Tony Robbin’s Life Force Stem Cell Discussion Review

Tony Robbin’s Life Force Stem Cell Discussion Review

Tony Robbin’s Life Force Stem Cell Discussion Review

“After so many years of agony from my spinal stenosis, now I was standing straight and strong without an ounce of pain in my back. It felt supple and free, better than it had in decades. You know that expression, I felt like a brand-new person? Without exaggeration, that new person was me. Six years later, my shoulder is still perfect, with full range of motion. I don’t baby it; to be honest[…]” Life Force Tony Robbins, Peter Diamandis MD, and Robert Hariri MD

Tony Robbins wrote Life Force so we could be the CEOs of our health. He brings stem cell therapy to the front of the stage with his “brand-new person” account of his stem cell treatment in Panama. He tells a larger-than-life story because, well, that is Tony.

As to the science, Tony relies on well-respected experts (with whom he invests) for his “facts.” However, his stem cell explanation suffers from what behavioral finance gurus call “cognitive bias” (A. Tversky and D. Kahneman 1972).

Why Our Review?
This review separates fact from bias and real-world outcomes from unrealistic expectations. Further, we reconstruct Tony’s inspiring yet ambiguous narrative into a clarifying before-during-and-after timeline.

We presume that Tony benefited from cell therapy. Stem cells are effective in treating the conditions from which he suffered. It is just hard to know how much, for how long, and why. In Chapter 18, Tony dropped a subtle bomb on his born-again in Panama story: He did another treatment to handle the “challenges” related to the Panama treatment discussed in Chapter 2. More on that in a moment, first this review’s purpose.

Realistic Expectations
Our review aims to set realistic expectations and empower patients to make an informed choice regarding stem cell therapy. As Warren Buffett once counseled a CEO, “The way to have a happy marriage is to marry someone with low expectations.” Better said, it is best to set expectations cell therapy can meet or beat. Claims of immediate miracle cures do not help anyone.

Unfortunately, Tony’s too incredible to be believed stem cell miracle – in less than 72 hours- may set people up for disappointment. Stem cell therapy doesn’t take effect like a pain killer – at least for most people.

To be clear, Tony, Trish, and many other AMBROSE Cell Therapy patients report sustained benefits from a single treatment. But they improved for months or even years before they plateaued.

With all that said, we applaud Tony’s stem cell advocacy. He gives hope to 10’s of millions of people living with debilitating conditions unsatisfied with conventional and integrative medicine.

Back to Tony’s Story
Tony’s story begins: “I have to admit, I was acting more like a 14-year-old at the time, tearing down a mountain in Sun Valley, Idaho, on my snowboard. It went horribly wrong, and I fell with a bone-rattling force that annihilated my shoulder.

It turned out that I’d torn my rotator cuff, the set of tendons and muscles connecting the upper arm to the shoulder. Over the years, I’d dealt with lots of pain. This hurt so brutally that I didn’t know what to do with myself. On a scale of one to ten, I’d award this pain a score of 9.9!    My nerves were on fire. Deep breaths even hurt. Over the next two nights, I slept a grand total of two hours.” Ouch.

The melodrama continued. More on that in a moment, first let us fact-check Tony’s science presentation.

Fat Fact-checking
The cognitive bias begins when Tony credits Dr. Bob Hariri with discovering stem cells in placentas doomed for the dumpster. Then Bob tosses “autologous fat-stem cells” into the medical waste in two ways. He fails to mention:

1. Zuk et al.’s 1999 discovery in a UCLA lab that adipose tissue is the most accessible, abundant, and potent source of mesenchymal stem cells (MSCs), and

2. Adipose tissue contains a mixed population of stem cells and other regenerative cells. Researchers call these autologous Adipose-Derived Regenerative Cells or ADRCs.

He reasons that stem cells from bone marrow, skin, or adipose tissue decline in number and potency as we age. Hariri calls this process stem cell exhaustion. Thus, he argues cultured allogeneic or donor placental-derived MSCs (PD-MSCs) are pristine. Umbilical-cord-derived MSCs (UC-MSCs) are next best. The hypothesis is making sense – so far.

But just because it’s logical doesn’t mean it’s true. James Willerson, MD, Ph.D., and Emerson Perin, MD, Ph.D., from Texas Heart Institute, contradicted Bob’s argument in Buying New Soul (2012).[1]

Adipose tissue seems to be a promising source of stem cells…The resiliency of adipose tissue is evidenced by patients’ ability to gain weight easily even in the presence of multiple comorbidities known to inhibit stem cell function. It may be that certain tissues are less exposed to the detrimental effects of disease and aging.”

Notably, investigators have published over 85,000 papers discussing adipose-derived stem cells (ADSCs). That is an average of 11 new publications per day over the past 22 years. The publishing rate has accelerated to 36 per day, nearly four times the historical average.

A PubMed search finds less than half as many publications on Placenta-derived stem cells (PDSCs).

Jack Nicklaus’ Stem Cell Therapy Hole-in-One
After Bob gave fat a lousy score, Tony recounted meeting Jack Nicklaus at the Vatican Stem Cell Summit. Here, Jack told the audience about his stem cell therapy hole-in-one. Stem cells “helped me go from not being able to stand for longer than 10 minutes, to playing golf and hitting the tennis ball again without pain. They will dramatically enhance your life!”

Apparently, Tony didn’t know prof Dr. Eckhard Alt treated Jack’s back with ADRCs. The your-fat-stem cells-are-too-old theory missed the cut here: Jack was in his late 70s when he opted to go to Germany for autologous ADRCs.

Note, Jack said “helped me” – stem cells are the fertilizer – physical therapy, appropriate exercise, and a healthy lifestyle are the gardeners that restore health.

Finally, our groups in the Bahamas and the U.S. have treated ~400 patients with ADRCs.

We counted every patient’s total nucleated cell (TNCs) with the NucleoCounter. A TNC contains DNA, which makes the cell active. Red blood cells do not have a nucleus and thus have no therapeutic effect. A review of the stats proves Dr. Willerson’s point: ADRCs’ yield, viability, and, most important, outcomes do not suffer from age.

Two over-70 patients with multiple morbidities hold the male and female records for highest yields and viability.

  • Nancy, a skinny long-term smoker with COPD, arthritis, and dermatitis, and
  • Bob, an obese man with polyarthritis, a rare neurologic condition, migraine headaches, and frailty.

