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Celution™ System Peer-Reviewed Papers

Cytori Citations

Akita, S., et al. “Autologous Adipose-Derived Regenerative Cells Are Effective for Chronic Intractable Radiation Injuries.” Radiation Protection Dosimetry, vol. 151, no. 4, 2012, pp. 656–660.,

Andjelkov, Katarina, and Zoran Maricic. “Posterior Fourchette Fissure Resolution after Injection of Autologous Adipose-Derived Regenerative Cells.” Obstetrics & Gynecology, vol. 129, no. 3, 2017, pp. 497–499.,

Arkoulis, Nikolaos, et al. “Stem Cell Enriched Dermal Substitutes for the Treatment of Late Burn Contractures in Patients with Major Burns.” Burns, vol. 44, no. 3, 2018, pp. 724–726.,

Aronowitz, Joel A., and Joshua D.I. Ellenhorn. “Adipose Stromal Vascular Fraction Isolation: A Head-to-Head Comparison of Four Commercial Cell Separation Systems.” Plastic and Reconstructive Surgery, vol. 132, 2013, p. 48.,

C. Calabrese, A. Kothari, S. Badylak, G. Di Taranto, M. Marcasciano, et al. Oncological safety of stromal vascular fraction enriched fat grafting in two-stage breast reconstruction after nipple sparing mastectomy: long-term results of a prospective study Eur Rev Med Pharmacol Sci. 2018 Aug;22(15):4768-4777. doi: 10.26355/eurrev_201808_15610. PMID: 30070312.

Calcagni, Maurizio, et al. “The Novel Treatment of SVF-Enriched Fat Grafting for Painful End-Neuromas of Superficial Radial Nerve.” Microsurgery, vol. 38, no. 3, 2016, pp. 264–269.,

Cervelli, Valerio, et al. “Application of Enhanced Stromal Vascular Fraction and Fat Grafting Mixed with PRP in Post-Traumatic Lower Extremity Ulcers.” Stem Cell Research, vol. 6, no. 2, 2011, pp. 103–111.,

Choi, Jae Young, et al. “Adipose-Derived Regenerative Cell Injection Therapy for Postprostatectomy Incontinence: A Phase I Clinical Study.” Yonsei Medical Journal, vol. 57, no. 5, 2016, p. 1152.,

Daumas, A., et al. “Long-Term Follow-up after Autologous Adipose-Derived Stromal Vascular Fraction Injection into Fingers in Systemic Sclerosis Patients.” Current Research in Translational Medicine, vol. 65, no. 1, 2017, pp. 40–43.,

F. Yotsumoto et al. Adipose tissue-derived regenerative cells improve implantation of fertilized eggs in thin endometrium Regen.Med. (2020) 15(7), 1891–1904


Foubert, Philippe, et al. “Autologous Adipose-Derived Regenerative Cell Therapy Modulates Development of Hypertrophic Scarring in a Red Duroc Porcine Model.” Stem Cell Research & Therapy, vol. 8, no. 1, 2017,

Foubert, Philippe, et al. “Preclinical Assessment of Safety and Efficacy of Intravenous Delivery of Autologous Adipose-Derived Regenerative Cells (ADRCs) in the Treatment of Severe Thermal Burns Using a Porcine Model.” Burns, vol. 44, no. 6, 2018, pp. 1531–1542.,

François, P et al. Inter-center comparison of good manufacturing practices-compliant stromal vascular fraction and proposal for release acceptance criteria: a review of 364 productions. Stem Cell Res Ther 12, 373 (2021).

