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Realistic Expectations and Optimizing Your Outcome

Realistic Expectations and Optimizing Your Outcome

Realistic Expectations and Optimizing Your Outcome

It remains obvious that lifestyle contributes to health or disease. Excessive work, being sedentary, smoking, substance abuse, a poor diet, unhealthy relationships, etc., are associated with poor health.

Therefore, patients who take responsibility for their overall health and outcome are more likely to super-respond to their cell therapy.

On the opposite side of the coin, ignoring the basics of health and wellness should mute your expectations. Your outcome will be better to the degree that you contribute to the repair process.

FAQs

When should I begin exercise?
You may start walking and light exercise within a week or two of your procedure, depending upon when you feel up to it.

Patients should begin exercising at 25% of their normal level at about four weeks out. You may increase that by 25% every two weeks. In other words, most patients take a little more than two months to return to playing golf, tennis, yoga or working out.

You should take your time before resuming sports known to stress the musculoskeletal system. Your body will tell you if you are doing too much too soon or can do more than the formula above.

The repair process takes time. Exercise helps it but rushing back into sports works against that process. The needed period varies from person to person. Patience remains a virtue.

When will I begin to experience benefits?
Every patient is unique; therefore, their path of improvement differs. Bearing that in mind, most patients experience notable benefits between four and six weeks.
Because ADRCs are regenerative and restorative, they continue to do their jobs for months and even years. Many patients say their rate of benefit accelerated over time.

What to expect when?
No two patients have responded the same, yet AMBROSE’s Patient-Reported Outcomes suggest a pattern:

  1. Patients feel an emotional lift. They express this as more energy, happier, equanimity, a sense of well-being, and mental clarity.
  2. Pain begins to subside, and function starts to improve.
  3. They become more active.

Is stem cell therapy a cure?
A cure implies one never experiences a sign or symptom of a disease again. This expectation is unrealistic. In contrast, Ambrose Cell Therapy aims to improve symptoms, function, and quality of life.

Who benefits the most?
Patients who adopt or continue common sense diet, exercise, and lifestyle practices benefit the most from cell therapy.
Notably, Ambrose can eliminate the requirement for extreme diets, excessive supplements, regular chiropractic adjustments, and so forth.
From a different angle, people who failed to respond to PT or other conservative modes of therapy before AMBROSE often do so after their treatment. Published studies support this potential benefit.

What causes a flare?
Levels of physical or psychological stress exceeding what an individual can tolerate fight with the healing process.

For example:

  • Some exercises aggravate back pain, e.g., crunches, the treadmill, and some stretches. It is different for everybody.
  • The same holds for shoulders, hips, knees, and so forth. You may find eliminating a particular exercise, dialing back the frequency or intensity, or improving your form resolves the flare.
  • Inactivity and overdoing exercise cause relapses or lack of response in the first place.
  • Dementia, Parkinson’s, MS, and other neurologic conditions lower tolerance for psychological and physical stress. Travel, work, large gatherings, and negativity may be too much for individuals living with these diseases. Thus, patients and their caregivers should not expect to travel, work, and socialize as they did before the onset of their condition. As symptoms subside, the goal is to return to activities with family and friends, sports, and work as appropriate for them.
  • Sometimes caregivers over-care for the family member. They bring them to multiple healthcare providers, restrict their diets, overdo nutritional supplements, and so on. Despite one’s best intentions, this approach adds stress. Instead, the best therapies are being with family and friends and doing enjoyable, relaxing activities.

Improving Cell Therapy Outcomes explains the cycle of stress in more detail.

In summary, listen to your body and manage your activities accordingly. As the body becomes healthier, you can do more. On the other side of the coin, if specific exercises cause pain or other symptoms, it is essential to identify the triggers and modify what you are doing.

AMBROSE Cell Therapy

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Tony Robbin’s Life Force Stem Cell Discussion Review

Tony Robbin’s Life Force Stem Cell Discussion Review

Tony Robbin’s Life Force Stem Cell Discussion Review

“After so many years of agony from my spinal stenosis, now I was standing straight and strong without an ounce of pain in my back. It felt supple and free, better than it had in decades. You know that expression, I felt like a brand-new person? Without exaggeration, that new person was me. Six years later, my shoulder is still perfect, with full range of motion. I don’t baby it; to be honest[…]” Life Force Tony Robbins, Peter Diamandis MD, and Robert Hariri MD

Tony Robbins wrote Life Force so we could be the CEOs of our health. He brings stem cell therapy to the front of the stage with his “brand-new person” account of his stem cell treatment in Panama. He tells a larger-than-life story because, well, that is Tony.