On the other side of the coin, a 15-year-old spinal cord injury patient’s yield was right up there with Bob. Six months post-cell therapy and more than one year after his catastrophic injury, the young man regained bilateral motor control of his hip flexors and quads. Standard of Care SCI patients plateau at about 12-months – remarkably, this young man’s path is accelerating.

Most profound, our patients with multiple chronic conditions, including diabetes, heart, kidney, and autoimmune diseases – including obese patients – report high patient satisfaction.

Back to Tony’s story
Three specialists advised surgery. Then one injected PRP but must have hit a nerve as Tony’s arm went limp while performing. Next, a doctor recommended Pulsed Electro-Magnetic Field Therapy (PEMF). PEMF helped: His pain score reduced to 4.5. Tony continued PEMF until he arrived in Panama. Presumably, his pretreatment score pain was lower still.

The Panama clinic gave him three IV shots of umbilical cord-derived mesenchymal stem cells (UB-MSCs) over three days. On the first day, a doctor injected stem cells into his shoulder – but not his back.

On day two, Tony had an adverse event: “…I had what’s often called a “cytokine response.” I felt chills and shaking, but I wasn’t scared. They told me it was normal: “Your body’s healing, just get some rest.”

At the risk of offending Tony or the clinic staff: A cytokine response is an abnormal reaction.    The body’s immune system recognized the donor stem cells as foreign (or contaminated). These reactions do not occur with autologous ADRCs.

By the way, we respect Neil Riordan, Ph.D., CEO of the Stem Cell Clinic of Panama. He co-authored three early, highly cited papers on stromal vascular fraction (the generic term for ADRCs).

Recent research clarifies that donor stem cells are “immune-evasive, not immune-privileged,” counter to the proponents of allogeneic cell therapy.[2] [3] Simply put, the Panamanian UB-MSCs and Tony’s immune system were not a perfect match. Married couples fight from time to time but can still be happy. Perhaps, that was the case with Panama clinic’s Golden Cells. They had a little spat and got on with it.

Thankfully, Tony says the shaking lasted 20 minutes. He did not allow how long the chills lasted or if he caught a fever. Published clinical trials report allogeneic MSC infusions often cause transient fevers. This side-effect is mild, particularly compared to the risks of surgeries, drugs, and devices.

Miraculously, 15 years of back pain and shoulder pain were gone for good on the third day, Tony stated. He does not specify if the injection doctor was board-certified in pain management. Of if the shoulder injections were done under ultrasound? As one reads on, the story gets confusing.

The stem cells took effect on day three – but we don’t know for how long or how much.

And here is the rub: The continuing story makes it hard to attribute the awe-inspiring, new-life proclamation to life force UB-MSCs alone. That is ok – if Tony’s fans understand that. First, his shoulder may not have been in that much pain, thanks to the PEMF and conventional care, i.e., ice, PT, and rest. And resting during the three-day protocol may have decompressed his spine.

Plus, he indulges in multiple biohacks per day for pain and inflammation.

Here is the point: Unrealistic expectations lead to disappointed patients. But they are thrilled when stem cell therapy helps them live a better life.

As Tony’s research, therapy, and investment journey twists and turns like Jack’s back did when he played the PGA tour, Tony accesses innumerable tools for his health:

  • Cryo-therapy,
  • Counter-strain physical therapy,
  • Laser therapy
  • Hyperbaric oxygen therapy,
  • PEMF therapy
  • Egoscue exercises,
  • Supplements,
  • Sauna,
  • Exosomes,
  • Stem cells, etc.

Last but not least, his story double-bogeyed with exosomes, nano-sized sacs of growth factors secreted from MSCs. “I personally used exosomes along with stem cells to address a variety of challenges I experienced as a result of the work I had done on my shoulder that I told you about in Chapter 2,”

What? Tony said Panama stem cells resolved those challenges on Day Three.

For reasons best known to biohackers and God, there is a growing misbelief that exosomes are more effective than MSCs. That science discussion is beyond the scope of this review. Suffice to say, MSCs release exosomes, growth factors, hormones, and anti-inflammatory cytokines in a single dose.

Significantly, ADRCs secrete hundreds more healing or trophic factors than cultured MSCs do alone.[4]  All these attributes place clinical-grade ADRCs at the top of the leader board.

However, that doesn’t mean PD-MSCs, UB-MSCs, and BM-MSCs aren’t effective. They can shoot par. But safety and effectiveness depend on complying with Good Lab Practices (GLPs), the culturing method, and other technical specifications. Pew Trusts exposed contamination-related adverse events when doctors treat patients with cheap and cheerful stem cell products.

AMBROSE’s use of the Celution™ cell processing system and compliance with the Federal Right to Try Act of 2017 underpins our pristine cell-related safety record.

Tony is a Humanitarian. He has inspired millions of people to live better lives and means Life Force to do the same thing. His 1100-page 17-hour listen does so.

However, he diluted his sincere intentions with cognitive bias, contradictory evidence, conflicts of interest, and hyperbole. Our forensic review of the stem cell commentary suggests other information in the book suffered the same fate.

Life Force is a best-seller.

[1] J. Willerson and E. Perin Buying New Soul J Am Coll Cardiol. 2012;60(21):2250-2251

[2] Berglund et al. Immunoprivileged no more: measuring the immunogenicity of allogeneic adult mesenchymal stem cells Stem Cell Research & Therapy (2017) 8:288

[3] Akrum et al Mesenchymal stem cells: immune evasive, not immune privileged Nat Biotechnol. 2014 March ;32(3):252–260

[4] Hirosi Y et al. Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/ stem cells in the same individuals

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The Power of Simplicity in Health and Wellness

The Power of Simplicity in Health and Wellness

The Power of Simplicity in Health and Wellness

We often undervalue the Power of Simplicity in our health and wellness.

At one end of the spectrum, the standard of care extends our lifespans, i.e., drugs, surgery, and devices.But the average senior sees seven doctors and takes seven meds per year. Thus, we all know someone – or are that someone – who lives with a poor quality of life.Self-proclaimed biohacking broscientists are on the other end of the spectrum.If something might just help your health – no proof required- one of the broscientists will sell or promote it. In doing so, they claim their products, equipment, books, podcasts, and psychedelic drugs are the solution to everything from chronic disease to healthy aging.