François, Pauline, et al. “Development and Validation of a Fully GMP-Compliant Process for Manufacturing Stromal Vascular Fraction: A Cost-Effective Alternative to Automated Methods.” Cells, vol. 9, no. 10, 2020, p. 2158.,

Fraser, John K., et al. “The Celution®System: Automated Processing of Adipose-Derived Regenerative Cells in a Functionally Closed System.” Advances in Wound Care, vol. 3, no. 1, 2014, pp. 38–45.,

Gentile, Pietro, et al. “Breast Reconstruction with Enhanced Stromal Vascular Fraction Fat Grafting.” Plastic and Reconstructive Surgery – Global Open, vol. 3, no. 6, 2015,

Gentile, Pietro, et al. “Characteristics and Potentiality of Human Adipose-Derived Stem Cells (Hascs) Obtained from Enzymatic Digestion of Fat Graft.” Cells, vol. 8, no. 3, 2019, p. 282.,


Granel, Brigitte, et al. “Safety, Tolerability and Potential Efficacy of Injection of Autologous Adipose-Derived Stromal Vascular Fraction in the Fingers of Patients with Systemic Sclerosis: An Open-Label Phase I Trial.” Annals of the Rheumatic Diseases, vol. 74, no. 12, 2014, pp. 2175–2182.,

Guillaume-Jugnot, Perrine, et al. “Autologous Adipose-Derived Stromal Vascular Fraction in Patients with Systemic Sclerosis: 12-Month Follow-Up.” Rheumatology, vol. 55, no. 2, 2015, pp. 301–306.,

Guillo, L., Grimaud, F., Houser, F. et al. Three-year outcome of local injection of autologous stromal vascular fraction cells and microfat in refractory perianal fistulas of Crohn’s disease. Stem Cell Res Ther 13, 67 (2022).

Haahr, Martha Kirstine, et al. “A 12-Month Follow-up after a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial.” Urology, vol. 121, 2018,

Hao, Changning, et al. “Therapeutic Angiogenesis by Autologous Adipose-Derived Regenerative Cells: Comparison with Bone Marrow Mononuclear Cells.” American Journal of Physiology-Heart and Circulatory Physiology, vol. 307, no. 6, 2014,

Saxer, F et al. Implantation of Stromal Vascular Fraction Progenitors at Bone Fracture Sites: From a Rat Model to a First-in-Man Study. Stem Cells. 2016 Dec;34(12):2956-2966. doi: 10.1002/stem.2478. Epub 2016 Sep 16. PMID: 27538760.

Herold, C, et al. “Supplementation of Fat Grafts with Adipose-Derived Regenerative Cells in Reconstructive Surgery.” GMS German Plastic, Reconstructive and Aesthetic Surgery, vol. 2, no. ISSN 2 1 93-7052, 2012.

Hirose, Yujiro, et al. “Comparison of Trophic Factors Secreted from Human Adipose-Derived Stromal Vascular Fraction with Those from Adipose-Derived Stromal/Stem Cells in the Same Individuals.” Cytotherapy, vol. 20, no. 4, 2018, pp. 589–591.,

Itose, Masakatsu, et al. “Knee meniscus regeneration using autogenous injection of uncultured adipose tissue-derived regenerative cells.” Regenerative Therapy 21 (2022): 398-405.

Jørgensen, Mads Gustaf, et al. “Adipose-Derived Regenerative Cells and Lipotransfer in Alleviating Breast Cancer-Related Lymphedema: An Open-Label Phase I Trial with 4 Years of Follow-Up.” Stem Cells Translational Medicine, vol. 10, no. 6, 2021, pp. 844–854.,

Kaita, Yasuhiko, et al. “Sufficient Therapeutic Effect of Cryopreserved Frozen Adipose-Derived Regenerative Cells on Burn Wounds.” Regenerative Therapy, vol. 10, 2019, pp. 92–103.,

Karaaltin, Mehmet Veli, et al. “Treatment of ‘En Coup De Sabre’ Deformity with Adipose-Derived Regenerative Cell–Enriched Fat Graft.” Journal of Craniofacial Surgery, vol. 23, no. 2, 2012,

Katagiri, Takeshi, et al. “Therapeutic Angiogenesis Using Autologous Adipose-Derived Regenerative Cells in Patients with Critical Limb Ischaemia in Japan: A Clinical Pilot Study.” Scientific Reports, vol. 10, no. 1, 2020,

Konstanty-Kalandyk J et al. Functional Recovery after Intramyocardial Injection of Adipose-Derived Stromal Cells Assessed by Cardiac Magnetic Resonance Imaging. Stem Cells Int. 2021 Apr 22;2021:5556800.