As to the science, Tony relies on well-respected experts (with whom he invests) for his “facts.” However, his stem cell explanation suffers from what behavioral finance gurus call “cognitive bias” (A. Tversky and D. Kahneman 1972).

Why Our Review?
This review separates fact from bias and real-world outcomes from unrealistic expectations. Further, we reconstruct Tony’s inspiring yet ambiguous narrative into a clarifying before-during-and-after timeline.

We presume that Tony benefited from cell therapy. Stem cells are effective in treating the conditions from which he suffered. It is just hard to know how much, for how long, and why. In Chapter 18, Tony dropped a subtle bomb on his born-again in Panama story: He did another treatment to handle the “challenges” related to the Panama treatment discussed in Chapter 2. More on that in a moment, first this review’s purpose.

Realistic Expectations
Our review aims to set realistic expectations and empower patients to make an informed choice regarding stem cell therapy. As Warren Buffett once counseled a CEO, “The way to have a happy marriage is to marry someone with low expectations.” Better said, it is best to set expectations cell therapy can meet or beat. Claims of immediate miracle cures do not help anyone.

Unfortunately, Tony’s too incredible to be believed stem cell miracle – in less than 72 hours- may set people up for disappointment. Stem cell therapy doesn’t take effect like a pain killer – at least for most people.

To be clear, Tony, Trish, and many other AMBROSE Cell Therapy patients report sustained benefits from a single treatment. But they improved for months or even years before they plateaued.

With all that said, we applaud Tony’s stem cell advocacy. He gives hope to 10’s of millions of people living with debilitating conditions unsatisfied with conventional and integrative medicine.

Back to Tony’s Story
Tony’s story begins: “I have to admit, I was acting more like a 14-year-old at the time, tearing down a mountain in Sun Valley, Idaho, on my snowboard. It went horribly wrong, and I fell with a bone-rattling force that annihilated my shoulder.

It turned out that I’d torn my rotator cuff, the set of tendons and muscles connecting the upper arm to the shoulder. Over the years, I’d dealt with lots of pain. This hurt so brutally that I didn’t know what to do with myself. On a scale of one to ten, I’d award this pain a score of 9.9!    My nerves were on fire. Deep breaths even hurt. Over the next two nights, I slept a grand total of two hours.” Ouch.

The melodrama continued. More on that in a moment, first let us fact-check Tony’s science presentation.

Fat Fact-checking
The cognitive bias begins when Tony credits Dr. Bob Hariri with discovering stem cells in placentas doomed for the dumpster. Then Bob tosses “autologous fat-stem cells” into the medical waste in two ways. He fails to mention:

1. Zuk et al.’s 1999 discovery in a UCLA lab that adipose tissue is the most accessible, abundant, and potent source of mesenchymal stem cells (MSCs), and

2. Adipose tissue contains a mixed population of stem cells and other regenerative cells. Researchers call these autologous Adipose-Derived Regenerative Cells or ADRCs.

He reasons that stem cells from bone marrow, skin, or adipose tissue decline in number and potency as we age. Hariri calls this process stem cell exhaustion. Thus, he argues cultured allogeneic or donor placental-derived MSCs (PD-MSCs) are pristine. Umbilical-cord-derived MSCs (UC-MSCs) are next best. The hypothesis is making sense – so far.

But just because it’s logical doesn’t mean it’s true. James Willerson, MD, Ph.D., and Emerson Perin, MD, Ph.D., from Texas Heart Institute, contradicted Bob’s argument in Buying New Soul (2012).[1]

Adipose tissue seems to be a promising source of stem cells…The resiliency of adipose tissue is evidenced by patients’ ability to gain weight easily even in the presence of multiple comorbidities known to inhibit stem cell function. It may be that certain tissues are less exposed to the detrimental effects of disease and aging.”

Notably, investigators have published over 85,000 papers discussing adipose-derived stem cells (ADSCs). That is an average of 11 new publications per day over the past 22 years. The publishing rate has accelerated to 36 per day, nearly four times the historical average.

A PubMed search finds less than half as many publications on Placenta-derived stem cells (PDSCs).