The Power of Simplicity
Instead, you can be the hero of your health by taking control of your mind and body with simple lifestyle practices. Better yet, these tools cost nothing but a bit of time. And they bring enjoyment to you and others with whom you live, work, and play.

The pillars of healthy aging are moderate exercise, an anti-inflammatory diet, a strong family, and fun, supportive friends. It’s “too simple.”

  • Study after study demonstrates walking would be a trillion-dollar drug – if big pharma could put it in a vial and sell it. Healthline says their top 10 benefits include heart health, lower blood sugar, boosted energy, living longer, creative thinking, and more.
    A trial led by the University of Massachusetts found that walking about three miles per day cut the risk of dying by more than half. Surprisingly, people who walked further or faster did not live longer. According to the Cleveland Clinic, too much exercise can hurt you. In other words, you don’t have to be a weekend warrior to be healthy.
  • The Harvard School of Public Health supports the age-old Mediterranean diet. If you start the Mediterranean diet before the age of 80, you will outlive at least three of your friends who eat the western diet. Our Italian, Spanish, and Greek friends who consume more olive oil, fruits, vegetables, nuts, and seafood than Americans have a lower risk of heart disease, stroke, dementia, and depression.
  • Dan Buettner studied five communities in Japan, Italy, Greece, Costa Rica, and California. In these five Blue Zones, more 90-year old’s live with vim and vigor than anywhere else on the planet. His talk, How to live to be 100+, ties together the common denominators regarding exercise, diet, community, and purpose that Buettner’s research unearthed. Suffice to say, people in these communities walk a lot.
  • At 33, Lissa Rankin, M.D., was a burned-out ob-gyn physician. She was taking seven medications to treat a whole host of conditions.  Her successful search for better personal health led Lissa to mind-over-body medicine.  In her TEDx Talk, Is there scientific proof we can heal ourselves?, Lissa names research studies that show friendships, long-term relationships, a positive frame of mind, and relaxation exceed the benefits of exercise and diet alone.
  • In Shut your Mouth and Change your Life, Patrick McKeown explains how simply switching from mouth breathing to nasal breathing improved his asthma, sleep, and focus. Gentle, slow nasal breathing enhances heart health, lung function, sexual fitness, immune strength, and a heightened sense of well-being. He gives new meaning to a breath of fresh air. And breathwork isn’t new: Medical research attributes the benefits of meditation and yoga to it.

But for some people, healthy living isn’t enough, or it came too late.  After failing conventional and integrative medicine, Barbara, Jeff, Tony, Trish, and others credit accessing their adipose-derived stem and regenerative cells (ADRCs) with their improved quality of life. In this way, ADRCs bring a Golden Era of Self-Cell Repair to healthcare.

In summary, these mind-body wellness tools are the keys to the healthspan kingdom.

Conversely, extreme biohacking may just be the new stupid.  In this realm, “broscience” geniuses Dave Asprey, Joe Rogan, and Ben Greenfield score healthcare IQs below the room temperature.

Like big pharma, biohacking is big business. If we stacked on top of one another all the equipment, products, supplements, coffee, food, books, course materials, franchise documents, blog posts, and transcripts the big three market, it would be the height of a 10-story super-store.

The polar opposites are the stars of the back-to-basics formula.  They are everyday folks who enjoy life into their 80s, 90s, and 100s with intact memories, healthy hearts, and rich social lives.

 

The millions of scientific papers supporting the Power of Simplicity in health could encircle the earth.On a personal basis, the pillars of the Power of Simplicity encompass the future of healthy, happy, and dignified aging. And you can splurge on them without having to spend any money at the Biohacking Superstore.

​*Gross motor (physical) skills, those which require whole body movement and which involve the large (core stabilizing) muscles of the body to perform everyday functions, such as standing and walking, running and jumping, and sitting upright at the table. They also includes eye-hand coordination skills such as ball skills (throwing, catching, kicking) as well as riding a bike or a scooter and swimming.

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Is a Golden Era of Spine Care Ahead?

Is a Golden Era of Spine Care Ahead?

Is a Golden Era of Spine Care Ahead?

In 2016, Barbara suffered from debilitating spinal stenosis. After failing to respond to chiropracty, physical therapy, medication, and steroids, Barb accessed a new option: The stem cells and other regenerative cells residing in her fat or adipose-derived regenerative cells (ADRCs). Five years since her treatment, Barb says that cell therapy “saved my future.”

In 2018, Trish, Jeff, and Kathy lived with complex, debilitating health conditions, including spine-related pain. After they had failed to get relief from conventional and integrative medicine, each chose to exercise their Right to Try AMBROSE Cell Therapy under the Federal Right to Try Act of 2017. Remarkably, over two years post-cell therapy, they all report their spine-related symptoms and dysfunction don’t hold them back anymore. But what is the scientific back story that led to their sustained outcomes? And what was the catalyst for a Golden Era of Spine Care?

 Is Conventional Spine Care Antiquated?
Spine care has its origins in antiquity. The Edwin Smith surgical papyrus, an Egyptian document written in the 17th century BC, is the first known discussion of neck and back-related injuries. Hippocrates (4th century BC) experimented with traction or local pressure to correct spinal deformities. Aristotle also contributed to our current day understanding of the neck and spine.

Few individuals in history have made as many contributions to so many disciplines as Leonardo da Vinci. Included in his vast body of work, Da Vinci sketched the first accurate depiction of the spine. [1]

As a result, knowledge of the neck and back, and their related disorders, have evolved since the Renaissance Man’s illustrations.

Early researchers proposed that neck and back pain resulted from the stress of heavy loads and age-related wear and tear on the discs. Then, in 1978, White and Panjabi published Clinical Biomechanics of the Spine. Here, they connected all the mechanical factors involved in neck and back health.  Technically speaking, they found that in addition to vertebrae, our muscles, tendons, ligaments, blood vessels, and nerves (soft tissues) play significant roles in spine health and disease. White and Panjabi named those pieces of the puzzle the Functional Spine Unit (FSU).

But there was still more to be discovered than the FSU. More recently, researchers began focusing on the vicious interplay involved with traumatic injuries, wear and tear, inflammation, and other diseases (co-morbidities). For example, patients with heart disease, diabetes, neurologic conditions, and autoimmune diseases have a higher prevalence of spine disorders than others without those conditions. In fact, Barb, Trish, Kathy, and Jeff each lived with other chronic debilitating conditions, including arthritis, hypermobility, kidney failure, and spinal cord injury, respectively. [2] [3] [4] [5]

In 2001, Patricia Zuk, Ph.D. et al., working in a UCLA lab, accomplished a (non-obvious) leap forward for patients living with neck and back pain. Zuk’s group discovered mesenchymal stem cells (MSCs) were residing in adipose tissue. But how did their seemingly unrelated research catalyze a Golden Era of Spine care? We will answer that in a moment first; why was a new regenerative option needed in the first place?