Kuzma-Kozakiewicz, Magdalena, et al. “Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools.” Stem Cells International, vol. 2018, 2018, pp. 1–16.,

Lasso, José M., et al. “Injection Laryngoplasty Using Autologous Fat Enriched with Adipose-Derived Regenerative Stem Cells: A Safe Therapeutic Option for the Functional Reconstruction of the Glottal Gap after Unilateral Vocal Fold Paralysis.” Stem Cells International, vol. 2018, 2018, pp. 1–15.,

Lathan, Rashida, et al. “Ischemic and Perfused Kidney Treated with Non-Cultured Adipose-Derived Regenerative Cells Increase the Immune and Regulatory Transcriptome.” Transplantation, vol. 104, no. S3, 2020,

Maruya, Yasuhiro, et al. “Autologous Adipose-Derived Stem Cell Sheets Enhance the Strength of Intestinal Anastomosis.” Regenerative Therapy, vol. 7, 2017, pp. 24–33.,

Mattei, Alexia, et al. “Autologous Adipose-Derived Stromal Vascular Fraction and Scarred Vocal Folds: First Clinical Case Report.” Stem Cell Research & Therapy, vol. 9, no. 1, 2018,

Mazini, Loubna, et al. “Overview of Current Adipose-Derived Stem Cell (Adscs) Processing Involved in Therapeutic Advancements: Flow Chart and Regulation Updates before and after COVID-19.” Stem Cell Research & Therapy, vol. 12, no. 1, 2021,

Onoi Y et al. Clinical use of autologous adipose-derived stromal vascular fraction cell injections for hip osteoarthritis. Regen Ther. 2023 Jun 15;24:94-102. 

Perin, Emerson C., and James T. Willerson. “Buying New Soul.” Journal of the American College of Cardiology, vol. 60, no. 21, 2012, pp. 2250–2251.,

Prins, Henk-Jan, et al. “Bone Regeneration Using the Freshly Isolated Autologous Stromal Vascular Fraction of Adipose Tissue in Combination with Calcium Phosphate Ceramics.” Stem Cells Translational Medicine, vol. 5, no. 10, 2016, pp. 1362–1374.,

Sasaki, Gordon H. “The Safety and Efficacy of Cell-Assisted Fat Grafting to Traditional Fat Grafting in the Anterior Mid-Face: An Indirect Assessment by 3D Imaging.” Aesthetic Plastic Surgery, vol. 39, no. 6, 2015, pp. 833–846.,

Saxer, Franziska, et al. “Implantation of Stromal Vascular Fraction Progenitors at Bone Fracture Sites: From a Rat Model to a First-in-Man Study.” Stem Cells, vol. 34, no. 12, 2016, pp. 2956–2966.,

Shimizu, Shinobu, et al. “Design of a Single-Arm Clinical Trial of Regenerative Therapy by Periurethral Injection of Adipose-Derived Regenerative Cells for Male Stress Urinary Incontinence in Japan: The ADRESU Study Protocol.” BMC Urology, vol. 17, no. 1, 2017,

Shimizu, Yuuki, et al. “Adipose-Derived Regenerative Cells for Cardiovascular Regeneration – A Novel Therapy for the Cardiac Conduction System –.” Circulation Journal, vol. 79, no. 12, 2015, pp. 2555–2556.,

Shimizu, Yuuki, et al. “Rationale and Design of Therapeutic Angiogenesis by Cell Transplantation Using Adipose-Derived Regenerative Cells in Patients with Critical Limb Ischemia ― Tact-ADRC Multicenter Trial ―.” Circulation Reports, vol. 2, no. 9, 2020, pp. 531–535.,

Shimizu, Yuuki, et al. “Therapeutic Angiogenesis for Patients with No-Option Critical Limb Ischemia by Adipose-Derived Regenerative Cells: Tact-ADRC Multicenter Trial.” Angiogenesis, vol. 25, no. 4, 2022, pp. 535–546.,

