Akita, S., et al. \u201cAutologous Adipose-Derived Regenerative Cells Are Effective for Chronic Intractable Radiation Injuries.\u201d Radiation Protection Dosimetry<\/em>, vol. 151, no. 4, 2012, pp. 656\u2013660., https:\/\/doi.org\/10.1093\/rpd\/ncs176.<\/p>\n Andjelkov, Katarina, and Zoran Maricic. \u201cPosterior Fourchette Fissure Resolution after Injection of Autologous Adipose-Derived Regenerative Cells.\u201d Obstetrics & Gynecology<\/em>, vol. 129, no. 3, 2017, pp. 497\u2013499., https:\/\/doi.org\/10.1097\/aog.0000000000001906.<\/p>\n Arkoulis, Nikolaos, et al. \u201cStem Cell Enriched Dermal Substitutes for the Treatment of Late Burn Contractures in Patients with Major Burns.\u201d Burns<\/em>, vol. 44, no. 3, 2018, pp. 724\u2013726., https:\/\/doi.org\/10.1016\/j.burns.2017.09.026.<\/p>\n Aronowitz, Joel A., and Joshua D.I. Ellenhorn. \u201cAdipose Stromal Vascular Fraction Isolation: A Head-to-Head Comparison of Four Commercial Cell Separation Systems.\u201d Plastic and Reconstructive Surgery<\/em>, vol. 132, 2013, p. 48., https:\/\/doi.org\/10.1097\/01.prs.0000435915.06075.66.<\/p>\n C. Calabrese, A. Kothari, S. Badylak, G. Di Taranto, M. Marcasciano, et al. Oncological safety of stromal vascular fraction enriched fat grafting in two-stage breast reconstruction after nipple sparing mastectomy: long-term results of a prospective study Eur Rev Med Pharmacol Sci. 2018 Aug;22(15):4768-4777. doi: 10.26355\/eurrev_201808_15610. PMID: 30070312.<\/p>\n Calcagni, Maurizio, et al. \u201cThe Novel Treatment of SVF-Enriched Fat Grafting for Painful End-Neuromas of Superficial Radial Nerve.\u201d Microsurgery<\/em>, vol. 38, no. 3, 2016, pp. 264\u2013269., https:\/\/doi.org\/10.1002\/micr.30122.<\/p>\n Cervelli, Valerio, et al. \u201cApplication of Enhanced Stromal Vascular Fraction and Fat Grafting Mixed with PRP in Post-Traumatic Lower Extremity Ulcers.\u201d Stem Cell Research<\/em>, vol. 6, no. 2, 2011, pp. 103\u2013111., https:\/\/doi.org\/10.1016\/j.scr.2010.11.003.<\/p>\n Che, Yiyang et al. \u201cTherapeutic Potential of Adipose-Derived Regenerative Cells for Ischemic Diseases.\u201d Cells vol. 14,5 343. 27 Feb. 2025.<\/p>\n Choi, Jae Young, et al. \u201cAdipose-Derived Regenerative Cell Injection Therapy for Postprostatectomy Incontinence: A Phase I Clinical Study.\u201d Yonsei Medical Journal<\/em>, vol. 57, no. 5, 2016, p. 1152., https:\/\/doi.org\/10.3349\/ymj.2016.57.5.1152.<\/p>\n Cremona, M et al. State of the Art in the Standardization of Stromal Vascular Fraction Processing. Biomolecules 2025, 15, 199.<\/p>\n Daumas, A., et al. \u201cLong-Term Follow-up after Autologous Adipose-Derived Stromal Vascular Fraction Injection into Fingers in Systemic Sclerosis Patients.\u201d Current Research in Translational Medicine<\/em>, vol. 65, no. 1, 2017, pp. 40\u201343., https:\/\/doi.org\/10.1016\/j.retram.2016.10.006.<\/p>\n F. Yotsumoto et al. Adipose tissue-derived regenerative cells improve implantation of fertilized eggs in thin endometrium Regen.Med. (2020) 15(7), 1891\u20131904<\/p>\n Foubert, P, et al. \u201c ADIPOSE-DERIVED REGENERATIVE CELLS PROMOTE PROLIFERATION OF CORNEAL EPITHELIAL CELL AND CORNEAL WOUND HEALING.\u201d Cytori Therapeutics<\/em>.<\/p>\n Foubert, Philippe, et al. \u201cAutologous Adipose-Derived Regenerative Cell Therapy Modulates Development of Hypertrophic Scarring in a Red Duroc Porcine Model.\u201d Stem Cell Research & Therapy<\/em>, vol. 8, no. 1, 2017, https:\/\/doi.org\/10.1186\/s13287-017-0704-1.<\/p>\n Foubert, Philippe, et al. \u201cPreclinical Assessment of Safety and Efficacy of Intravenous Delivery of Autologous Adipose-Derived Regenerative Cells (ADRCs) in the Treatment of Severe Thermal Burns Using a Porcine Model.\u201d Burns<\/em>, vol. 44, no. 6, 2018, pp. 1531\u20131542., https:\/\/doi.org\/10.1016\/j.burns.2018.05.006.