 Failed Back Surgery Syndrome
Despite those thousands of years of research and development, more people than ever are suffering from spine-related pain. Besides contributing to the opioid epidemic, the number of spine surgeries increases year in and year out.

Unfortunately, downsides to spine surgery, including high rates of complications, readmissions to the hospital, and poor outcomes, are common. [6] [7] As a result, approximately 4 million individuals live with failed back surgery syndrome (FBSS) in the U.S. Tragically, a spinal fusion gone wrong caused Jeff’s spinal cord injury.

Doctors call those with FBBS and others unwilling to risk a surgical intervention “no-option patients. Jeff’s spinal cord injury resulted from a spine surgery, which upon a second opinion, turned out to be unnecessary in the first place. Barb, Kathy, and Trish opted not to pursue surgery out of concern for those risks.”

 Is there more to spine health than meets the eye?
Circling back, in the early 1500s, Leonardo da Vinci took an unusual interest in tree anatomy. His Rule of Trees explained the balance between the trunk and branches of a tree. He counted the rings in tree trunks to determine “the nature of past seasons.”

Perhaps it wasn’t coincidental that he sketched the spine, tree trunk, and branches, respectively? Let’s look at it this way: The tree’s trunk supports the crown and branches. Likewise, a healthy neck and back do the work of a strong tree.  But even the strongest and thickest tree branch cannot handle a heavy load if the tree’s trunk is weak. Similarly, our legs, arms, hands, and feet can be affected by a degenerated FSU.

Ideally, our spines are a harmony of functional bones and soft tissues. The back and neck rely on all those elements to hold us upright and be mobile. But when the soft tissues atrophy or become arthritic, they pressure nerves, thus contributing to spine-related symptoms.

  • Trish lived with sciatica, numbness, stiffness, and pain.
  • Kathy’s bad neck kept her awake at night.
  • Barbara’s situation prevented her from working, gardening, driving, and pottery.

Most vexing, back-related discomfort doesn’t discriminate: Gardners, crossfitters, weightlifters, golfers, and aging couch potatoes can end up unable to function without pain for varied reasons. [8]

ADRCs – the Spine’s Arborist
An arborist cultivates trees; tree removal is a last resort. The first thing that goes through their minds is how to save the tree. To do their jobs, arborists cultivate the whole tree. They use fertilizer, irrigation, and other regenerative tools to restore the tree’s trunk, limbs, and leaves.

Around 2010, Zuk’s discovery of stem cells in fat came into play when some innovative doctors began treating spine patients with ADRC-based protocols. Their strategy was not dissimilar to an arborist’s. They recognized that a veritable pharmacopeia in a person’s fatty tissue could reduce arthritis and regenerate the supportive soft tissues in the neck and lower back. Back surgeries change the anatomy while cell therapy is, well, therapeutic.

Just as an arborist uses an array of skills to rehabilitate diseased trees, ADRCs use multiple mechanisms of action to rehab the FSU. At least as necessary, ADRCs restore balance or homeostasis in the systems that feed, care for, and defend the spine. In other words, better vascular, immune, metabolic, and nervous system wellness contributes to overall improvements.

In summary, not only did AMBROSE cell therapy help Barb, Jeff, Kathy, and Trish avoid risky surgeries, but all reported being more active, increased energy, and an improved sense of wellbeing.

[1] Bowen G et al Leonardo da Vinci (1452–1519) and his depictions of the human spine
Childs Nerv Syst (2017) 33:2067–2070

[2] M. Shamji et al. Proinflammatory Cytokine Expression Profile in Degenerated and Herniated Human Intervertebral Disc Tissues Arthritis Rheum. 2010 July; 62(7): 1974–1982

[3] J Gallo Inflammation and its resolution and the musculoskeletal system J Orthop Translat. 2017 July; 10: 52–67

[4] Asadian et al. Diabetes Mellitus, a new risk Factor for lumbar spinal stenosis: a Case–Control study. Clinical Medicine Insights: Endocrinology and Diabetes 2016:9 1–5

[5] Lotan R, Oron A, Anekstein Y, Shalmon E, Mirovsky Y. Lumbar stenosis and systemic diseases: is there any relevance? J. Spinal Disord. Tech. 2008;21(4):247-51.

[6] Camino Willhuber et al. Analysis of Postoperative Complications in Spinal Surgery, Hospital Length of Stay, and Unplanned Readmission: Application of Dindo-Clavien Classification to Spine Surgery Global Spine Journal July 2018

[7] Chase D. The opioid crisis is partly fueled by insurers and employers’ approach to back pain. StatNews. statnews.com/2019/03/27/opioid-crisis-insurersemployers- back-pain/. Published March 27, 2019.

[8] J Abbas et al Paraspinal muscles density: a marker for degenerative lumbar spinal stenosis? BMC Musculoskeletal Disorders (2016) 17:422

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Has a Golden Era of Diabetes Care Begun?

Has a Golden Era of Diabetes Care Begun?

Has a Golden Era of Diabetes Care Begun?

Amy’s Six-Year Patient-Reported Outcome Suggests So.

After living with severe diabetic neuropathy and fibromyalgia, in 2014, Amy, a then 24-year-old T1 diabetic, accessed the stem cells and other regenerative cells in her fat (adipose tissue) to improve her quality of life. That single treatment of adipose-derived regenerative cells (ADRCs) marked the turning point in Amy’s battle with diabetes. Amy’s every day went from being ruled by her foot pain to playing soccer, hiking the Grand Canyon, and living life to the fullest.

Amy didn’t go on a highly restrictive diet or make radical lifestyle changes on her way to improved symptoms, function, and quality of life. That isn’t to say those tools aren’t helpful for some; Amy just didn’t need them after cell therapy. Neither are we saying that her food choices and exercise regimens weren’t healthy; they just weren’t extreme.

To put Amy’s patient-reported outcome in perspective, let’s contrast it with the standard of care for chronic disease. A single dose of medicine rarely, if ever, provides lasting benefits. We often take prescribed drugs for life – unless they don’t work or the side-effects are not bearable by the patient.

