Select Page
Is There a Golden Era of Cell-Assisted Brain Care Ahead?

Is There a Golden Era of Cell-Assisted Brain Care Ahead?

Is There a Golden Era of Cell-Assisted Brain Care Ahead?

Muhammed Ali’s 1960 Olympic Gold medal started his ascent to being “The Greatest,” but the countless blows to his head – which he welcomed to tire his opponent out – ended in a years-long failed fight to save his brain.

In 2016, Parkinson-related issues took his life, though not before he sought out adult stem cell therapy. Unfortunately, Congress had not yet passed the Federal Right to Try Act of 2017.

What if those who first observed Ali’s slurring, shuffling, and memory struggles had known about the healing factors adipose-derived stem and regenerative cells (ADRCs) secrete?
And what if Ali had the Right to Try to access his ADRCs?

Would he have resumed floating like a butterfly and stinging like a bee? No, but that’s not the point, either.

Ali would have had a fighting chance at a better quality of life. Instead, he faced a decades-long struggle with his Parkinson’s symptoms and the PD drug’s side effects of nausea and tremors, not to mention the other medical conditions with which he lived.

Ali’s descent is a stark example of the risks of brain injuries to our long-term brain health.[1] And these risks are not unique to him or boxing.

Tim’s Win
“I raced in hundreds of powerboat races. Maybe I’m lucky…maybe I’m blessed…maybe I’m genetically superior…or maybe I’m all three, with help from my ADRCs!” says Tim.

In 2000, Tim retired from offshore powerboat racing with four world speed records. He once hit upwards of 180 mph.

Arguably more at risk than Ali, he suffered innumerable head traumas, lost consciousness, and survived a near-death coma on the way to winning his Gold Medals.

In the early 2000s, Tim’s family and friends noticed his hands shaking. In 2008, a neurologist diagnosed him with essential tremors.

Essential tremor is a nervous system (neurological) disorder that causes involuntary and rhythmic shaking. It can affect almost any part of your body, but the trembling occurs most often in your hands — especially when you do simple tasks, such as drinking from a glass, handwriting, or tying shoelaces.

“The cause was a breakdown in the electrical connections in the nervous system due to adverse trauma,” Tim’s neuro explained. He forecasted continued deterioration.

Essential tremors are a suspected risk factor for Parkinson’s disease.[2] And as discussed in detail below, concussions significantly increase the risk of Alzheimer’s, Parkinson’s, ALS, and other neurodegenerative disorders.

Tim’s powerboat racing magnified the risk from contact sports. “It’s been determined that offshore race boat drivers experience more G forces in one race than all the astronauts in the history of NASA have experienced put together. The impact would come up your spine. My head would wobble like a bobble doll,” Tim explained.

“I must have had 1,000 concussions while racing. I probably went unconscious 100 times behind the wheel from the G-forces,” Tim estimated.

Before Tim had the “need for speed,” he played high school and college football. “This was in the days long-before helmet-on-helmet rules, and concussion protocols were in place. I remember getting hit in the head, going to the wrong sideline, and being put right back out on the field”, he recalled.

Tim also tells about his near-catastrophic motorcycle accident when he was a teen: “No helmet, of course…in the hospital for ten days…coma, severe concussion.”

Tim’s Right to Try
In March 2016, Tim accessed his ADRCs offshore with AMBROSE’s prior group. (Okyanos Cell Therapy, Freeport, Bahamas). Almost seven years later, he said, “I should be in much worse shape than I am.”

“My tremors are barely noticeable to other people now. I can eat soup without losing 2/3s of it between the bowl and my mouth. My writing isn’t perfect like I learned in Catholic school growing up, but I can sign checks and write legibly. My memory is fine.”

“The benefit of the stem cells is that it reconnected the wiring,” said Tim.

Tim credits his ADRCs-based cell therapy with other unexpected benefits:

  • “I wore glasses when I raced and before my treatment. Afterward, my vision improved to 20/20. I no longer wear glasses, including readers.” Tim is 63 years young.
  • After all the pounding on my ears and brain from racing and playing the drums in high school, I expected to be deaf by now.” he half-joked. “Instead, my hearing, senses of smell, and taste are better than they were before.”

Remarkably, Tim only recently developed high blood pressure and has no joint or spine issues.

Given Tim’s baseline and absence of other interventions, it would be difficult to attribute his sustained six-year improvement to anything other than his ADRC-based treatment.

Thus, we foresee a Golden Era of Brain Care ahead. More on that in a moment; first, some background.

Background
In the late 1970s, boxing fans observed changes in Muhammed Ali’s speed and speech. Others noted that Ali seemed bored and emotionally detached. The Greatest estimated his opponents hit him in the head 29,000 times – that is like being whacked in the skull day in and day out for 79 years.

And even in fights that he won, Ali took some vicious beatings, especially later in his career. He described the epic third fight with Joe Frazier, in which Ali retained his title after 14 brutal rounds, as “the next thing to death.”

In 1984, three years after retiring from the ring, Ali was diagnosed with Parkinson’s Disease (PD). At that time, doctors did not link the brutal poundings with PD.

Further, TBI research did not associate Ali’s brain damage with chronic traumatic encephalopathy (CTE), the term researchers use to describe a disease of the brain (encephalopathy) caused by repeated head traumas.

Nor did his doctors connect CTE to his frequent bouts of pneumonia, infections, or dementia.

Ali’s descent is a stark example of the risks of brain injuries to our long-term brain health.[3] And these risks are not unique to him or boxing.

CTE is Pervasive
Will Smith’s movie, Concussion brought public awareness to the devastation too many football players face later in life. NFL players are paid big bucks for taking three times the risk of dying from brain disorders than the fans watching them. That risk expands to four times for Alzheimer’s and ALS, respectively.[4]

In 2017, the Journal of the American Medical Association published a study revealing bleak futures for former NFL players. Their median age of death was just 67, and out of the 111 post-mortems, 99% — were diagnosed with CTE.

CTE symptoms vary depending on how advanced or severe it is, but people may experience memory problems, mood disorders, depression, and lapses in judgment.

Brain Trauma – Adding Insult to Injury and Injury to Insult

Brain trauma can be mild or minor, severe, or significant. You don’t have to be an NFL player, a boxer, or race powerboats to increase the probability of Alzheimer’s, Parkinson’s, and other neurologic problems.

After head trauma, some victims recover right away, but many suffer from a constellation of disturbances, including fatigue, poor memory, insomnia, pain, vision, speech, and balance difficulties. [5] [6]

Going the Distance from Brain Science to Brain Care
Ali had another fight separate and apart from his Parkinson’s battle: The chasm between the known factors contributing to neurological conditions and the treatment options available to patients suffering from them.