Jack Nicklaus’ Stem Cell Therapy Hole-in-One
After Bob gave fat a lousy score, Tony recounted meeting Jack Nicklaus at the Vatican Stem Cell Summit. Here, Jack told the audience about his stem cell therapy hole-in-one. Stem cells “helped me go from not being able to stand for longer than 10 minutes, to playing golf and hitting the tennis ball again without pain. They will dramatically enhance your life!”

Apparently, Tony didn’t know prof Dr. Eckhard Alt treated Jack’s back with ADRCs. The your-fat-stem cells-are-too-old theory missed the cut here: Jack was in his late 70s when he opted to go to Germany for autologous ADRCs.

Note, Jack said “helped me” – stem cells are the fertilizer – physical therapy, appropriate exercise, and a healthy lifestyle are the gardeners that restore health.

Finally, our groups in the Bahamas and the U.S. have treated ~400 patients with ADRCs.

We counted every patient’s total nucleated cell (TNCs) with the NucleoCounter. A TNC contains DNA, which makes the cell active. Red blood cells do not have a nucleus and thus have no therapeutic effect. A review of the stats proves Dr. Willerson’s point: ADRCs’ yield, viability, and, most important, outcomes do not suffer from age.

Two over-70 patients with multiple morbidities hold the male and female records for highest yields and viability.

  • Nancy, a skinny long-term smoker with COPD, arthritis, and dermatitis, and
  • Bob, an obese man with polyarthritis, a rare neurologic condition, migraine headaches, and frailty.

On the other side of the coin, a 15-year-old spinal cord injury patient’s yield was right up there with Bob. Six months post-cell therapy and more than one year after his catastrophic injury, the young man regained bilateral motor control of his hip flexors and quads. Standard of Care SCI patients plateau at about 12-months – remarkably, this young man’s path is accelerating.

Most profound, our patients with multiple chronic conditions, including diabetes, heart, kidney, and autoimmune diseases – including obese patients – report high patient satisfaction.

Back to Tony’s story
Three specialists advised surgery. Then one injected PRP but must have hit a nerve as Tony’s arm went limp while performing. Next, a doctor recommended Pulsed Electro-Magnetic Field Therapy (PEMF). PEMF helped: His pain score reduced to 4.5. Tony continued PEMF until he arrived in Panama. Presumably, his pretreatment score pain was lower still.

The Panama clinic gave him three IV shots of umbilical cord-derived mesenchymal stem cells (UB-MSCs) over three days. On the first day, a doctor injected stem cells into his shoulder – but not his back.

On day two, Tony had an adverse event: “…I had what’s often called a “cytokine response.” I felt chills and shaking, but I wasn’t scared. They told me it was normal: “Your body’s healing, just get some rest.”

At the risk of offending Tony or the clinic staff: A cytokine response is an abnormal reaction.    The body’s immune system recognized the donor stem cells as foreign (or contaminated). These reactions do not occur with autologous ADRCs.

By the way, we respect Neil Riordan, Ph.D., CEO of the Stem Cell Clinic of Panama. He co-authored three early, highly cited papers on stromal vascular fraction (the generic term for ADRCs).

Recent research clarifies that donor stem cells are “immune-evasive, not immune-privileged,” counter to the proponents of allogeneic cell therapy.[2] [3] Simply put, the Panamanian UB-MSCs and Tony’s immune system were not a perfect match. Married couples fight from time to time but can still be happy. Perhaps, that was the case with Panama clinic’s Golden Cells. They had a little spat and got on with it.

Thankfully, Tony says the shaking lasted 20 minutes. He did not allow how long the chills lasted or if he caught a fever. Published clinical trials report allogeneic MSC infusions often cause transient fevers. This side-effect is mild, particularly compared to the risks of surgeries, drugs, and devices.

Miraculously, 15 years of back pain and shoulder pain were gone for good on the third day, Tony stated. He does not specify if the injection doctor was board-certified in pain management. Of if the shoulder injections were done under ultrasound? As one reads on, the story gets confusing.

The stem cells took effect on day three – but we don’t know for how long or how much.

And here is the rub: The continuing story makes it hard to attribute the awe-inspiring, new-life proclamation to life force UB-MSCs alone. That is ok – if Tony’s fans understand that. First, his shoulder may not have been in that much pain, thanks to the PEMF and conventional care, i.e., ice, PT, and rest. And resting during the three-day protocol may have decompressed his spine.

Plus, he indulges in multiple biohacks per day for pain and inflammation.