Seniors, on average, take seven medicines and see seven doctors per year.

Those pursuing a more natural route take supplements daily, repeat integrative therapies for extended periods, go to the chiropractor when their bones and muscles go out of tune, and so forth.

The standard of care for people living with diabetes, concurrent with other diseases (co-morbidities) requires the patient to take multiple drugs daily to address each condition.

Not to be glossed over, Amy’s improvement for multiple morbidities resulted from a single, same-day treatment with ADRCs. Her benefits from cell therapy have now spanned more than six years and continue. If Amy needs a repeat treatment at some point or another, her win would still indicate a new standard of care for patients living with diabetes is afoot.

Or, as better put by Amy, instead of living in constant fear of her next flare, she can dream again. Broadly speaking, ADRC-based treatments bring creditable hope to people living with diabetes and related illnesses.

Notably, other tools can provide significant benefits to people with diabetes. For people living with T1D like Amy, continuous glucose monitoring (CGM) paired with an automated insulin pump makes a positive difference. For those with T2d, diet and managing blood sugars with CGM can change the disease’s progression or, if caught early enough, reverse it.

Amy’s self-cell therapy (using ADRCs) changed the course of her life. Her results and others like her signal that a Golden Era of  Diabetes Care has begun.

You can find Amy’s Patient-Reported outcome here.

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If You Are Unique, Why are You Treated As an Average Patient

If You Are Unique, Why are You Treated As an Average Patient

If You Are Unique, Why are You Treated As an Average Patient

Kathy’s Patient-reported Outcome – Inherited Kidney Disease

 

“All happy families resemble one another, each unhappy family is unhappy in its own way.
Leo Tolstoy

Like all patients with a chronic disease, Kathy was symptomatic in her own way. With 5% kidney function, regeneration was not an expectation. She faced a sure path to dialysis, to be followed by a kidney transplant. Kathy also had neck and hip pain. Just before starting dialysis, she exercised her Right to Try AMBROSE Cell Therapy.

Kathy’s patient-reported outcome provides a look at the unique benefits a patient can have by accessing one’s adipose (fat)-derived regenerative cells (ADRCs). Said differently, just as an individual’s symptoms differ, so are the improvements that can be achieved in one’s quality of life.

Our bodies are much the same as Tolstoy describes families. When we are healthy, we enjoy exercise, sleep well, and lead active lives. In health, we are all pretty much the same.

In contrast, a group of patients diagnosed with the same disease will have symptoms unique to each in their own way:

  • Many patients diagnosed with Parkinson’s disease have tremors, but others do not.
  • Heart disease may or may not include high blood pressure, irregular heart rhythms, hardening of the arteries, chest pain, or shortness of breath.
  • Some patients have arthritis in one joint, and others have multiple joints that are stiff and painful – not to mention possible bowel or skin issues.

When we ask “Dr. Google,” What causes fatigue and dizziness? a top search result lists nine possible causes.  Thus, diagnosis is problematic. Chronic conditions include different horns (symptoms) of the same devil (diagnosis). And different devils share many of the same horns.

As the Washington Post reported, Mayo Clinic found that more than 20 percent of patients are misdiagnosed by their primary care physician (PCP). But that is not because the PCPs do not meet Mayo’s standards. They get it wrong too.

The story goes on to explain, “Diagnosis is extremely hard,” said Mark L. Graber, a senior fellow at the research institute RTI International and founder of the Society to Improve Diagnosis in Medicine. “There are 10,000 diseases and only 200 to 300 symptoms.”

Mr. Graber’s stats help explain why there are so many disease spectrums. Our symptoms and how our bodies function (physiology) vary – even if we have the same diagnosis. Adding to the complexity, some patients have few if any symptoms, while others suffer badly with the same diagnostic findings. Most vexing, the degenerative process of one disease often leads to co-morbidities.

The Epic Failure of Large Clinical Trials – Solving for the Average
Despite the uniqueness of our physical complaints, the standard of care relies on clinical trials with thousands of patients. The goal is to determine an experimental drug, device, or surgery’s safety and efficacy. That makes sense – at least on the surface. The trouble is that large trials “solve for the average,” but you are not an average patient. There is no such thing. Our unique differences in mind, body, family history, and lifestyle determine which devils and which horns with which we might suffer.

Personalized medicine is trying to solve for the individual. Here doctors:

  • Use genetic testing to help determine the risk of inheriting a disease,
  • Assess your gut for bad actors underlying a chronic condition,
  • Evaluate inflammatory markers in your blood that may lead to heart disease, diabetes, or other illnesses, and so forth.

Though that approach is promising, little benefit for large populations has resulted from extensive testing. Why? Because doctors still rely on the standard of care, rather than personalized medicines, for prescribed treatments. Without personalized drugs, doctors have no choice but to solve for the average instead of the individual.

What does this mean in the real world?
In contrast to conventional medicines, ADRCs are unique to you. They are a personalized pharmacy residing in your body. Each cell in the ADRC population is in our blood, tissues, and organs, respectively. Their purpose in the body is to keep our bodily systems – vascular, immune, endocrine, and nervous systems – as well as our tissues in balance (homeostasis).

Admittedly, we can only make assumptions about why Kathy’s quality of life improved so much from AMBROSE Cell Therapy. Our thesis is that the IV of ADRCs brought her bodily systems toward homeostasis. The mechanisms may include, along with others, a systemic reduction in chronic inflammation and abnormal immune response aided by improved blood flow. Many other good things can result from such improvements. And the direct injections initiated a process of rescue and repair in Kathy’s neck and hip.[1][2]

At the end of the day, what matters most to Kathy is the improvement in her quality of life, despite the risk that it would worsen with dialysis and a kidney transplant.

​*Gross motor (physical) skills, those which require whole body movement and which involve the large (core stabilizing) muscles of the body to perform everyday functions, such as standing and walking, running and jumping, and sitting upright at the table. They also includes eye-hand coordination skills such as ball skills (throwing, catching, kicking) as well as riding a bike or a scooter and swimming.