The gap became apparent in 2006 when Dr. William Langford, the first Chief Science Officer of the Michael J. Fox Foundation, published Parkinson’s Complex: Parkinsonism Is Just the Tip of the Iceberg.[7]

In short, Dr. Langford’s seminal paper stated PD was not limited to the loss of dopamine-producing neurons in the substantia nigra. Instead, Parkinsonism involves multisystem breakdowns. Therefore, he said, “Rather, we must deal with all aspects of the disease if we are to modify its progress in a way that truly enhances the lives of our patients over the long term.

Subsequently, researchers discovered the same interconnected dysregulations after a TBI, stroke, spinal cord injury, Alzheimer’s, etc. Brain diseases don’t pull any punches – they spare no physiologic system.

To solve for this, doctors prescribe patients drugs for each ailment or symptom, e.g., Sinemet for Parkinson’s, Ambien for sleep, steroids for arthritis, opioids for pain, and so forth.

Drug side effects include accelerating the decline in cognitive function.[8]
Dr. Armon Neel Jr. cautions that ten drug classes contribute to dementia progression.

Multisystem dysregulation is a chicken and egg problem. Nearly all patients with brain degeneration live with multiple chronic conditions (co-morbidities).

Tim’s ADRCs – Miracle-Gro For His Brain
Miracle-Gro feeds your garden’s soil with the nutrients it needs to grow healthy roots, stems, petals, and leaves. And just as there are situations in which we fertilize a plant lacking vital nutrients, ADRCs secrete growth factors essential to the health of our aging brains, hearts, muscles, nerves, and so on. [9]  Growth factors (GFs) are a type of cytokine or healing molecule that act on other cells to stimulate growth and function.

One such growth factor group is “Neurotrophic factors (NTFs).” Neuro relating to nerve and trophic, from Ancient Greek trophikós, meaning “of food or nourishment.” In other words, NTFs feed our neurons and nerves with nutrients.

Brain-derived neurotrophic growth (BDNF) stimulates new brain cells, brain cell connections, and nerves. It also repairs the myelin sheathing surrounding the nerves.

It gets better: BDNF is anti-inflammatory and prevents programmed cell death (apoptosis) resulting from an injury or disease. [10] [11] [12] [13] [14]

Many benefits are associated with higher levels of BDNF, including improved mood, productivity, and memory. One 10-year study that tracked BDNF levels in adults found that those with low levels were twice as likely to develop dementia and Alzheimer’s than those with the highest levels.[15]

John Hopkins researchers developed a BDNF-blood test that could have predicted the severity of Ali’s head damage and how he would fare. Their study showed that patients with brain injuries have less than one-third of the BDNF as those with healthy brains.

The most severe TBIs had even lower levels- about 5% of normal. Moreover, patients with high levels of BDNF recovered from their injuries six months later. But symptoms lingered at follow-up in patients with the lowest levels of BDNF.[16]

ADRCs also enrich the brain with vascular endothelial growth factor (VEGF). VEGF restores blood flow and reduces inflammation in withering tissues, blood vessels, and organs. One study found higher levels of VEGF in asymptomatic seniors who died with amyloid plaques compared to symptomatic Alzheimer’s patients.

Notably, ADRCs secrete dozens of other healing factors.[17]

In combination, ADRCs restore multisystem balance or homeostasis – at the cellular, tissue, organ, and multisystem levels.

By the way, big pharma can’t discover a single molecule they can sell millions of copies of per year that can restore physiologic balance. Their drugs suppress the disease’s presumed- but often wrong -causes.

Thus, we believe Ali could have benefited from accessing his ADRCs. The medical literature supports it – and so does Tim’s powerful reversal of his symptoms. If only Ali had the Right to Try. [18] [19] [20] [21] [22] [23]

[1] Ledreux A, Pryhoda MK, Gorgens K, Shelburne K, Gilmore A, Linseman DA, Fleming H, Koza LA, Campbell J, Wolff A, Kelly JP, Margittai M, Davidson BS and Granholm A-C (2020) Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers. Front. Neurosci. 14:761.

[2] Tarakad A, Jankovic J. Essential Tremor and Parkinson’s Disease: Exploring the Relationship. Tremor Other Hyperkinet Mov (N Y). 2019; 8:589. Published 2019 Jan 9.

[3] Ledreux A, Pryhoda MK, Gorgens K, Shelburne K, Gilmore A, Linseman DA, Fleming H, Koza LA, Campbell J, Wolff A, Kelly JP, Margittai M, Davidson BS and Granholm A-C (2020) Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers. Front. Neurosci. 14:761.

[4] Lehman EJ, Hein MJ, Baron SL, Gersic CM. Neurodegenerative causes of death among retired National Football League players. Neurology. 2012 Sept 5 [Epub ahead of print].

[5] R. Jorge et al Major Depression Following Traumatic Brain Injury Arch Gen Psychiatry/Vol 61 Jan 2004

[6] D. Nampiaparampil   Prevalence of Chronic Pain After Traumatic Brain Injury A Systematic Review. JAMA.2008;300(6):711–719.

[7] Langston J W The Parkinson’s Complex: Parkinsonism Is Just the Tip of the Iceberg Annals of Neurology Vol 59 No 4 April 2006

[8] Ishii N et al. Polypharmacy Associated with Cognitive Decline in Newly Diagnosed Parkinson’s Disease: A Cross-Sectional Study Dement Geriatr Cogn Disord Extra 2019; 9:338–343

[9] A Caplan PhD MSCs: The Sentinel and Safe-Guards of Injury J. Cell. Physiol. 231: 1413–1416, 2016.

[10] Razavi, Shahnaz et al. “Neurotrophic Factors and Their Effects in the Treatment of Multiple Sclerosis.” Advanced Biomedical Research 4 (2015): 53. PMC. Web. 28 Sept. 2018.

[11] J. K. Huang et al Myelin Regeneration in Multiple Sclerosis: Targeting. Endogenous Stem Cells., The American Society for Experimental NeuroTherapeutics, Inc. 2011

[12] T Lopatina et al. (2011) Adipose-Derived Stem Cells Stimulate Regeneration of Peripheral Nerves: BDNF Secreted by These Cells Promotes Nerve Healing and Axon Growth De Novo. PLoS ONE 6(3): e178991

[13] S.  Seigo et al, Uncultured adipose-derived regenerative cells promote peripheral nerve regeneration, Journal of Orthopaedic Science, Volume 18, Issue 1,2013, Pages 145-151

[14] Xu et al Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis Journal of Neuroinflammation (2017) 14:156

[15] Jiao SS, Shen LL, Zhu C, et al. Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer’s disease. Transl Psychiatry. 2016;6(10):e907.

[16] FK K. Korley et al Circulating Brain-Derived Neurotrophic Factor Has Diagnostic and Prognostic Value in Traumatic Brain Injury JOURNAL OF NEUROTRAUMA 33:215–225 (January 15, 2016)

[17] Hirose, Yujiro et al. Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals Cytotherapy, Volume 20, Issue 4, 589 – 591

[18] JK Fraser PhD and S. Kesten MD Autologous Adipose Derived Regenerative Cells: A platform for therapeutic applications Advanced Wound Healing Surgical Technology International XXIX

[19] C. Tate and C Case. Mesenchymal Stromal Cells to Treat Brain Injury. Advanced Topics in Neurological Disorders.