Here is the point: Unrealistic expectations lead to disappointed patients. But they are thrilled when stem cell therapy helps them live a better life.

As Tony’s research, therapy, and investment journey twists and turns like Jack’s back did when he played the PGA tour, Tony accesses innumerable tools for his health:

  • Cryo-therapy,
  • Counter-strain physical therapy,
  • Laser therapy
  • Hyperbaric oxygen therapy,
  • PEMF therapy
  • Egoscue exercises,
  • Supplements,
  • Sauna,
  • Exosomes,
  • Stem cells, etc.

Last but not least, his story double-bogeyed with exosomes, nano-sized sacs of growth factors secreted from MSCs. “I personally used exosomes along with stem cells to address a variety of challenges I experienced as a result of the work I had done on my shoulder that I told you about in Chapter 2,”

What? Tony said Panama stem cells resolved those challenges on Day Three.

For reasons best known to biohackers and God, there is a growing misbelief that exosomes are more effective than MSCs. That science discussion is beyond the scope of this review. Suffice to say, MSCs release exosomes, growth factors, hormones, and anti-inflammatory cytokines in a single dose.

Significantly, ADRCs secrete hundreds more healing or trophic factors than cultured MSCs do alone.[4]  All these attributes place clinical-grade ADRCs at the top of the leader board.

However, that doesn’t mean PD-MSCs, UB-MSCs, and BM-MSCs aren’t effective. They can shoot par. But safety and effectiveness depend on complying with Good Lab Practices (GLPs), the culturing method, and other technical specifications. Pew Trusts exposed contamination-related adverse events when doctors treat patients with cheap and cheerful stem cell products.

AMBROSE’s use of the Celution™ cell processing system and compliance with the Federal Right to Try Act of 2017 underpins our pristine cell-related safety record.

Tony is a Humanitarian. He has inspired millions of people to live better lives and means Life Force to do the same thing. His 1100-page 17-hour listen does so.

However, he diluted his sincere intentions with cognitive bias, contradictory evidence, conflicts of interest, and hyperbole. Our forensic review of the stem cell commentary suggests other information in the book suffered the same fate.

Life Force is a best-seller.

[1] J. Willerson and E. Perin Buying New Soul J Am Coll Cardiol. 2012;60(21):2250-2251

[2] Berglund et al. Immunoprivileged no more: measuring the immunogenicity of allogeneic adult mesenchymal stem cells Stem Cell Research & Therapy (2017) 8:288

[3] Akrum et al Mesenchymal stem cells: immune evasive, not immune privileged Nat Biotechnol. 2014 March ;32(3):252–260

[4] Hirosi Y et al. Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/ stem cells in the same individuals

AMBROSE Cell Therapy

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The Power of Simplicity in Health and Wellness

The Power of Simplicity in Health and Wellness

The Power of Simplicity in Health and Wellness

We often undervalue the Power of Simplicity in our health and wellness.

At one end of the spectrum, the standard of care extends our lifespans, i.e., drugs, surgery, and devices.But the average senior sees seven doctors and takes seven meds per year. Thus, we all know someone – or are that someone – who lives with a poor quality of life.Self-proclaimed biohacking broscientists are on the other end of the spectrum.If something might just help your health – no proof required- one of the broscientists will sell or promote it. In doing so, they claim their products, equipment, books, podcasts, and psychedelic drugs are the solution to everything from chronic disease to healthy aging.

The Power of Simplicity
Instead, you can be the hero of your health by taking control of your mind and body with simple lifestyle practices. Better yet, these tools cost nothing but a bit of time. And they bring enjoyment to you and others with whom you live, work, and play.

The pillars of healthy aging are moderate exercise, an anti-inflammatory diet, a strong family, and fun, supportive friends. It’s “too simple.”