[1] B.A. Tompkins et al Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial J Gerontol A Biol Sci Med Sci, 2017, Vol. 72, No. 11, 1513–1521

[2]  S. Kesten & J.K. Fraser Autologous Adipose Derived Regenerative Cells: A Platform for Therapeutic Applications Advanced Wound Healing SURGICAL TECHNOLOGY INTERNATIONAL XXIX

AMBROSE Cell Therapy

Your Right to Try

Golden Era of Self-Cell Repair

Golden Era of Self-Cell Repair

Golden Era of Self-Cell Repair

Tony had tried pretty much everything that conventional medicine had to offer. He had also given natural solutions such as supplements, hormones, and diet changes a shot as well, yet he was still in pain. Tony was facing multiple joint replacements and surgeries.  A new law, the Federal Right to Try Act of 2017, empowered Tony to try a new option. His 18-month patient-reported outcome is remarkable. As he reported, “To be candid, the difference in the quality of my life is just unbelievable. You can’t describe to someone what it is like to live without that ever-present and often excruciating pain.” Is a Golden Era of Healthcare within our grasp?

Many millions of people live with (and die because of) poor health despite treatment with surgery, drugs, and devices (the standard of care).  Doctors refer to these patients as “no-option.” They are considered resistant to treatment. Put simply, the standard of care isn’t working well – if at all – for no-option patients.  Some get relief from natural solutions such as diets, supplements, and the like (integrative medicine). But many, including Tony, also fail to achieve sustained benefit from those.

In 1991, Arnold Caplan, Ph.D., in his foundational paper, Mesenchymal Stem Cells. created a vision “for the emergence of a new therapeutic technology of ‘self-cell repair’ (emphasis added).” With that, Dr. Caplan conceived of a new standard of care for no-option patients like Tony and set the foundation for a Golden Era of Healthcare.

We will dig into what Self-Cell Repair means and how the science has evolved since Dr. Caplan first presented its potential. We will also share Tony’s full patient-reported outcome. And fill in the blanks on the Right to Try Act of 2017.

Healthcare’s Gordian Knot
The term “Gordian knot” is commonly used to represent an unsolvable problem. A Roman historian described it as “several knots all so tightly entangled that it was impossible to see how they were fastened.” The name traces back to a legendary event where Alexander the Great used his wit and cunning to cut the Gordian Knot.

Alexander’s feat is trivial compared to untying the intricate web of tangles involved in caring for no-option patients.   This dilemma is even more complicated than it may first appear.

  • Over 100 million American adults are living with two or more chronic illnesses (co-morbidities).
  • For seniors, it is even more daunting: 68% (38 million) have two or more, and 40% (22 million) have five or more chronic conditions, respectively.
  • On average, those 65 and over go to seven doctors and take seven meds per year.[1]

 

Epic Failure of Conventional Medicine
All of us know someone who is living with one or more chronic conditions:

  • Perhaps a friend had back surgery, and two years later, they are back in the soup with disabling pain. There are more than 4 million patients with “failed back” (surgery) syndrome.
  • Or, a family member has both heart disease and diabetes. Over 10 million people in the U.S. have this life-threatening combination.
  • More than 2 million patients in the U.S. have both rheumatoid arthritis and psoriasis. R.A. involves inflamed and painful joints. Psoriasis is a skin disease. The combination of the two is so prevalent it has morphed into one diagnosis, psoriatic arthritis.
  • Over 20 million Americans live with incurable neuropathies (nerve pain or numbness).

Our reliance on conventional medicine is rooted in thousands of years of development and practice. Corporations, investors, government agencies, and research institutions invest hundreds of billions per year to improve the standard of care. Yet, as the stats above tell us, the number of people living with one or more chronic diseases has become a crisis of magnitude.

  • The conventional drugs used to treat long-term maladies such as rheumatoid arthritis (R.A.), Parkinson’s Disease, heart disease, and diabetes cost between $25,000 – $50,000 (or more) per year.
  • Worse, these meds do not cure the prescribed for conditions – and they often come with intolerable side effects. For too many ill people, “the cure is worse than the disease”;
  • Hence, many patients discontinue use or refuse to take their prescribed drugs—non-compliance then piles on even more cost.

Despite the costs and risks, big pharma makes tens of billions off of their blockbuster drugs. And, they unapologetically raise prices 10% a year in and year out.

Tony was just one of the millions of patients in search of a new standard of care.

What is Self-Cell Repair?
Returning to Dr. Caplan’s 1991 paper, Mesenchymal Stem Cells, he described MSCs as adult stem cells. He explained that MSCs could change into (differentiate) into multiple tissue types as well as neurons and blood vessels and self-renew. In other words, he hypothesized that MSCs would grow of new heart muscle, cartilage, nerves, or blood vessels in man.

What Are Adult Stem Cells? | AMBROSE Cell Therapy

A Surprising Discovery
In an unexpected twist, Dr. Caplan proposed to change the name of MSCs to Medicinal Signaling Cells in 2010. He wants to drop the reference to stem cells altogether.[2]  To paraphrase his thinking, MSCs release hundreds of beneficial signaling molecules called cytokines. These cytokines tell the resident stem cells at the site of injury or disease to do their jobs. As it turns out, the benefits of MSCs come from what the cytokines do rather than what the MSCs become.

In other words, we have our own personalized “pharmacy” that knows how our body and its systems work. When there is something abnormal or out of balance, the cytokines go to where they are needed – sites of inflammation.  They then signal the resident stem cells to get to work and set it right. This nearby cell-to-cell communication is called the paracrine effect.

As a testament to Dr. Caplan’s vision and research, according to a PubMed search, there are over 150,000 published papers that discuss MSCs and 1,000 trials registered on Clinicaltrials.gov, respectively.

What does fat have to do with all that?
The game-changing breakthrough came in 2001 when Patricia Zuk Ph.D. and others, working in the labs of UCLA, discovered MSCs residing in our fat.[3]   And that adipose-derived MSCs were more accessible, abundant, and potent than those from the bone marrow.

Sources of Stem Cells - Bone Marrow vs Adipose | AMBROSE Cell Therapy

Dr. Zuk’s finding advanced a prior discovery: In the 1960s, a Nobel Prize winner, Martin Rodbell, had isolated a population of regenerative cells in our fatty tissue.

Adipose Tissue - Regenerative Cells (ADRCs)In other words, there is a mixed population of stem cells and other regenerative cells in our fat. When clinical grade, this diverse mix of cells are called Adipose-Derived Regenerative Cells (ADRCs).

Dr. Caplan’s, Dr. Rodbell’s, and Dr. Zuk’s breakthroughs are the foundation for a new standard of care and a Golden Era of Healthcare.

