AMBROSE Cell Therapy was founded in 2018 by Matthew Feshbach, with the vision that something could be done about the most vexing problem in health care: The prevalence of adults with chronic diseases of aging. Further to the point, 42% (98.2 million) of adults in the United States have two or more chronic diseases and cost the US healthcare system over $2 trillion per year.[i]
The AMBROSE Story
The story began in 2009, when Matt learned about the adult stem cells that reside in our fat (adipose tissue) from an investment colleague. Since that first conversation, he has done thousands of hours of research into the science, technology and unmet needs that could be addressed by adult stem cell therapy. As a result, Matt came to believe that the power of the mixed population of cells in our adipose tissue could improve symptoms, function and quality of life for a high percentage of patients with one or more chronic degenerative diseases. ([ii] [iii] [iv]) When these cells are clinical grade, they are called adipose-derived stem and regenerative cells (ADRCs).
Hence, AMBROSE Cell Therapy’s mission is to bring a new standard of safety and care for patients with complex chronic degenerative diseases.
Healthcare’s Most Vexing Problem
Seniors (65+) today see multiple physicians and, on average, take an estimated 7 different medications per day.[v] The aging population in the US, the majority of whom live with multiple chronic conditions, faces an irksome and costly complexity for patients, families and our society.
Chronic degenerative diseases have become a pandemic, overtaking infectious disease and injury as the leading cause of death. Compounding the issue, approximately 75 million people in the United States have multiple chronic conditions. These are defined as “conditions that last a year or more and require ongoing medical attention and/or limit activities of daily living.”
Multiple Chronic Conditions – Single Procedure
The AMBROSE medical team takes special care to develop safe, thoughtful and personalized treatment plans for our patients, making it possible to have more than one chronic condition addressed in a single cell therapy procedure. Harnessing the power of our own biology in this manner has the potential to make a remarkable improvement in outcomes for patients with one or more severe chronic diseases, as well as significantly reduce the emotional and financial burden of chronic diseases on the family and society.
Adipose-Derived Stem and Regenerative Cells (ADRCs)
Adipose tissue (body fat) is an attractive source of stem and regenerative cells due to its accessibility, abundance and potency compared to other tissue sources such as bone marrow, umbilical cord and placenta.
At AMBROSE, ADRCs are harvested, processed and reinjected at the bedside in a same-day procedure, and through multiple biologic activities, are used to improve symptoms, function and quality of life in a wide range of conditions. [vi] [vii] [viii]
Technology & Safety
AMBROSE processes harvested adipose tissue using the Celution® System. This fully automated, sterile and closed system is approved in over 40 countries and has been used in European, Japanese and FDA approved clinical trials as well thousands of elective procedures without a single reported cell-related adverse event.
ADRCs come from you. These cells have the innate purpose to rescue, repair and regenerate damaged tissue and organs with a remarkable safety profile, particularly as compared to drugs, surgery and devices.[ix]
[i] AK Parekh & MB Barton The Challenge of Multiple Comorbidity for the US Health Care System JAMA. 2010;303(13):1303-1304
[iii] A Nguyen, A et al Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 170e179
[iv] JK Fraser PhD and S Kesten MD Autologous Adipose Derived Regenerative Cells: A platform for therapeutic applications Advanced Wound Healing Surgical Technology International XXIX
[v] Guo et al Stromal vascular fraction: A regenerative reality? Part 2: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 180e188
[vi] JK Fraser PhD and S Kesten MD Autologous Adipose Derived Regenerative Cells: A platform for therapeutic applications Advanced Wound Healing Surgical Technology International XXIX
[vii] S. Amor Inflammation in neurodegenerative diseases Immunology, 129, 154–169
[viii] C. Franceschi and J. Campisi Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases J Gerontol A Biol Sci Med Sci 2014 June;69(S1): S4–S9
[xi] NM Toyserkani et al Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events STEM CELLS TRANSLATIONAL MEDICINE 2017; 00:00–00
AMBROSE Cell Therapy
The power of science, technology and your own biology.