<\/p>\n Fran\u00e7ois, P et al.<\/em> Inter-center comparison of good manufacturing practices-compliant stromal vascular fraction and proposal for release acceptance criteria: a review of 364 productions. Stem Cell Res Ther<\/em> 12<\/strong>, 373 (2021).<\/p>\n Fran\u00e7ois, Pauline, et al. \u201cDevelopment and Validation of a Fully GMP-Compliant Process for Manufacturing Stromal Vascular Fraction: A Cost-Effective Alternative to Automated Methods.\u201d Cells<\/em>, vol. 9, no. 10, 2020, p. 2158., https:\/\/doi.org\/10.3390\/cells9102158.<\/p>\n Fraser, John K., et al. \u201cThe Celution\u00aeSystem: Automated Processing of Adipose-Derived Regenerative Cells in a Functionally Closed System.\u201d Advances in Wound Care<\/em>, vol. 3, no. 1, 2014, pp. 38\u201345., https:\/\/doi.org\/10.1089\/wound.2012.0408.<\/p>\n Gentile, Pietro, et al. \u201cBreast Reconstruction with Enhanced Stromal Vascular Fraction Fat Grafting.\u201d Plastic and Reconstructive Surgery – Global Open<\/em>, vol. 3, no. 6, 2015, https:\/\/doi.org\/10.1097\/gox.0000000000000285.<\/p>\n Gentile, Pietro, et al. \u201cCharacteristics and Potentiality of Human Adipose-Derived Stem Cells (Hascs) Obtained from Enzymatic Digestion of Fat Graft.\u201d Cells<\/em>, vol. 8, no. 3, 2019, p. 282., https:\/\/doi.org\/10.3390\/cells8030282.<\/p>\n Gotoh, M, et al. \u201cLONG – TERM DURABILITY OF EFFICACY AND SAFETY OF REGENERATIVE TREATMENT OF MALE STRESS URINARY INCONTINENCE USING AUTOLOGOUS ADIPOSE – DERIVED REGENERATIVE CELLS.\u201d Urology Department, Nagoya University Graduate School of Medicine<\/em>.<\/p>\n Granel, Brigitte, et al. \u201cSafety, Tolerability and Potential Efficacy of Injection of Autologous Adipose-Derived Stromal Vascular Fraction in the Fingers of Patients with Systemic Sclerosis: An Open-Label Phase I Trial.\u201d Annals of the Rheumatic Diseases<\/em>, vol. 74, no. 12, 2014, pp. 2175\u20132182., https:\/\/doi.org\/10.1136\/annrheumdis-2014-205681.<\/p>\n Guillaume-Jugnot, Perrine, et al. \u201cAutologous Adipose-Derived Stromal Vascular Fraction in Patients with Systemic Sclerosis: 12-Month Follow-Up.\u201d Rheumatology<\/em>, vol. 55, no. 2, 2015, pp. 301\u2013306., https:\/\/doi.org\/10.1093\/rheumatology\/kev323<\/a>.<\/p>\n Guillo, L., Grimaud, F., Houser, F.\u00a0et al.<\/em>\u00a0Three-year outcome of local injection of autologous stromal vascular fraction cells and microfat in refractory perianal fistulas of Crohn\u2019s disease.\u00a0Stem Cell Res Ther<\/em>\u00a013<\/strong>, 67 (2022). https:\/\/doi.org\/10.1186\/s13287-022-02738-x<\/p>\n Haahr, Martha Kirstine, et al. \u201cA 12-Month Follow-up after a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial.\u201d Urology<\/em>, vol. 121, 2018, https:\/\/doi.org\/10.1016\/j.urology.2018.06.018.<\/p>\n Hao, Changning, et al. \u201cTherapeutic Angiogenesis by Autologous Adipose-Derived Regenerative Cells: Comparison with Bone Marrow Mononuclear Cells.\u201d American Journal of Physiology-Heart and Circulatory Physiology<\/em>, vol. 307, no. 6, 2014, https:\/\/doi.org\/10.1152\/ajpheart.00310.2014.<\/p>\n Saxer, F et al. Implantation of Stromal Vascular Fraction Progenitors at Bone Fracture Sites: From a Rat Model to a First-in-Man Study. Stem Cells. 2016 Dec;34(12):2956-2966. doi: 10.1002\/stem.2478. Epub 2016 Sep 16. PMID: 27538760.<\/p>\n Herold, C, et al. \u201cSupplementation of Fat Grafts with Adipose-Derived Regenerative Cells in Reconstructive Surgery.\u201d GMS German Plastic, Reconstructive and Aesthetic Surgery<\/em>, vol. 2, no. ISSN 2 1 93-7052, 2012.<\/p>\n Hirose, Yujiro, et al. \u201cComparison of Trophic Factors Secreted from Human Adipose-Derived Stromal Vascular Fraction with Those from Adipose-Derived Stromal\/Stem Cells in the Same Individuals.