[20] S Dobrowolski and G Lepski. Stem Cells in Traumatic Brain Injury. American Journal of Neuroscience 4 (1): 13-24

[21]CS et al. Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children. Neurosurgery 2011; 68: 588–600

[22] N Tajiri et al. Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats. J Neurosci. 2014 Jan 1;34(1):313-26

[23] Sharma et al Cell therapy attempted as a novel approach for chronic traumatic brain injury – a pilot study SpringerPlus (2015) 4:26

AMBROSE Cell Therapy

Your Right to Try

Can something be done for Covid Long-Haulers?

Can something be done for Covid Long-Haulers?

Can something be done for Covid Long-Haulers?

After living with severe long-Covid symptoms and pre-existing health conditions, Brian exercised his Right to Try AMBROSE Cell Therapy in November 2021. He says AMBROSE has had “a massive effect on my health and quality of life.” Brian adds, nine months out, “I am doing things I couldn’t do a month ago.”

Remarkably, Brian’s many benefits occurred despite ongoing business stress and the difficult loss of two family members.

BackgroundSince December 2019, SARS coronavirus 2 (SARS-CoV-2) has spread like wildfire across the globe.  Unlike the seasonal flu or cold, COVID-19 can attack all body systems and multiple organs.

In response to the virus’ scorched earth capabilities, stem cell researchers worldwide have collaborated to improve outcomes for high-risk Covid patients and long-haulers. [1]

The researchers drew from over 200,000 published papers on Mesenchymal Stem Cells (MSCs). By July 2022, their urgency resulted in 6,400 articles or around 12 daily.

The in-human MSC studies included Covid-induced:

  • Acute respiratory distress syndrome (ARDS) [2]
  • Multisystem inflammatory syndrome in children [3]
  • Multi-organ disease, including sudden cardiac arrest [4]
  • COVID-19 pneumonia in April 2020. [5]

Dr. Pietro Gentile and others focused their research on adipose-derived stem cells (ADSCs) and ADRCs.  [6] [7] [8] [9]

Can ADRCs help Covid Long-Haulers?

Most promising for Brian, his long-Covid symptoms intersected with those from hypermobility, concussions, renal failure, Lyme Disease, and post-chemo side effects.

In response to one or more of these insults, our ADRCs secrete growth factors (GFs) and anti-inflammatory signaling proteins or cytokines essential to our brains, hearts, muscles, nerves, cells, and body health in general.

We share more on GFs and cytokines in Brian’s story that follows.

Ambrose patients Trish, Wouter, Kathy, and other patients with brain fog, fatigue, joint pain, and so on responded to ADRC-based therapy.  Therefore, it made sense for Brian to try AMBROSE Cell Therapy.

Brian’s Story
In December 2020, Brian’s doctor admitted him to the Cedar-Sinai ICU with COVID-19, returning home as a Covid long-hauler after two weeks.

After an introductory call with CEO Matt Feshbach, AMBROSE provided an educational MD consult, overview articles, and peer-reviewed papers supporting the safety and potential effectiveness of the therapy for long-Covid and the other conditions affecting him. Brian said,” (Matt) answered my questions. I had sufficient understanding to move forward.”

Covid Long-Hauler Symptoms
Brian experienced classic long-hauler symptoms: brain fog, chronic fatigue, and emotional volatility. As he summarized, “Most of 2021 was a lost year.”

He started to notice benefits shortly after his AMBROSE treatment. “After about a month, I saw a massive improvement in my mental clarity and energy. Business associates said they noticed the difference too. I didn’t realize how bad the fatigue was until I regained my strength.”

Supporting Brian’s statements, ADRCs release “Neurotrophic factors (NTFs),” Neuro relating to nerve and trophic, from Ancient Greek trophikós, meaning” of food or nourishment.”  NTFs, through multiple mechanisms, reduce neuroinflammation and stimulate the development of new brain cells, brain cell connections, and nerves. [10] [11]

Just as fertilizers keep plants healthy and growing, neurotrophic factors work like Miracle Grow for the brain.

Brian’s restored energy and mental clarity make sense in light of the above.

Vasculitis
Covid left Brian with debilitating inflamed blood vessels and swelling in both legs, or vasculitis, an autoimmune condition. He also complained of constant numbness and tingling in both legs (neuropathy). The right leg was worse than the left.

“My vasculitis and neuropathy went away shortly following the treatment.”

In addition to the NTFs, ADRCs secrete Vascular Endothelial Growth Factor (VEGF). VEGF improves circulation, reduces inflammation, and stimulates the growth of new blood vessels.

Here again, it makes sense that Brian’s swollen blood vessels and nerves calmed down. And an abundance of literature supports Brian’s subjective experience. [12] [13]

And back to Brian’s brain: VEGF reduces neuroinflammation and improves blood flow in the brain. In contrast, neuroinflammation and lack of blood flow in the brain cause chronic fatigue, brain fog, and memory issues. [14] [15]

Pre-Existing Conditions
Brian entered the hospital with a galaxy of pre-existing conditions that had failed to improve with surgeries, drugs, and devices.

Before the pandemic, Brian lived with:

  • Obesity
  • Arthritis in his lower back, shoulders, hips, and knees
  • Asthma
  • Fractured ribs
  • Osteopenia (an early stage of osteoporosis) and
  • A mildly enlarged heart and shortness of breath

In summary, Brian suffered from multisystem dysregulation.

His medications included Prednisone 30-mg daily, Singulair, Symbicort, and Spiriva for Asthma. Ambien for sleep.

Can ADRCs help Covid long-haulers with pre-existing conditions?
In 2016 The California Institute of Regenerative Medicine (CIRM) contributed funding to two review papers that supported ADRC-based treatment for Brian’s chronic illnesses. Further, preeminent researchers from Tulane University and other respected research institutions have continued the growing support for ADRCs’ potential to treat multiple diseases. [16] [17] [18]

Obesity
Brian has struggled with his weight since a young age. “I have probably lost 300 lbs. throughout my life. I tried bariatric surgery in 2007 but gained the weight back.”

“Since my treatment, I have dropped about 50 lbs. and have maintained my weight within a lower range with a less restrictive diet for the first time.”

In 1994, super-sleuth Jeffrey M. Friedman of Rockefeller University established fat as an endocrine organ. In simple terms, he discovered adipose cells secrete hormones that regulate weight gain. His insight explains Brian’s improved metabolism and fat burning following his cell therapy treatment. [19] [20]

Wear, Tear, and Trauma
Brian played football in high school, resulting in some head traumas. He was involved in several major motor vehicle accidents in his early 20s. He went unconscious twice. “They took me to the hospital several times; it was pretty bad.”