The Gold Standard for Judging Outcomes for Patients like Tony?
Magnetic resonance imaging (MRI) is a test that uses powerful magnets, radio waves, and a computer to make detailed images of the inside of your body. Doctors use MRIs to diagnose everything from the brain to the heart and other organs, as well as your spine and joints. They also use these tests to see how well you’ve responded to treatment.

While MRIs are considered the gold standard for diagnostic imaging, there is a problem with relying solely on their findings. That is because a patient’s symptoms and dysfunction often do not correlate with their structural abnormalities. As but one of many possible examples, patients with significant back pain can have MRIs that are not so bad, yet they are more symptomatic than those with imaging that shows severe signs of degeneration.

The medical establishment relies on MRIs and other diagnostic tests to establish objective evidence that surgery or other treatment worked. In contrast, patients care about their quality of life.

As Tony put it:

What is the “Right to Try”?
“Right to Try” is a new way to express our fundamental “right to life” and “right to health.”

On May 30, 2018, an enlightened and extraordinarily humanitarian bill, The Federal Trickett Wendler, Frank Mongiello, Jordan McLinn, and Matthew Bellina Right to Try Act of 2017 (Right to Try Act), was signed into law by President Trump. [4] [5]  The law provides patients who are seeking new treatment options not approved by the FDA the right and opportunity to do so. The law empowers no-option patients to take control of their health.

Importantly, not all patients with chronic disease meet the criteria. The patient and their doctor determine eligibility under the law.

Golden Era of Healthcare
The great monuments, art, philosophy, architecture, and literature of the Golden Age of Greece (500 BC – 300 BC) are the building blocks of western civilization.

The architects of self-repair cell therapies and the Federal Right to Try Act provide the building blocks for a Golden Era of Healthcare – and a new standard of care for patients like Tony.

To find out whether you might qualify for AMBROSE Cell Therapy under the Right to  Try law, please click here.

To read more about AMBROSE Cell Therapy patient-reported outcomes, including Tony’s, please click here.

​*Gross motor (physical) skills, those which require whole body movement and which involve the large (core stabilizing) muscles of the body to perform everyday functions, such as standing and walking, running and jumping, and sitting upright at the table. They also includes eye-hand coordination skills such as ball skills (throwing, catching, kicking) as well as riding a bike or a scooter and swimming.

[1] http://www.webmd.com/healthy-aging/features/how-many-drugs-are-you-taking#1

[2] A Caplan Mesenchymal Stem Cells: Time to Change the Name! Stem Cells Translational Medicine 2017;6:1445–1451

[3] PA Zuk et al Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001

[4] https://www.congress.gov/115/bills/s204/BILLS-115s204enr.pdf

AMBROSE Cell Therapy

Your Right to Try

Natural Law – Your Right to Try

Natural Law – Your Right to Try

Natural Law – Your Right to Try

Natural Laws are a body of unchanging moral principles derived from nature. As the basis for all human conduct, they transcend time, culture, and government. Aristotle is known as the father of Natural Law. In Rhetoric, he proposed that there is a “common law” or “higher law” that is according to nature.

The natural law framework led to the concept of “Natural Rights.” The philosopher John Locke defined Natural Rights as a person’s rights to life, liberty, and property. Locke believed that the most basic human law of nature is the preservation of humanity. To serve that purpose, he reasoned, individuals have both a right and a duty to preserve their own lives.

These principles have become universal with The Declaration of Independence (1776) of the United States, the Declaration of the Rights of Man and of the Citizen (1789) of France, the Universal Declaration of Human Rights (1948) of the United Nations as well as the European Convention on Human Rights (1953) of the Council of Europe.

The Federal Right to Try Act of 2017 is the most current way of expressing our natural right to restore our health and preserve our own lives. It gives new options to patients with life-threatening and debilitating conditions, who have failed – or are not amenable to – accepted surgeries, drugs, or devices.

Federal Right to Try Act - Ambrose Cell Therapy

There are a surprising number of adults living with complex chronic degenerative conditions, particularly those with multiple diseases (morbidities).

One such patient was Tony. In September 2018, he was facing multiple joint replacements and surgeries due to debilitating chronic inflammation and osteoarthritis in his knees, left hip, both shoulders, and fingers. Instead of operations or drugs, he exercised his ‘Right to Try” AMBROSE Cell Therapy. Now over a year and a half out, Tony is pleased to report his remarkable improvement in pain scores, mobility, function, and quality of life. Here is his inspiring Patient Reported Outcome.

Biodistribution of Adult Stem Cells

Biodistribution of Adult Stem Cells

Biodistribution of Adult Stem Cells

Mesenchymal Stem Cells

In 1991, Professor Arnold Caplan published the seminal paper, Mesenchymal Stem Cells (MSCs). In the article, he described MSCs as having the ability to differentiate and self-renew into multiple tissue types, as well as neurons and blood vessels. [1] In other words, they are ‘multipotent,’ meaning they can produce more than one type of specialized cell of the body, but not all types. Differentiation and self-renewal are the unique characteristics required of a cell to be a stem cell.

What Are Adult Stem Cells? | AMBROSE Cell Therapy

In the article’s introduction, he called MSCs, “the basis for the emergence of a new therapeutic technology of self-cell repair” (emphasis added). His tireless research gained extensive support from hundreds of other scientists. In fact, according to a PubMed search, there are now over 160,000 published papers that discuss MSCs. This vast body of literature has led to a broad agreement as to how these repair cells migrate to and repair diseased tissues and organs. The science has also progressed to include an understanding as to how MSCs restore normal function in our vascular, immune, and endocrine (hormone) systems.

Research has further progressed to include an appreciation of how MSCs do their job (and has led to a proposed new name for them). More on the new name later; first, here is the back story.

Biodistribution

Since the early days of research into MSCs, scientists have been on a quest to determine the optimum delivery route. Much like planning the most efficient course through a labyrinth-like city (such as London), they want our stem cells to stay clear of blind alleys, wrong-way streets, and circuitous routes. The investigators also recognize some courses may be riskier than others – even if seemingly more efficient per the map, e.g., directly injecting stem cells into the brain or the eye.

But there is a new angle to the planning process that is increasingly appreciated by researchers: The underlying role that low-level systemic inflammation (inflammaging) plays in chronic disease and the potential for stem cells to calm that down. More on inflammaging later; first, how do MSCs do their job?