  • Study after study demonstrates walking would be a trillion-dollar drug – if big pharma could put it in a vial and sell it. Healthline says their top 10 benefits include heart health, lower blood sugar, boosted energy, living longer, creative thinking, and more.
    A trial led by the University of Massachusetts found that walking about three miles per day cut the risk of dying by more than half. Surprisingly, people who walked further or faster did not live longer. According to the Cleveland Clinic, too much exercise can hurt you. In other words, you don’t have to be a weekend warrior to be healthy.
  • The Harvard School of Public Health supports the age-old Mediterranean diet. If you start the Mediterranean diet before the age of 80, you will outlive at least three of your friends who eat the western diet. Our Italian, Spanish, and Greek friends who consume more olive oil, fruits, vegetables, nuts, and seafood than Americans have a lower risk of heart disease, stroke, dementia, and depression.
  • Dan Buettner studied five communities in Japan, Italy, Greece, Costa Rica, and California. In these five Blue Zones, more 90-year old’s live with vim and vigor than anywhere else on the planet. His talk, How to live to be 100+, ties together the common denominators regarding exercise, diet, community, and purpose that Buettner’s research unearthed. Suffice to say, people in these communities walk a lot.
  • At 33, Lissa Rankin, M.D., was a burned-out ob-gyn physician. She was taking seven medications to treat a whole host of conditions.  Her successful search for better personal health led Lissa to mind-over-body medicine.  In her TEDx Talk, Is there scientific proof we can heal ourselves?, Lissa names research studies that show friendships, long-term relationships, a positive frame of mind, and relaxation exceed the benefits of exercise and diet alone.
  • In Shut your Mouth and Change your Life, Patrick McKeown explains how simply switching from mouth breathing to nasal breathing improved his asthma, sleep, and focus. Gentle, slow nasal breathing enhances heart health, lung function, sexual fitness, immune strength, and a heightened sense of well-being. He gives new meaning to a breath of fresh air. And breathwork isn’t new: Medical research attributes the benefits of meditation and yoga to it.

But for some people, healthy living isn’t enough, or it came too late.  After failing conventional and integrative medicine, Barbara, Jeff, Tony, Trish, and others credit accessing their adipose-derived stem and regenerative cells (ADRCs) with their improved quality of life. In this way, ADRCs bring a Golden Era of Self-Cell Repair to healthcare.

In summary, these mind-body wellness tools are the keys to the healthspan kingdom.

Conversely, extreme biohacking may just be the new stupid.  In this realm, “broscience” geniuses Dave Asprey, Joe Rogan, and Ben Greenfield score healthcare IQs below the room temperature.

Like big pharma, biohacking is big business. If we stacked on top of one another all the equipment, products, supplements, coffee, food, books, course materials, franchise documents, blog posts, and transcripts the big three market, it would be the height of a 10-story super-store.

The polar opposites are the stars of the back-to-basics formula.  They are everyday folks who enjoy life into their 80s, 90s, and 100s with intact memories, healthy hearts, and rich social lives.

 

The millions of scientific papers supporting the Power of Simplicity in health could encircle the earth.On a personal basis, the pillars of the Power of Simplicity encompass the future of healthy, happy, and dignified aging. And you can splurge on them without having to spend any money at the Biohacking Superstore.

AMBROSE Cell Therapy

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Is a Golden Era of Spine Care Ahead?

Is a Golden Era of Spine Care Ahead?

Is a Golden Era of Spine Care Ahead?

In 2016, Barbara suffered from debilitating spinal stenosis. After failing to respond to chiropracty, physical therapy, medication, and steroids, Barb accessed a new option: The stem cells and other regenerative cells residing in her fat or adipose-derived regenerative cells (ADRCs). Five years since her treatment, Barb says that cell therapy “saved my future.”

In 2018, Trish, Jeff, and Kathy lived with complex, debilitating health conditions, including spine-related pain. After they had failed to get relief from conventional and integrative medicine, each chose to exercise their Right to Try AMBROSE Cell Therapy under the Federal Right to Try Act of 2017. Remarkably, over two years post-cell therapy, they all report their spine-related symptoms and dysfunction don’t hold them back anymore. But what is the scientific back story that led to their sustained outcomes? And what was the catalyst for a Golden Era of Spine Care?

 Is Conventional Spine Care Antiquated?
Spine care has its origins in antiquity. The Edwin Smith surgical papyrus, an Egyptian document written in the 17th century BC, is the first known discussion of neck and back-related injuries. Hippocrates (4th century BC) experimented with traction or local pressure to correct spinal deformities. Aristotle also contributed to our current day understanding of the neck and spine.

Few individuals in history have made as many contributions to so many disciplines as Leonardo da Vinci. Included in his vast body of work, Da Vinci sketched the first accurate depiction of the spine. [1]

As a result, knowledge of the neck and back, and their related disorders, have evolved since the Renaissance Man’s illustrations.