Football, basketball, baseball, skiing, and excess weight was not kind to Brian’s joints either.

  • Three right-knee operations failed, leaving both knees painful.
  • He experienced degenerative arthritis in his shoulders.
  • His right and left hips were arthritic as well.

Steroid injections in the affected joints failed to give Brian relief. He tried bone-marrow stem cell injections for his shoulders, but that “didn’t work at all.”

Ambrose’s interventional pain specialist developed a personalized treatment plan based on a Master Protocol. He delivered 22 injections of PRP-enriched micronized fat into Brian’s painful joints.

A month out, his PT said, “Brian’s weight-bearing tolerance and conditioning are improving. He’s doing great.”

Eight months out, Brian shared, “My shoulder, hips, and knees feel good. My back is fine.”

Asthma
Brian developed asthma in his 40s after spending a month in China on business. Before his stem cell treatment, he used three inhalers and took 30 mg of prednisone daily.

Nine months after Brian’s AMBROSE treatment, he says, “I have lowered my daily prednisone dose to 10 mg and occasionally miss taking it without an asthma flare. I significantly reduced my use of inhalers, too.”

Fractured Ribs
An asthma-induced coughing attack fractured four ribs on March 1, 2018. After reviewing Brian’s x-rays, his orthopedist told him he could not repair the ribs. Additionally, Brian had an underlying diagnosis of osteopenia, a condition involving reduced bone mass.

Studies showed that ADRCs stimulate bone healing. [21]

The Ambrose physician injected the fractured ribs. Several months later, Brian reported, “My ribs feel like they healed. That is impressive” To be clear, he still experiences mild discomfort, “but nothing like it was before.”

Mildly Enlarged Heart
A 2018 cardiac workup revealed Brian had a mildly enlarged heart and shortness of breath.
His cardiologist and PT agree the shortness of breath is no longer evident.

The PRECISE cardiac cell therapy study demonstrated significant improvements in endurance, thus supporting Brian’s doctor’s observations. [22] A new cardiac workup is in order.

Multisystem Balance Restored
Brian’s patient-reported outcome demonstrates the potential to restore multisystem homeostasis (balance) by utilizing his ADRCs.

Recommending AMBROSE to Family and Friends
“I have recommended Ambrose to my mother and best friend. It makes sense for them to try it too. Both have arthritic joints, back pain, and other medical issues.”

 

 

[1] Yasamineh et al. Spotlight on therapeutic efficiency of mesenchymal stem cells in viral infections with a focus on COVID-19 Stem Cell Research & Therapy (2022) 13:257
[2] Wick K et al. Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS JCI Insight 2021;6(11):e148983
[3] Ross Eckard A, Borow KM, Mack EH, Burke E, Atz AM. Remestemcel-L therapy for
COVID-19-associated multisystem inflammatory syndrome in children. Pediatrics. 2021
[4] Yilmaz R et al. Mesenchymal stem cells treatment in COVID-19 patient with multi-organ involvement Bratisl Med J 2020; 121 (12) 847-852
[5] Zeng et al. Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia Aging & Disease Volume 11 Number 2; 216-228, April 2020
[6] Stromal Vascular Fraction or SVF is the generic term for clinical grade adipose-derived regenerative cells.
[7] Pietro Gentile, Aris Sterodimas. Adipose Stem Cells (ASCs) and Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating (COVID-19)-Disease. Aging and disease. 2020, 11(3): 465-469
[8] Alexander RW. (2020) Overview of COVID-19 Lung Damage Clinical Trial Using Cellular
Stromal Vascular Fraction (cSVF) and Functional Respiratory Imaging (FRI) Analysis of Pulmonary Injury
& Post-Viral (SARS-CoV-2) Adult Respiratory Distress Syndrome (ARDS). Stem Cell Res. 1(1)-1-19.
[9] Sanchez-Guijo F et al. Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study EClinical Medicine 000 (2020) 100454
[10] S. Seigo et al, Uncultured adipose-derived regenerative cells promote peripheral nerve regeneration, Journal of Orthopaedic Science, Volume 18, Issue 1,2013, Pages 145-151
[11] Xu et al Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis Journal of Neuroinflammation (2017) 14:156
[12] Liao L. Mesenchymal stem cell and hematopoietic stem cell transplantation for vasculitis. Vasc Invest Ther 2020; 3:88‐93.
[13] Jahangir S et al. New advanced therapy medicinal products in treatment of autoimmune diseases Editor(s): Nima Rezaei, In Translational Immunology, Translational Autoimmunity, Academic Press, Volume 2, 2022, Pages 319 359,
[14] Skok M. Mesenchymal stem cells as a potential therapeutic tool to cure cognitive impairment caused by neuroinflammation. World J Stem Cells 2021; 13(8): 1072-1083
[15] J Rosenstein, J Krum & C Ruhrberg VEGF in the nervous system Organogenesis 6:2, 107-114; April/May/June 2010; © 2010 Landes Bioscience
[16] Nguyen A et al. Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 170e179
[17] Guo J et al. Stromal vascular fraction: A regenerative reality? Part 2: Mechanisms of regenerative action Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 180e188
[18] Al-Ghadban S, Artiles M, Bunnell BA. Adipose Stem Cells in Regenerative Medicine: Looking Forward. Front Bioeng Biotechnol. 2022; 9:837464. Published 2022 Jan 13.
[19] Zhang, Y; Proenca, R; Maffei, M; Barone, M; Leopold, L; Friedman, JM (December 1994). “Positional cloning of the mouse obese gene and its human homologue”. Nature. 1994 (372): 425–432
[20] Zuccarini, M et al Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents. Int. J. Mol. Sci.
2022, 23, 1543.
[21] Saxer F et al. Implantation of Stromal Vascular Fraction Progenitors At Bone Fracture Sites: From A Rat Model To A First-In-Man Study STEM CELLS 2016; 00:00-00
[22] Perin E et al., Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: The PRECISE Trial Am Heart J 2014;168:88-95.e2.

AMBROSE Cell Therapy

Your Right to Try

A Golden Era of Cell-Assisted Aging

A Golden Era of Cell-Assisted Aging

A Golden Era of Cell-Assisted Aging

Back to the Future

For Mary, aging was not dying – it was disability; A transformative therapy, using her own Adipose-Derived Regenerative Cells (ADRCs), brought her Back to the Future.

In the summer of 2014, Mary’s doctor admitted her to the Cleveland Clinic ICU. After two weeks, the doctors sent her home with but one recommendation: Prepare for hospice.

Several months later, AMBROSE Cell Therapy’s predecessor group treated Mary with a novel ADRC-based protocol. Seven years after that single treatment, Mary celebrated her 93rd birthday with friends.