Shimizu, Yuuki, et al. “Therapeutic Lymphangiogenesis with Implantation of Adipose‐Derived Regenerative Cells.” Journal of the American Heart Association, vol. 1, no. 4, 2012,

Suzuki, Junya, et al. “No Influence on Tumor Growth by Intramuscular Injection of Adipose-Derived Regenerative Cells: Safety Evaluation of Therapeutic Angiogenesis with Cell Therapy.” American Journal of Physiology-Heart and Circulatory Physiology, vol. 320, no. 1, 2021,

Szczepanik, Elzbieta, et al. “Intrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy.” Stem Cells International, vol. 2020, 2020, pp. 1–16.,

Tsekouras, Anastasios, et al. “Adipose-Derived Stem Cells for Breast Reconstruction after Breast Surgery – Preliminary Results.” Case Reports in Plastic Surgery and Hand Surgery, vol. 4, no. 1, 2017, pp. 35–41.,

Tsubosaka, Masanori, et al. “The Influence of Adipose-Derived Stromal Vascular Fraction Cells on the Treatment of Knee Osteoarthritis.” BMC Musculoskeletal Disorders, vol. 21, no. 207, 2020,

Yamaguchi, Shukuro, et al. “Adipose-Derived Regenerative Cells as a Promising Therapy for Cardiovascular Diseases: an Overview.” Nagoya J. Med. Sci, vol. 84, 2022, pp. 208–215.

Yoshimura, Kotaro, et al. “Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells.” Aesthetic Plastic Surgery, vol. 44, no. 4, 2020, pp. 1258–1265.,

Yoshimura, Kotaro. “Cell-Assisted Lipotransfer and Therapeutic Use of Adipose Stem Cells Thereafter.” Aesthetic Plastic Surgery, vol. 44, no. 4, 2020, pp. 1266–1267.,

Zuk, Patricia A., et al. “Human Adipose Tissue Is a Source of Multipotent Stem Cells.” Molecular Biology of the Cell, vol. 13, no. 12, 2002, pp. 4279–4295.,

Akita, Sadanori, et al. “Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury.” Stem Cells International, vol. 2010, 2010, pp. 1–8., doi:10.4061/2010/532704.

Albersen, Maarten, and Trinity J. Bivalacqua. “Regenerative Medicine for Erectile Dysfunction Following Radical Prostatectomy: Are We Ready?” EBioMedicine, vol. 5, 2016, pp. 28–29., doi:10.1016/j.ebiom.2016.02.033.

Ashjian, Peter H., et al. “In Vitro Differentiation of Human Processed Lipoaspirate Cells into Early Neural Progenitors.” Plastic and Reconstructive Surgery, vol. 111, no. 6, 2003, pp. 1922–1931., doi:10.1097/01.prs.0000055043.62589.05.

Borowski, David W., et al. “Adipose Tissue–Derived Regenerative Cell–Enhanced Lipofilling for Treatment of Cryptoglandular Fistulae-in-Ano.” Surgical Innovation, vol. 22, no. 6, 2015, pp. 593–600., doi:10.1177/1553350615572656.

Foubert, Philippe, et al. “Adipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods.” Advances in Wound Care, vol. 5, no. 7, 2016, pp. 288–298., doi:10.1089/wound.2015.0672.

Foubert, Philippe, et al. “Uncultured Adipose-Derived Regenerative Cells (Adrcs) Seeded in Collagen Scaffold Improves Dermal Regeneration, Enhancing Early Vascularization and Structural Organization Following Thermal Burns.” Burns, vol. 41, no. 7, 2015, pp. 1504–1516., doi:10.1016/j.burns.2015.05.004.

Fraser, John K, et al. “Plasticity of Human Adipose Stem Cells toward Endothelial Cells and Cardiomyocytes.” Nature Clinical Practice Cardiovascular Medicine, vol. 3, no. S1, 2006, doi:10.1038/ncpcardio0444.