Early researchers proposed that neck and back pain resulted from the stress of heavy loads and age-related wear and tear on the discs. Then, in 1978, White and Panjabi published Clinical Biomechanics of the Spine. Here, they connected all the mechanical factors involved in neck and back health.  Technically speaking, they found that in addition to vertebrae, our muscles, tendons, ligaments, blood vessels, and nerves (soft tissues) play significant roles in spine health and disease. White and Panjabi named those pieces of the puzzle the Functional Spine Unit (FSU).

But there was still more to be discovered than the FSU. More recently, researchers began focusing on the vicious interplay involved with traumatic injuries, wear and tear, inflammation, and other diseases (co-morbidities). For example, patients with heart disease, diabetes, neurologic conditions, and autoimmune diseases have a higher prevalence of spine disorders than others without those conditions. In fact, Barb, Trish, Kathy, and Jeff each lived with other chronic debilitating conditions, including arthritis, hypermobility, kidney failure, and spinal cord injury, respectively. [2] [3] [4] [5]

In 2001, Patricia Zuk, Ph.D. et al., working in a UCLA lab, accomplished a (non-obvious) leap forward for patients living with neck and back pain. Zuk’s group discovered mesenchymal stem cells (MSCs) were residing in adipose tissue. But how did their seemingly unrelated research catalyze a Golden Era of Spine care? We will answer that in a moment first; why was a new regenerative option needed in the first place?

 Failed Back Surgery Syndrome
Despite those thousands of years of research and development, more people than ever are suffering from spine-related pain. Besides contributing to the opioid epidemic, the number of spine surgeries increases year in and year out.

Unfortunately, downsides to spine surgery, including high rates of complications, readmissions to the hospital, and poor outcomes, are common. [6] [7] As a result, approximately 4 million individuals live with failed back surgery syndrome (FBSS) in the U.S. Tragically, a spinal fusion gone wrong caused Jeff’s spinal cord injury.

Doctors call those with FBBS and others unwilling to risk a surgical intervention “no-option patients. Jeff’s spinal cord injury resulted from a spine surgery, which upon a second opinion, turned out to be unnecessary in the first place. Barb, Kathy, and Trish opted not to pursue surgery out of concern for those risks.”

 Is there more to spine health than meets the eye?
Circling back, in the early 1500s, Leonardo da Vinci took an unusual interest in tree anatomy. His Rule of Trees explained the balance between the trunk and branches of a tree. He counted the rings in tree trunks to determine “the nature of past seasons.”

Perhaps it wasn’t coincidental that he sketched the spine, tree trunk, and branches, respectively? Let’s look at it this way: The tree’s trunk supports the crown and branches. Likewise, a healthy neck and back do the work of a strong tree.  But even the strongest and thickest tree branch cannot handle a heavy load if the tree’s trunk is weak. Similarly, our legs, arms, hands, and feet can be affected by a degenerated FSU.

Ideally, our spines are a harmony of functional bones and soft tissues. The back and neck rely on all those elements to hold us upright and be mobile. But when the soft tissues atrophy or become arthritic, they pressure nerves, thus contributing to spine-related symptoms.

  • Trish lived with sciatica, numbness, stiffness, and pain.
  • Kathy’s bad neck kept her awake at night.
  • Barbara’s situation prevented her from working, gardening, driving, and pottery.

Most vexing, back-related discomfort doesn’t discriminate: Gardners, crossfitters, weightlifters, golfers, and aging couch potatoes can end up unable to function without pain for varied reasons. [8]

ADRCs – the Spine’s Arborist
An arborist cultivates trees; tree removal is a last resort. The first thing that goes through their minds is how to save the tree. To do their jobs, arborists cultivate the whole tree. They use fertilizer, irrigation, and other regenerative tools to restore the tree’s trunk, limbs, and leaves.

Around 2010, Zuk’s discovery of stem cells in fat came into play when some innovative doctors began treating spine patients with ADRC-based protocols. Their strategy was not dissimilar to an arborist’s. They recognized that a veritable pharmacopeia in a person’s fatty tissue could reduce arthritis and regenerate the supportive soft tissues in the neck and lower back. Back surgeries change the anatomy while cell therapy is, well, therapeutic.

Just as an arborist uses an array of skills to rehabilitate diseased trees, ADRCs use multiple mechanisms of action to rehab the FSU. At least as necessary, ADRCs restore balance or homeostasis in the systems that feed, care for, and defend the spine. In other words, better vascular, immune, metabolic, and nervous system wellness contributes to overall improvements.