In 2021, Mary lived independently, her Parkinson’s symptoms were mild compared to her baseline, and her mood was upbeat. [1]  She exercised at the gym four days per week. Her back pain and sciatica had long since resolved.

Science Fiction Becomes Reality
Perhaps the renowned science fiction author Ray Bradbury foretold Mary’s outcome in The Illustrated Man, “She went back to the future,’ he said. ‘I mean it. She was an old woman in a little house in the middle of Wisconsin here, somewhere not far from this place. An old witch who looked a thousand years old in one moment and twenty years old the next, but she said she could travel in time. I laughed. Now I know better.’ “

Mary’s remarkable turnaround turned sci-fi into reality, as often happens with that genre. But how did Mary’s ADRCs help her time travel, particularly with the odds stacked against her?

Mary’s Story
By 86, Parkinson’s had disabled, depressed, and hurt Mary. Tremors prevented her from using a fork and knife.

She lived with chronic back pain and sciatica after a fall that fractured her back in three places. Mary relied on 24/7 care.

In May of 2014, Mary attended her granddaughter’s wedding in a wheelchair. Per her primary care physician, “All the guests were commenting on her deteriorating health and how they did not expect her to survive much longer.”

After spending two weeks in the Cleveland Clinic ICU, the doctors told Mary to get her affairs in order. All this left her depressed with thoughts of suicide.

In October 2014, Ambrose’s predecessor group treated Mary with a novel ADRC-based protocol, which sparked her Comeback to the Future. Seven years after that single treatment, Mary celebrated her 93rd birthday with friends.

She lived independently, her Parkinson’s symptoms were mild compared to her baseline, and her mood was upbeat. Mary walked on the treadmill and worked out at the gym four days per week. Her back pain and sciatica had long since resolved.

Living to 93 is one thing; it’s another to be active and enjoy life despite all odds.

Aging’s Dismal Future
Until cell therapy sparked Mary’s recovery, she shared a dismal future with over 100 million adults. Four out of ten adults live with two or more chronic diseases.

As we age, the situation becomes dire: The average senior sees seven doctors and takes seven meds per year.

Connecting the Dots
At the time of Mary’s treatment, stem cell researchers had not yet connected the common factors of age-related conditions with the cellular mechanisms that enabled Mary’s remarkable reversal of symptoms, function, and quality of life. The secret to going Back to the Future lies in that relationship.

Coming Back to the Future, we now understand that Mary’s ADRCs abided by the laws of nature. But how? Centuries-long research held the clue. And new-age science and technology unraveled the mystery. More on that later, first, let’s catch up with the past.

Back to Nature – Physiology, and Balance
Going Back to the Future requires going back to basics, starting with physiology. Physiology traces its roots to ancient India, Egypt, and Greece.

  • Hippocrates, the Father of Medicine, played a crucial role in introducing the Four Humors (bodily fluids). His fifth-century BC treatise, The Nature of Man, defined good health as the balance and mixture of the humors while their imbalance and separation caused disease.
  • Jean Fernel (1497-1558), a French physician, introduced the term “physiology,” from Ancient Greek, meaning “study of nature, origins.” In other words, physiology refers to the body’s natural processes, functions, and systems. He published his book The Natural Part of Medicine in 1542.
  • In the 1870s, Claude Bernard, a French physiologist, described how complex organisms must maintain balance in their internal environment, or “milieu intérieur,“to lead a “free and independent life” in the world beyond.
  • Fifty years later, physiologist Walter Cannon coined the term homeostasis, expanding on Hippocrates’, Fernel’s, and Bernard’s work. From the Greek words for “same” and “steady,” homeostasis refers to the physiologic balance necessary for survival.
  • In 1948, biologist Claude Shannon, Ph.D., wrote the Magna Carta of the Information Age, Information Theory. Here, Shannon bridged DNA signaling processes to digital communications. [2] His paper ignited the technology revolution. In other words, our iPhones, computers, and the Internet evolved from cellular crosstalk.
  • It took another six decades for Arnold Caplan, Ph.D., a stem cell researcher at Case Western University, to connect physiology, homeostasis, and Information Theory to stem cell biology.

Big Pharma’s Profitable Failure
In contrast, Big Pharma ignores these fundamentals in favor of drugs, many with risks than can outweigh the benefits. For example, Dr. Armon Neel Jr. cautions that ten drug classes can cause or contribute to memory loss, brain fog, and fatigue.

Conventional medicine adheres to Big Pharma’s “one drug, one disease” model. Here, doctors prescribe pharmaceuticals that suppress the primary factor causing a disease or a symptom. This approach has done little to improve patients” healthspan with age-related diseases. And it did not work for Mary either.

 In Mary’s case, she was taking Sinemet for tremors, Lyrica for pain, and Cortisone shots for sciatica – at a minimum. Drug companies make a lot of money from multiple drug prescriptions (polypharmacy) – but Mary’s health did not profit to the same degree, e.g., she talked of suicide, a known side-effect of both Lyrica and Sinemet.

Mary’s Comeback
As her daughter said 18 months after Mary’s treatment, “For her back, the results were incredible. She had two fractures in her lower lumbar. A lot of people never would have gotten out of bed, but she’s 87, and we call her the comeback kid. She’s up at the gym almost every day now with her trainer, who sometimes has to ask her to tone it down, so she doesn’t over-exert herself!”

“Beyond that, now she is walking very straight and isn’t shuffling her feet. Occasionally when she’s tired, she’ll veer off a little, but she’s not using a walker or a cane. She is doing really, really well, and a lot of this is due to the stem cell therapy.

Is Mary’s story a placebo effect? It all sounds too good to be true, but other Patient-Reported Outcomes demonstrate Mary’s benefits are not unique to her.

Bridging the Gap

  • In the mid-1960s, Martin Rodbell, Nobel Laureate for Physiology or Medicine, isolated a mixed population of regenerative cells in fat or adipose tissue called stromal vascular fraction (SVF). Stroma means connective tissue (fat). Fraction is the cellular fraction liberated from the outer lining of the vessels intermingled in the fat.
  • In 1991, Arnold Caplan, Ph.D., envisioned “the emergence of a new therapeutic paradigm, “Self-Cell Repair”. Dr. Caplan postulated that a person’s adult stem cells, which he named mesenchymal stem cells (MSCs), could be used to repair diseased tissues and organs.
  • Ten years later, UCLA researchers Patricia Zuk et al. discovered the most accessible, abundant, and potent source of MSCs: Adipose Tissue. Zuk’s group bridged the gap between the age-old science of physiology and the new-age medicine of ADRCs.
  • Ten years after Zuk’s lab discovery, Dr. Caplan renamed MSCs “medicinal signaling cells,” connecting physiology, homeostasis, DNA signaling, and stem cell biology.
  • ADRCs contain DNA in each cell’s nucleus. Thus, they adhere to Caplan’s Medicinal Signaling Cell framework.
  • In 2012, Dr. James Willerson and Dr. Emerson Perin from Texas Heart Institute published Buying New Soul. Here, they proposed adipose tissue as the best source of adult stem and regenerative cells – and connected Bradbury’s Back to the Future with ADRCs’ potency late in life. In other words, fatty tissue protects these cells from dreaded stem cell exhaustion.