Fraser, John K., et al. “Fat Tissue: An Underappreciated Source of Stem Cells for Biotechnology.” Trends in Biotechnology, vol. 24, no. 4, 2006, pp. 150–154., doi:10.1016/j.tibtech.2006.01.010.

Ganey, Timothy, et al. “Intervertebral Disc Repair Using Adipose Tissue-Derived Stem and Regenerative Cells.” Spine, vol. 34, no. 21, 2009, pp. 2297–2304., doi:10.1097/brs.0b013e3181a54157.

Gentile, Pietro, et al. “A Comparative Translational Study: The Combined Use of Enhanced Stromal Vascular Fraction and Platelet-Rich Plasma Improves Fat Grafting Maintenance in Breast Reconstruction.” Stem Cells Translational Medicine, vol. 1, no. 4, 2012, pp. 341–351., doi:10.5966/sctm.2011-0065.

Haahr, Martha Kirstine, et al. “Safety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial.” EBioMedicine, vol. 5, 2016, pp. 204–210., doi:10.1016/j.ebiom.2016.01.024.

Henry, Timothy D., et al. “The Athena Trials: Autologous Adipose-Derived Regenerative Cells for Refractory Chronic Myocardial Ischemia with Left Ventricular Dysfunction.” Catheterization and Cardiovascular Interventions, vol. 89, no. 2, 2016, pp. 169–177., doi:10.1002/ccd.26601.

Hirose, Yujiro et al. Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals Cytotherapy, Volume 20, Issue 4, 589 – 591

Houtgraaf, Jaco H., et al. “First Experience in Humans Using Adipose Tissue–Derived Regenerative Cells in the Treatment of Patients with St-Segment Elevation Myocardial Infarction.” Journal of the American College of Cardiology, vol. 59, no. 5, 2012, pp. 539–540., doi:10.1016/j.jacc.2011.09.065.

Iddins, C.J., et al. “Case Report: INDUSTRIAL X-RAY INJURY TREATED WITH NON-CULTURED AUTOLOGOUS ADIPOSE-DERIVED STROMALVASCULAR FRACTION (SVF).” Health Physics, vol. 111, no. 2, 2016, pp. 112–116., doi:10.1097/hp.0000000000000483.

Kakudo, Natsuko, et al. “Adipose-Derived Regenerative Cell (ADRC)-Enriched Fat Grafting: Optimal Cell Concentration and Effects on Grafted Fat Characteristics.” Journal of Translational Medicine, vol. 11, no. 1, 2013, p. 254., doi:10.1186/1479-5876-11-254.

Karaaltin, M, and S Baghaki. “Adipose Derived Regenerative Cell Therapy f or Treating a Diabetic Wound: A Case Report.”

Kesten, S, and J Fraser. “Autologous Adipose Derived Regenerative Cells: A Platform for Therapeutic Applications.” Surgical Technology International XXIX.

Kondo, Kazuhisa, et al. “Implantation of Adipose-Derived Regenerative Cells Enhances Ischemia-Induced Angiogenesis.” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 29, no. 1, 2009, pp. 61–66., doi:10.1161/atvbaha.108.166496.

Lin, K., et al. “Characterization of Adipose Tissue-Derived Cells Isolated with the Celution™ System.” Cytotherapy, vol. 10, no. 4, 2008, pp. 417–426., doi:10.1080/14653240801982979.

Marino, G, et al. “Therapy with Autologous Adipose-Derived Rigenerative Cells for the Care of Chronic Ulcer of Lower Limbs.” Seconda Università Degli Studi Di Napoli, 2012.

Marino, Gerardo, et al. “Therapy with Autologous Adipose-Derived Regenerative Cells for the Care of Chronic Ulcer of Lower Limbs in Patients with Peripheral Arterial Disease.” Journal of Surgical Research, vol. 185, no. 1, 2013, pp. 36–44., doi:10.1016/j.jss.2013.05.024.

Nordberg, Rachel C., and Elizabeth G. Loboa. “Our Fat Future: Translating Adipose Stem Cell Therapy.” Stem Cells Translational Medicine, vol. 4, no. 9, 2015, pp. 974–979., doi:10.5966/sctm.2015-0071.