Mechanisms of Action

Mechanism of action (MOA) refers to the way our stem cells (or drugs) produce their effect. In the case of MSCs, their MOAs are analogous to the fire department: They respond to a fire alarm – i.e., an inflammatory signal – and beeline to the source of it. MSCs have been called “guardians of inflammation.” [2] Once they get to the scene of the fire, they release hundreds of bioactive signaling molecules called “cytokines.” The cytokines activate the local cells in the neighborhood to do their jobs. This cell-to-cell communication is called the paracrine effect.

In short, since Dr. Caplan’s groundbreaking paper was published, researchers have verified that homing and the paracrine effect are the central roles of MSCs in the repair process. And so, that is why Prof. Caplan proposed changing the name to “Medicinal Signaling Cells.” [3]

Biodistribution Studies

Biodistribution studies have established that adult stem cells delivered IV migrate through the lungs and “park” there (“first-pass effect”) – and then move on. (There is some confusion as to whether the first-pass effect is a “dead-end street,” but suffice to say, research has established that it is not the case.) [4] [5] [6]

As they continue on their mission to fight inflammation and repair the body, they journey through the vascular system and organs to the spleen, our largest immune organ. They then route through the lymphatic system.

The lymphatic system, which runs parallel to the vascular system, is an essential part of the immune system. It carries lymph (a clear fluid containing a high number of a type of white blood cells called lymphocytes. Lymphocytes fight infection and destroy damaged or abnormal cells. They are abundant in the mixed population of cells accessed from our adipose tissue for cellular therapies.

Biodistribution Studies

A well-designed study of IV infusion of adult stem cells in baboons tracked the migration. The graph below shows distribution to all of the major internal body organs. [7]

Add to that, in a cardiac cell therapy study, researchers at Texas Heart Institute and MD Anderson tracked stem cells injected in the hearts of pigs. They also found the MSCs traveled through the blood vessel system into the spleen and then continued to move through the lymphatics. [8]

As a side note, lest we discount the potential of self-cell repair, a study in mice found that systemically delivered adult stem cells could repair chemically-induced corneal damage – without there being any of the MSCs directly applied to the cornea. [9]

Summary
For more on why AMBROSE accesses the MSCs and other regenerative cells from your adipose tissue, please read Why Adipose Tissue. Connecting this back to our Areas of Focus and Our Protocol, ADRCs, delivered IV, have the potential to home to all of the major organs and initiate a process of repair.


 

Chronic Inflammation – Is that all there is to disease?

Chronic Inflammation – Is that all there is to disease?

Chronic Inflammation – Is that all there is to disease?

Chronic systemic inflammation (CSI) is a hot topic. This is for good reason as it is nearly universally agreed that CSI is a culprit in all chronic diseases of aging.

Major media outlets like the Washington Post and New York Times have featured stories on CSI. Raw and Red-Hot, summarized some of Harvard Medical School’s (and their affiliated institutions) enlightening studies on the subject.

By accessing the stem cells (and other regenerative cells) in our fat (adipose tissue), under the auspices of the Federal Right to Try Act of 2017, those with debilitating chronic systemic inflammatory conditions have access to a new option to improve their quality of life. You can read more about the Right to Try Act here.

But is inflammation all there is to it?
The intense focus on chronic inflammation (also known as “inflammaging”) has, in many instances, served to deemphasize (or even ignore) the other factors that are also commonly involved in chronic diseases. More on that in a moment; first the story of inflammation and the largely untold story of the biggest unmet need in healthcare – patients with multiple chronic diseases.

Inflammation
Inflammation isn’t a new idea. It has a long and colorful story. Egyptian papyri from almost 5,000 years ago refer to heat and redness as naturally associated with disease. From another angle, in the 5th century BC, Hippocrates described the beneficial side of inflammation as an early component of the healing process after tissue injury.

Put in everyday terms, short-term increases in inflammation (acute) are critical to repair, and even survival, in the event of physical injury and infection, respectively.

However, it has been revealed that certain social, environmental, trauma-related and lifestyle factors can cause inflammation to go out of control and become chronic. Chronic inflammation is like a smoldering fire inside the body; it slowly spreads, often igniting multiple chronic diseases (morbidities). Patients with multiple morbidities represent the most vexing problem in healthcare.

Given the broadscale recognition of the detrimental effects of inflammaging, there is an irrepressible movement in healthcare (including patients) to do something about it. Conventional doctors prescribe drugs to suppress inflammation, while integrative physicians recommend diets and supplements to tamp it down. Increasingly people (from the “worried well” to the chronically ill) drink green juices and eat kale salads to replace the sugary drinks, bread and desserts they were previously “enjoying” at the expense of their health.

Not to be left out, scientists are researching the pathways and genes in the body that turn excess inflammation on with the hope of discovering small molecules that can be put in a pill to turn it off like a light switch.

But, regardless of all that – and even with some people reporting benefits – the onslaught of chronic diseases of aging has not been reversed nor the prescriptions of drugs, surgeries and devices to fight them slowed.

The Plus Side
On the plus side, for more than 20 years hundreds researchers have described in more than 10,000 peer-reviewed papers, that a mixed population of stem and regenerative cells found in our fat (adipose tissue) can not only improve inflammatory markers, but also address the multiple factors that contribute to the ill health that resulted from inflammaging.

In 2016, researchers summarized the science and studies supporting the unique attributes of ADRCs in a review paper, Autologous Adipose Derived Regenerative Cells: A Platform for Therapeutic Applications.

Trish’s remarkable patient-reported outcome for “hypermobility”, an inherited connective tissue disease, is a profound example of the potential of benefits of AMBROSE Cell Therapy. Her condition had resulted in chronic inflammation, debilitating pain and disability. Unlike others in her family with the same condition, Trish is now able to live life to the fullest. Here is her story.

Compassion Not Greed, Right to Try – Basic Human Rights: Reversals of Disease & Disabilities

Compassion Not Greed, Right to Try – Basic Human Rights: Reversals of Disease & Disabilities

Founder & CEO of Ambrose Cell Therapy, Matthew Feshbach, returns to the show to discuss how his company is making amazing progress towards helping those who have been left behind by traditional medicine. He explains how human fat stores powerful human stem cells which can be used to rebuild tissue, muscle, reduce inflammation and much more. He shares success stories and amazing possibilities for the future.

To listen to the podcast please click the links below:

Part 1 & Part 2