Notably, over the past 22 years, investigators have published over 85,000 papers discussing adipose-derived stem cells (ADSCs). That is an average of 11 new publications per day. Most impressive, the publishing rate has accelerated to 36 papers per day, nearly four times the historical average.

A Golden Era of Cell-Assisted Aging?
Aging constitutes a sudden or general onset of multiple physiologic imbalances or multisystem dysregulation. Mary’s symptoms were a good example of this.

In 2006, Dr. William Langston, the Michael J. Fox Foundation’s first Chief Science Officer, published The Parkinson’s Complex: Parkinsonism Is Just the Tip of the Iceberg. [3] In short, Dr. Langston’s seminal paper stated there is more to PD than the loss of dopamine-producing neurons in the brain.

Instead, Parkinsonism involves multisystem breakdowns. Therefore, he stated, “Rather, we must deal with all aspects of the disease if we are to modify its progress in a way that truly enhances the lives of our patients over the long term.

Likewise, researchers connect negative systemic influences with heart failure, kidney disease, Alzheimer’s, diabetes, and so on.

Succinctly, as we age, our cells, tissues, organs, and systems lose harmony. [4] [5] [6]  Instead, multiple conductors direct the orchestra according to their respective interpretations of the score.[7] [8] [9] [10] [11]

In other words, our immune, vascular, nervous, and other systems give dissonant instructions to our cells, tissue, and organs. Simply put, multisystem disharmony is the overarching factor underlying Mary’s symptoms.  [12] [13] [14] [15] [16]

After her one-time treatment, Mary’s ADRCs restored physiologic harmony.

In scientific terms, her restorative cells secreted hundreds of healing, or trophic factors, that signaled the resident cells to resume playing according to her musical score.

Put another way, Dr. Caplan’s Medicinal Signaling Cell framework performed better than he hypothesized. The cellular cross talk between the MSCs and the resident cells restored multisystem homeostasis.

In the real world, Mary’s mood, energy, motor control, balance, and pain score remain improved for more than seven years.

Further, Mary’s outcome validated Dr. Langston’s 2006 hypothesis. Most important, Mary, her friends, and her family enjoyed her Comeback to the Future.

[1] Based on information provided by Mary, her primary care, family, and friends. Medical records are not available.

[2] Schneider T A brief review of molecular information theory Nano Commun Netw. 2010 September; 1(3): 173–180

[3] Langston J W The Parkinson’s Complex: Parkinsonism Is Just the Tip of the Iceberg Annals of Neurology Vol 59 No 4 April 2006

[4] Takuya Kishi Heart failure as an autonomic nervous system dysfunction Journal of Cardiology (2012) 59, 117—122

[5] Sági B et al The prognostic role of heart rate recovery after exercise and metabolic syndrome in IgA nephropathy BMC Nephrology (2021) 22:390

[6] McCaulley M and Grush K Alzheimer’s Disease: Exploring the Role of Inflammation and Implications for Treatment International Journal of Alzheimer’s Disease Volume 2015, Article ID 515248,

[7] Kelleher R, Soiza R Evidence of endothelial dysfunction in the development of Alzheimer’s disease: Is Alzheimer’s a vascular disorder? Am J Cardiovasc Dis 2013;3(4):197-226

[8] Dantzer R. Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa. Physiol Rev. 2018;98(1):477-504.

[9] Amiya E MD PHD et al The Relationship between Vascular Function and the Autonomic Nervous System Ann Vasc Dis Vol. 7, No. 2; 2014; pp 109–119 Online Month May 16, 2014

[10] Tracey K The inflammatory reflex Nature Vol 420 19/26 December 2002

[11] Simora N et al. The Role of the Immune System in Metabolic Health and Disease Cell Metabolism 25, March 7, 2017

[12] Kelleher R, Soiza R  Evidence of endothelial dysfunction in the development of Alzheimer’s disease: Is Alzheimer’s a vascular disorder? Am J Cardiovasc Dis 2013;3(4):197-226

[13] Dantzer R. Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa. Physiol Rev. 2018;98(1):477-504.

[14] Amiya E MD PHD et al The Relationship between Vascular Function and the Autonomic Nervous System Ann Vasc Dis Vol. 7, No. 2; 2014; pp 109–119 Online Month May 16, 2014

[15] Tracey K The inflammatory reflex Nature Vol 420 19/26 December 2002

[16] Simora N et al. The Role of the Immune System in Metabolic Health and Disease Cell Metabolism 25, March 7, 2017

AMBROSE Cell Therapy

Your Right to Try

Realistic Expectations and Optimizing Your Outcome

Realistic Expectations and Optimizing Your Outcome

Realistic Expectations and Optimizing Your Outcome

It remains obvious that lifestyle contributes to health or disease. Excessive work, being sedentary, smoking, substance abuse, a poor diet, unhealthy relationships, etc., are associated with poor health.

Therefore, patients who take responsibility for their overall health and outcome are more likely to super-respond to their cell therapy.

On the opposite side of the coin, ignoring the basics of health and wellness should mute your expectations. Your outcome will be better to the degree that you contribute to the repair process.

FAQs

When should I begin exercise?
You may start walking and light exercise within a week or two of your procedure, depending upon when you feel up to it.

Patients should begin exercising at 25% of their normal level at about four weeks out. You may increase that by 25% every two weeks. In other words, most patients take a little more than two months to return to playing golf, tennis, yoga or working out.

You should take your time before resuming sports known to stress the musculoskeletal system. Your body will tell you if you are doing too much too soon or can do more than the formula above.

The repair process takes time. Exercise helps it but rushing back into sports works against that process. The needed period varies from person to person. Patience remains a virtue.

When will I begin to experience benefits?
Every patient is unique; therefore, their path of improvement differs. Bearing that in mind, most patients experience notable benefits between four and six weeks.
Because ADRCs are regenerative and restorative, they continue to do their jobs for months and even years. Many patients say their rate of benefit accelerated over time.

What to expect when?
No two patients have responded the same, yet AMBROSE’s Patient-Reported Outcomes suggest a pattern:

  1. Patients feel an emotional lift. They express this as more energy, happier, equanimity, a sense of well-being, and mental clarity.
  2. Pain begins to subside, and function starts to improve.
  3. They become more active.

Is stem cell therapy a cure?
A cure implies one never experiences a sign or symptom of a disease again. This expectation is unrealistic. In contrast, Ambrose Cell Therapy aims to improve symptoms, function, and quality of life.

