimistic and have more energy. I don’t wake up drenched with sweat and only need about eight hours of sleep now. I used to sleep from 12:00 am to 2:00 pm and take an hour nap too. Now I coach baseball and football 15 hours a day.”, RJ reported.

He went back to the gym, resumed light weightlifting, and lost 15 lbs. – with no change in diet. RJ added, “I haven’t been in this good of shape for at least two years,”

RJ’s benefits signal a reduction in allostatic load and restoration of multisystem homeostasis.

 

RJ is not alone.
Research studies have established a direct link between increasing allostatic Load and all-cause mortality. Unsurprisingly, studies have also connected heart disease, diabetes, kidney disease, lung disease, and so on with allostatic Load. Thus, beyond RJ’s poor health, he was at high risk of getting worse at a young age. [29]

Today’s environmental, psychological, and lifestyle factors are accelerating the time-to-allostatic Load:

Conclusion
 “The doctors and surgery center team were the best I have had. My future has gone from bleak to bright. I appreciate Matt Feshbach, AMBROSE CEO, for his follow-up and friendship. For me, AMBROSE was a grand slam.”, RJ concluded.

[1] Ghachem, A., Fried, L.P., Legault, V. et al. Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems. Biogerontology 22, 63–79 (2021).

[2] Gross, Alden L et al. “Derivation of a measure of physiological multisystem dysregulation: Results from WHAS and health ABC.” Mechanisms of ageing and development vol. 188 (2020): 111258.

[3] Guidi J, Lucente M, Sonino N, Fava G, A: Allostatic Load and Its Impact on Health: A Systematic Review. Psychother Psychosom 2021;90:11-27.

[4] Hirose Y et al. Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals Cytotherapy, 2018; 20: 589–591

[5] VL Negenborn et al. Autologous Fat Grafting as a Last Resort for Unsustainable Pain in a Woman with Multiple Osteochondromas Archives of Plastic Surgery Vol. 44 No. 2 March 2017

[6] S Tamburino et al The Role of Nanofat Grafting in Vulvar Lichen Sclerosus: A Preliminary Report Arch Plast Surg 2016;43:93-95

[7] H Riyat et al Autologous fat grafting for scars, healing and pain: a review Scars, Burns & Healing Volume 3: 1–

[8] T Lopatina et al. (2011) Adipose-Derived Stem Cells Stimulate Regeneration of Peripheral Nerves: BDNF Secreted by These Cells Promotes Nerve Healing and Axon Growth De Novo. PLoS ONE 6(3): e178991

[9] S.  Seigo et al, Uncultured adipose-derived regenerative cells promote peripheral nerve regeneration, Journal of Orthopaedic Science, Volume 18, Issue 1,2013, Pages 145-151

[10] Blaszkiewicz, M., Wood, E., Koizar, S. et al. The involvement of neuroimmune cells in adipose innervation. Mol Med 26, 126 (2020)

[11] F Caviggioli, M.D. Autologous Fat Graft in Postmastectomy Pain Syndrome Plastic and Reconstructive Surgery August 2011

[12] S. Kesten and JK Fraser Autologous Adipose Derived Regenerative Cells: A Platform for Therapeutic Applications Advanced Wound Healing Surgical Technology International XXIX

[13] Nguyen A et al. Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 170e179

[14] Guo J et al. Stromal vascular fraction: A regenerative reality? Part 2: Mechanisms of regenerative action Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 180e188

[15] Al-Ghadban S, Artiles M, Bunnell BA. Adipose Stem Cells in Regenerative Medicine: Looking Forward. Front Bioeng Biotechnol. 2022; 9:837464. Published 2022 Jan 13.

[16] J. Willerson and E. Perin Buying New Soul J Am Coll Cardiol. 2012;60(21):2250-2251

[17] Ibrahim, Samir, Rybacka-Mossakowska, Joanna and Michalak, Sławomir. “Fat graft – the natural choice for reconstructive, regenerative and aesthetic surgery” Medical Journal of Cell Biology, vol.5, no.2, 2017, pp.113-117. https://doi.org/10.1515/acb-2017-0008

[18] Heather Vinet-Jones*,1 & Kevin F Darr Clinical use of autologous micro-fragmented fat progressively restores pain and function in shoulder osteoarthritis Regen.Med. (2020) 15(10), 2153–2161

[19] Striano Rd, Malanga G, Bilbool N, Azatullah K. Refractory shoulder pain with osteoarthritis, and rotator cuff tear, treated with micro-fragmented adipose tissue. J. Orthopaedics Spine Sports Med. 2(1), 14–19 (2018).

[20] Lädermann A, Denard PJ, Burkhart SS. Management of failed rotator cuff repair: a systematic review. J ISAKOS. 2016;1(1):32-37. doi:10.1136/jisakos-2015-000027

[21] Heather Vinet-Jones & Kevin F Darr Clinical use of autologous micro-fragmented fat progressively restores pain and function in shoulder osteoarthritis Future Medicine Ltd Regenerative Medicine Volume 15, Issue 10, October 2020, Pages 2153-2161

[22] D.M. Robinson, C. Eng, M. Mitchkash, A.S. Tenforde, J. Borg-Stein Outcomes after Micronized Fat Adipose Transfer for Glenohumeral Joint Arthritis and Rotator Cuff Pathology: a Case Series of 18 Shoulders Muscles, Ligaments and Tendons Journal 2020;10 (3)

[23] Itro, A. et al. Why Use Adipose-Derived Mesenchymal Stem Cells in Tendinopathic Patients: A Systematic Review. Pharmaceutics 2022, 14, 1151.

[24] J Rosenstein, J Krum & C Ruhrberg VEGF in the nervous system Organogenesis 6:2, 107-114; April/May/June 2010; © 2010 Landes Bioscience

[25] Numan MT et al. Autologous Adipose Stem Cell Therapy for Autonomic Nervous System Dysfunction in Two Young Patients. Stem Cells and Development 2017 26:6, 391-393 

[26] J. Vaquero et al Progressive increase in brain glucose metabolism after intrathecal administration of autologous mesenchymal stromal cells in patients with diffuse axonal injury Cytotherapy, 2018; 20: 806–819

[27] A Caplan PhD Mesenchymal Stem Cells J Orthop Res, Vol. 9, No. 5, 1991

[28] Skok M. Mesenchymal stem cells as a potential therapeutic tool to cure cognitive impairment caused by neuroinflammation. World J Stem Cells 2021; 13(8): 1072-1083

[29] P.G. Shiels et al. Circulating markers of ageing and allostatic load: A slow train coming Practical Laboratory Medicine 7 (2017) 49–5451

AMBROSE Cell Therapy

Your Right to Try