“P406. Adipose Derived Regenerative Cells Injection as a Novel Method of Enterovesical Fistula Treatment in Crohn’s Disease: A Case Report.” Journal of Crohn’s and Colitis, vol. 9, no. suppl 1, 2015, doi:10.1093/ecco-jcc/jju027.525.

Perez-Meza, David, et al. “Hair Follicle Growth by Stromal Vascular Fraction-Enhanced Adipose Transplantation in Baldness.” Stem Cells and Cloning: Advances and Applications, Volume 10, 2017, pp. 1–10., doi:10.2147/sccaa.s131431.

Sakai, Yoshio, et al. “Phase I Clinical Study of Liver Regenerative Therapy for Cirrhosis by Intrahepatic Arterial Infusion of Freshly Isolated Autologous Adipose Tissue-Derived Stromal/Stem (Regenerative) Cell.” Regenerative Therapy, vol. 6, 2017, pp. 52–64., doi:10.1016/j.reth.2016.12.001.

Sridhar, P, et al. “Adipose-Derived Regenerative Cells for the Treatment of Patients with Non-Revascularisable Ischaemic Cardiomyopathy – the Precise Trial.” Interventional Cardiology Review, vol. 7, no. 2, 2012, p. 77., doi:10.15420/icr.2012.7.2.77.

Strem, B, et al. “Multipotential Differentiation of Adipose Tissue-Derived Stem Cells.” Keio J Med, 2005.

Suganuma, Seigo, et al. “Uncultured Adipose-Derived Regenerative Cells Promote Peripheral Nerve Regeneration.” Journal of Orthopaedic Science, vol. 18, no. 1, 2013, pp. 145–151., doi:10.1007/s00776-012-0306-9.

Tiryaki, Tunc, et al. “Staged Stem Cell-Enriched Tissue (Set) Injections for Soft Tissue Augmentation in Hostile Recipient Areas: A Preliminary Report.” Aesthetic Plastic Surgery, vol. 35, no. 6, 2011, pp. 965–971., doi:10.1007/s00266-011-9716-x.

Toyserkani, Navid Mohamadpour, et al. “Cell-Assisted Lipotransfer Using Autologous Adipose-Derived Stromal Cells for Alleviation of Breast Cancer-Related Lymphedema.” Stem Cells Translational Medicine, vol. 5, no. 7, 2016, pp. 857–859., doi:10.5966/sctm.2015-0357.

Toyserkani, Navid Mohamadpour, et al. “Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.” Stem Cells Translational Medicine, vol. 6, no. 8, 2017, pp. 1666–1672., doi:10.1002/sctm.17-0037.

Wein, Alan J. “Re: Regenerative Treatment of Male Stress Urinary Incontinence by Periurethral Injection of Autologous Adipose-Derived Regenerative Cells: 1-Year Outcomes in 11 Patients.” Journal of Urology, vol. 195, no. 2, 2016, pp. 420–420., doi:10.1016/j.juro.2015.10.113.

Yokota, Naomasa, et al. “Clinical Results Following Intra-Articular Injection of Adipose-Derived Stromal Vascular Fraction Cells in Patients with Osteoarthritis of the Knee.” Regenerative Therapy, vol. 6, 2017, pp. 108–112., doi:10.1016/j.reth.2017.04.002.

Yoshimoto, H, et al. “Efficacy of Patients’ Own Adipose-Derived Regenerative Cells for Chronic Intractable Radiation Injuries.” Journal of Wound Technology, Oct. 2010.

YOSHIMURA, KOTARO, et al. “Cell-Assisted Lipotransfer for Facial Lipoatrophy: Efficacy of Clinical Use of Adipose-Derived Stem Cells.” Dermatologic Surgery, vol. 34, no. 9, 2008, pp. 1178–1185., doi:10.1111/j.1524-4725.2008.34256.x.

Zuk, Patricia A., et al. “Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies.” Tissue Engineering, vol. 7, no. 2, 2001, pp. 211–228., doi:10.1089/107632701300062859.

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