Who benefits the most?
Patients who adopt or continue common sense diet, exercise, and lifestyle practices benefit the most from cell therapy.
Notably, Ambrose can eliminate the requirement for extreme diets, excessive supplements, regular chiropractic adjustments, and so forth.
From a different angle, people who failed to respond to PT or other conservative modes of therapy before AMBROSE often do so after their treatment. Published studies support this potential benefit.

What causes a flare?
Levels of physical or psychological stress exceeding what an individual can tolerate fight with the healing process.

For example:

  • Some exercises aggravate back pain, e.g., crunches, the treadmill, and some stretches. It is different for everybody.
  • The same holds for shoulders, hips, knees, and so forth. You may find eliminating a particular exercise, dialing back the frequency or intensity, or improving your form resolves the flare.
  • Inactivity and overdoing exercise cause relapses or lack of response in the first place.
  • Dementia, Parkinson’s, MS, and other neurologic conditions lower tolerance for psychological and physical stress. Travel, work, large gatherings, and negativity may be too much for individuals living with these diseases. Thus, patients and their caregivers should not expect to travel, work, and socialize as they did before the onset of their condition. As symptoms subside, the goal is to return to activities with family and friends, sports, and work as appropriate for them.
  • Sometimes caregivers over-care for the family member. They bring them to multiple healthcare providers, restrict their diets, overdo nutritional supplements, and so on. Despite one’s best intentions, this approach adds stress. Instead, the best therapies are being with family and friends and doing enjoyable, relaxing activities.

Improving Cell Therapy Outcomes explains the cycle of stress in more detail.

In summary, listen to your body and manage your activities accordingly. As the body becomes healthier, you can do more. On the other side of the coin, if specific exercises cause pain or other symptoms, it is essential to identify the triggers and modify what you are doing.

AMBROSE Cell Therapy

Your Right to Try

Tony Robbin’s Life Force Stem Cell Discussion Review

Tony Robbin’s Life Force Stem Cell Discussion Review

Tony Robbin’s Life Force Stem Cell Discussion Review

“After so many years of agony from my spinal stenosis, now I was standing straight and strong without an ounce of pain in my back. It felt supple and free, better than it had in decades. You know that expression, I felt like a brand-new person? Without exaggeration, that new person was me. Six years later, my shoulder is still perfect, with full range of motion. I don’t baby it; to be honest[…]” Life Force Tony Robbins, Peter Diamandis MD, and Robert Hariri MD

Tony Robbins wrote Life Force so we could be the CEOs of our health. He brings stem cell therapy to the front of the stage with his “brand-new person” account of his stem cell treatment in Panama. He tells a larger-than-life story because, well, that is Tony.

As to the science, Tony relies on well-respected experts (with whom he invests) for his “facts.” However, his stem cell explanation suffers from what behavioral finance gurus call “cognitive bias” (A. Tversky and D. Kahneman 1972).

Why Our Review?
This review separates fact from bias and real-world outcomes from unrealistic expectations. Further, we reconstruct Tony’s inspiring yet ambiguous narrative into a clarifying before-during-and-after timeline.

We presume that Tony benefited from cell therapy. Stem cells are effective in treating the conditions from which he suffered. It is just hard to know how much, for how long, and why. In Chapter 18, Tony dropped a subtle bomb on his born-again in Panama story: He did another treatment to handle the “challenges” related to the Panama treatment discussed in Chapter 2. More on that in a moment, first this review’s purpose.

Realistic Expectations
Our review aims to set realistic expectations and empower patients to make an informed choice regarding stem cell therapy. As Warren Buffett once counseled a CEO, “The way to have a happy marriage is to marry someone with low expectations.” Better said, it is best to set expectations cell therapy can meet or beat. Claims of immediate miracle cures do not help anyone.

Unfortunately, Tony’s too incredible to be believed stem cell miracle – in less than 72 hours- may set people up for disappointment. Stem cell therapy doesn’t take effect like a pain killer – at least for most people.

To be clear, Tony, Trish, and many other AMBROSE Cell Therapy patients report sustained benefits from a single treatment. But they improved for months or even years before they plateaued.

With all that said, we applaud Tony’s stem cell advocacy. He gives hope to 10’s of millions of people living with debilitating conditions unsatisfied with conventional and integrative medicine.

Back to Tony’s Story
Tony’s story begins: “I have to admit, I was acting more like a 14-year-old at the time, tearing down a mountain in Sun Valley, Idaho, on my snowboard. It went horribly wrong, and I fell with a bone-rattling force that annihilated my shoulder.

It turned out that I’d torn my rotator cuff, the set of tendons and muscles connecting the upper arm to the shoulder. Over the years, I’d dealt with lots of pain. This hurt so brutally that I didn’t know what to do with myself. On a scale of one to ten, I’d award this pain a score of 9.9!    My nerves were on fire. Deep breaths even hurt. Over the next two nights, I slept a grand total of two hours.” Ouch.

The melodrama continued. More on that in a moment, first let us fact-check Tony’s science presentation.

Fat Fact-checking
The cognitive bias begins when Tony credits Dr. Bob Hariri with discovering stem cells in placentas doomed for the dumpster. Then Bob tosses “autologous fat-stem cells” into the medical waste in two ways. He fails to mention:

1. Zuk et al.’s 1999 discovery in a UCLA lab that adipose tissue is the most accessible, abundant, and potent source of mesenchymal stem cells (MSCs), and

2. Adipose tissue contains a mixed population of stem cells and other regenerative cells. Researchers call these autologous Adipose-Derived Regenerative Cells or ADRCs.

He reasons that stem cells from bone marrow, skin, or adipose tissue decline in number and potency as we age. Hariri calls this process stem cell exhaustion. Thus, he argues cultured allogeneic or donor placental-derived MSCs (PD-MSCs) are pristine. Umbilical-cord-derived MSCs (UC-MSCs) are next best. The hypothesis is making sense – so far.

But just because it’s logical doesn’t mean it’s true. James Willerson, MD, Ph.D., and Emerson Perin, MD, Ph.D., from Texas Heart Institute, contradicted Bob’s argument in Buying New Soul (2012).[1]

Adipose tissue seems to be a promising source of stem cells…The resiliency of adipose tissue is evidenced by patients’ ability to gain weight easily even in the presence of multiple comorbidities known to inhibit stem cell function. It may be that certain tissues are less exposed to the detrimental effects of disease and aging.”

Notably, investigators have published over 85,000 papers discussing adipose-derived stem cells (ADSCs). That is an average of 11 new publications per day over the past 22 years. The publishing rate has accelerated to 36 per day, nearly four times the historical average.

A PubMed search finds less than half as many publications on Placenta-derived stem cells (PDSCs).

Jack Nicklaus’ Stem Cell Therapy Hole-in-One
After Bob gave fat a lousy score, Tony recounted meeting Jack Nicklaus at the Vatican Stem Cell Summit. Here, Jack told the audience about his stem cell therapy hole-in-one. Stem cells “helped me go from not being able to stand for longer than 10 minutes, to playing golf and hitting the tennis ball again without pain. They will dramatically enhance your life!”