In summary, not only did AMBROSE cell therapy help Barb, Jeff, Kathy, and Trish avoid risky surgeries, but all reported being more active, increased energy, and an improved sense of wellbeing.

[1] Bowen G et al Leonardo da Vinci (1452–1519) and his depictions of the human spine
Childs Nerv Syst (2017) 33:2067–2070

[2] M. Shamji et al. Proinflammatory Cytokine Expression Profile in Degenerated and Herniated Human Intervertebral Disc Tissues Arthritis Rheum. 2010 July; 62(7): 1974–1982

[3] J Gallo Inflammation and its resolution and the musculoskeletal system J Orthop Translat. 2017 July; 10: 52–67

[4] Asadian et al. Diabetes Mellitus, a new risk Factor for lumbar spinal stenosis: a Case–Control study. Clinical Medicine Insights: Endocrinology and Diabetes 2016:9 1–5

[5] Lotan R, Oron A, Anekstein Y, Shalmon E, Mirovsky Y. Lumbar stenosis and systemic diseases: is there any relevance? J. Spinal Disord. Tech. 2008;21(4):247-51.

[6] Camino Willhuber et al. Analysis of Postoperative Complications in Spinal Surgery, Hospital Length of Stay, and Unplanned Readmission: Application of Dindo-Clavien Classification to Spine Surgery Global Spine Journal July 2018

[7] Chase D. The opioid crisis is partly fueled by insurers and employers’ approach to back pain. StatNews. statnews.com/2019/03/27/opioid-crisis-insurersemployers- back-pain/. Published March 27, 2019.

[8] J Abbas et al Paraspinal muscles density: a marker for degenerative lumbar spinal stenosis? BMC Musculoskeletal Disorders (2016) 17:422

AMBROSE Cell Therapy

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Has a Golden Era of Diabetes Care Begun?

Has a Golden Era of Diabetes Care Begun?

Has a Golden Era of Diabetes Care Begun?

Amy’s Six-Year Patient-Reported Outcome Suggests So.

After living with severe diabetic neuropathy and fibromyalgia, in 2014, Amy, a then 24-year-old T1 diabetic, accessed the stem cells and other regenerative cells in her fat (adipose tissue) to improve her quality of life. That single treatment of adipose-derived regenerative cells (ADRCs) marked the turning point in Amy’s battle with diabetes. Amy’s every day went from being ruled by her foot pain to playing soccer, hiking the Grand Canyon, and living life to the fullest.

Amy didn’t go on a highly restrictive diet or make radical lifestyle changes on her way to improved symptoms, function, and quality of life. That isn’t to say those tools aren’t helpful for some; Amy just didn’t need them after cell therapy. Neither are we saying that her food choices and exercise regimens weren’t healthy; they just weren’t extreme.

To put Amy’s patient-reported outcome in perspective, let’s contrast it with the standard of care for chronic disease. A single dose of medicine rarely, if ever, provides lasting benefits. We often take prescribed drugs for life – unless they don’t work or the side-effects are not bearable by the patient.

Seniors, on average, take seven medicines and see seven doctors per year.

Those pursuing a more natural route take supplements daily, repeat integrative therapies for extended periods, go to the chiropractor when their bones and muscles go out of tune, and so forth.

The standard of care for people living with diabetes, concurrent with other diseases (co-morbidities) requires the patient to take multiple drugs daily to address each condition.

Not to be glossed over, Amy’s improvement for multiple morbidities resulted from a single, same-day treatment with ADRCs. Her benefits from cell therapy have now spanned more than six years and continue. If Amy needs a repeat treatment at some point or another, her win would still indicate a new standard of care for patients living with diabetes is afoot.

Or, as better put by Amy, instead of living in constant fear of her next flare, she can dream again. Broadly speaking, ADRC-based treatments bring creditable hope to people living with diabetes and related illnesses.

Notably, other tools can provide significant benefits to people with diabetes. For people living with T1D like Amy, continuous glucose monitoring (CGM) paired with an automated insulin pump makes a positive difference. For those with T2d, diet and managing blood sugars with CGM can change the disease’s progression or, if caught early enough, reverse it.

Amy’s self-cell therapy (using ADRCs) changed the course of her life. Her results and others like her signal that a Golden Era of  Diabetes Care has begun.

You can find Amy’s Patient-Reported outcome here.

AMBROSE Cell Therapy

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