Apparently, Tony didn’t know prof Dr. Eckhard Alt treated Jack’s back with ADRCs. The your-fat-stem cells-are-too-old theory missed the cut here: Jack was in his late 70s when he opted to go to Germany for autologous ADRCs.

Note, Jack said “helped me” – stem cells are the fertilizer – physical therapy, appropriate exercise, and a healthy lifestyle are the gardeners that restore health.

Finally, our groups in the Bahamas and the U.S. have treated ~400 patients with ADRCs.

We counted every patient’s total nucleated cell (TNCs) with the NucleoCounter. A TNC contains DNA, which makes the cell active. Red blood cells do not have a nucleus and thus have no therapeutic effect. A review of the stats proves Dr. Willerson’s point: ADRCs’ yield, viability, and, most important, outcomes do not suffer from age.

Two over-70 patients with multiple morbidities hold the male and female records for highest yields and viability.

  • Nancy, a skinny long-term smoker with COPD, arthritis, and dermatitis, and
  • Bob, an obese man with polyarthritis, a rare neurologic condition, migraine headaches, and frailty.

On the other side of the coin, a 15-year-old spinal cord injury patient’s yield was right up there with Bob. Six months post-cell therapy and more than one year after his catastrophic injury, the young man regained bilateral motor control of his hip flexors and quads. Standard of Care SCI patients plateau at about 12-months – remarkably, this young man’s path is accelerating.

Most profound, our patients with multiple chronic conditions, including diabetes, heart, kidney, and autoimmune diseases – including obese patients – report high patient satisfaction.

Back to Tony’s story
Three specialists advised surgery. Then one injected PRP but must have hit a nerve as Tony’s arm went limp while performing. Next, a doctor recommended Pulsed Electro-Magnetic Field Therapy (PEMF). PEMF helped: His pain score reduced to 4.5. Tony continued PEMF until he arrived in Panama. Presumably, his pretreatment score pain was lower still.

The Panama clinic gave him three IV shots of umbilical cord-derived mesenchymal stem cells (UB-MSCs) over three days. On the first day, a doctor injected stem cells into his shoulder – but not his back.

On day two, Tony had an adverse event: “…I had what’s often called a “cytokine response.” I felt chills and shaking, but I wasn’t scared. They told me it was normal: “Your body’s healing, just get some rest.”

At the risk of offending Tony or the clinic staff: A cytokine response is an abnormal reaction.    The body’s immune system recognized the donor stem cells as foreign (or contaminated). These reactions do not occur with autologous ADRCs.

By the way, we respect Neil Riordan, Ph.D., CEO of the Stem Cell Clinic of Panama. He co-authored three early, highly cited papers on stromal vascular fraction (the generic term for ADRCs).

Recent research clarifies that donor stem cells are “immune-evasive, not immune-privileged,” counter to the proponents of allogeneic cell therapy.[2] [3] Simply put, the Panamanian UB-MSCs and Tony’s immune system were not a perfect match. Married couples fight from time to time but can still be happy. Perhaps, that was the case with Panama clinic’s Golden Cells. They had a little spat and got on with it.

Thankfully, Tony says the shaking lasted 20 minutes. He did not allow how long the chills lasted or if he caught a fever. Published clinical trials report allogeneic MSC infusions often cause transient fevers. This side-effect is mild, particularly compared to the risks of surgeries, drugs, and devices.

Miraculously, 15 years of back pain and shoulder pain were gone for good on the third day, Tony stated. He does not specify if the injection doctor was board-certified in pain management. Of if the shoulder injections were done under ultrasound? As one reads on, the story gets confusing.

The stem cells took effect on day three – but we don’t know for how long or how much.

And here is the rub: The continuing story makes it hard to attribute the awe-inspiring, new-life proclamation to life force UB-MSCs alone. That is ok – if Tony’s fans understand that. First, his shoulder may not have been in that much pain, thanks to the PEMF and conventional care, i.e., ice, PT, and rest. And resting during the three-day protocol may have decompressed his spine.

Plus, he indulges in multiple biohacks per day for pain and inflammation.

Here is the point: Unrealistic expectations lead to disappointed patients. But they are thrilled when stem cell therapy helps them live a better life.

As Tony’s research, therapy, and investment journey twists and turns like Jack’s back did when he played the PGA tour, Tony accesses innumerable tools for his health:

  • Cryo-therapy,
  • Counter-strain physical therapy,
  • Laser therapy
  • Hyperbaric oxygen therapy,
  • PEMF therapy
  • Egoscue exercises,
  • Supplements,
  • Sauna,
  • Exosomes,
  • Stem cells, etc.

Last but not least, his story double-bogeyed with exosomes, nano-sized sacs of growth factors secreted from MSCs. “I personally used exosomes along with stem cells to address a variety of challenges I experienced as a result of the work I had done on my shoulder that I told you about in Chapter 2,”

What? Tony said Panama stem cells resolved those challenges on Day Three.

For reasons best known to biohackers and God, there is a growing misbelief that exosomes are more effective than MSCs. That science discussion is beyond the scope of this review. Suffice to say, MSCs release exosomes, growth factors, hormones, and anti-inflammatory cytokines in a single dose.

Significantly, ADRCs secrete hundreds more healing or trophic factors than cultured MSCs do alone.[4]  All these attributes place clinical-grade ADRCs at the top of the leader board.

However, that doesn’t mean PD-MSCs, UB-MSCs, and BM-MSCs aren’t effective. They can shoot par. But safety and effectiveness depend on complying with Good Lab Practices (GLPs), the culturing method, and other technical specifications. Pew Trusts exposed contamination-related adverse events when doctors treat patients with cheap and cheerful stem cell products.

AMBROSE’s use of the Celution™ cell processing system and compliance with the Federal Right to Try Act of 2017 underpins our pristine cell-related safety record.

Tony is a Humanitarian. He has inspired millions of people to live better lives and means Life Force to do the same thing. His 1100-page 17-hour listen does so.

However, he diluted his sincere intentions with cognitive bias, contradictory evidence, conflicts of interest, and hyperbole. Our forensic review of the stem cell commentary suggests other information in the book suffered the same fate.

Life Force is a best-seller.

[1] J. Willerson and E. Perin Buying New Soul J Am Coll Cardiol. 2012;60(21):2250-2251

[2] Berglund et al. Immunoprivileged no more: measuring the immunogenicity of allogeneic adult mesenchymal stem cells Stem Cell Research & Therapy (2017) 8:288

[3] Akrum et al Mesenchymal stem cells: immune evasive, not immune privileged Nat Biotechnol. 2014 March ;32(3):252–260

[4] Hirosi Y et al. Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/ stem cells in the same individuals

AMBROSE Cell Therapy

Your Right to Try