\u201d Cytotherapy<\/em>, vol. 20, no. 4, 2018, pp. 589\u2013591., https:\/\/doi.org\/10.1016\/j.jcyt.2018.02.001.<\/p>\n Itose, Masakatsu, et al. “Knee meniscus regeneration using autogenous injection of uncultured adipose tissue-derived regenerative cells.”\u00a0<\/span>Regenerative Therapy<\/i>\u00a0<\/span>21 (2022): 398-405.<\/p>\n J\u00f8rgensen, Mads Gustaf, et al. \u201cAdipose-Derived Regenerative Cells and Lipotransfer in Alleviating Breast Cancer-Related Lymphedema: An Open-Label Phase I Trial with 4\u2009Years of Follow-Up.\u201d Stem Cells Translational Medicine<\/em>, vol. 10, no. 6, 2021, pp. 844\u2013854., https:\/\/doi.org\/10.1002\/sctm.20-0394.<\/p>\n Kaita, Yasuhiko, et al. \u201cSufficient Therapeutic Effect of Cryopreserved Frozen Adipose-Derived Regenerative Cells on Burn Wounds.\u201d Regenerative Therapy<\/em>, vol. 10, 2019, pp. 92\u2013103., https:\/\/doi.org\/10.1016\/j.reth.2019.01.001.<\/p>\n Karaaltin, Mehmet Veli, et al. \u201cTreatment of \u2018En Coup De Sabre\u2019 Deformity with Adipose-Derived Regenerative Cell\u2013Enriched Fat Graft.\u201d Journal of Craniofacial Surgery<\/em>, vol. 23, no. 2, 2012, https:\/\/doi.org\/10.1097\/scs.0b013e3182418ce8.<\/p>\n Katagiri, Takeshi, et al. \u201cTherapeutic Angiogenesis Using Autologous Adipose-Derived Regenerative Cells in Patients with Critical Limb Ischaemia in Japan: A Clinical Pilot Study.\u201d Scientific Reports<\/em>, vol. 10, no. 1, 2020, https:\/\/doi.org\/10.1038\/s41598-020-73096-y.<\/p>\n Konstanty-Kalandyk J et al. Functional Recovery after Intramyocardial Injection of Adipose-Derived Stromal Cells Assessed by Cardiac Magnetic Resonance Imaging. Stem Cells Int. 2021 Apr 22;2021:5556800.<\/p>\n Kuka, Gorana et al. \u201cCell Enriched Autologous Fat Grafts to Follicular Niche Improves Hair Regrowth in Early Androgenetic Alopecia.\u201d Aesthetic surgery journal vol. 40,6 (2020): NP328-NP339.<\/p>\n Kuzma-Kozakiewicz, Magdalena, et al. \u201cIntraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts\u2019 Recommendations: Choosing Optimal Monitoring Tools.\u201d Stem Cells International<\/em>, vol. 2018, 2018, pp. 1\u201316., https:\/\/doi.org\/10.1155\/2018\/4392017.<\/p>\n Lasso, Jos\u00e9 M., et al. \u201cInjection Laryngoplasty Using Autologous Fat Enriched with Adipose-Derived Regenerative Stem Cells: A Safe Therapeutic Option for the Functional Reconstruction of the Glottal Gap after Unilateral Vocal Fold Paralysis.\u201d Stem Cells International<\/em>, vol. 2018, 2018, pp. 1\u201315., https:\/\/doi.org\/10.1155\/2018\/8917913.<\/p>\n Lathan, Rashida, et al. \u201cIschemic and Perfused Kidney Treated with Non-Cultured Adipose-Derived Regenerative Cells Increase the Immune and Regulatory Transcriptome.\u201d Transplantation<\/em>, vol. 104, no. S3, 2020, https:\/\/doi.org\/10.1097\/01.tp.0000699408.64700.70.<\/p>\n Maruya, Yasuhiro, et al. \u201cAutologous Adipose-Derived Stem Cell Sheets Enhance the Strength of\u00a0Intestinal Anastomosis.\u201d Regenerative Therapy<\/em>, vol. 7, 2017, pp. 24\u201333., https:\/\/doi.org\/10.1016\/j.reth.2017.06.004.<\/p>\n Mattei, Alexia, et al. \u201cAutologous Adipose-Derived Stromal Vascular Fraction and Scarred Vocal Folds: First Clinical Case Report.\u201d Stem Cell Research & Therapy<\/em>, vol. 9, no. 1, 2018, https:\/\/doi.org\/10.1186\/s13287-018-0842-0.<\/p>\n Mazini, Loubna, et al. \u201cOverview of Current Adipose-Derived Stem Cell (Adscs) Processing Involved in Therapeutic Advancements: Flow Chart and Regulation Updates before and after COVID-19.\u201d Stem Cell Research & Therapy<\/em>, vol. 12, no. 1, 2021, https:\/\/doi.org\/10.1186\/s13287-020-02006-w.<\/p>\n Narita S et al. Direct reprogramming of adult adipose-derived regenerative cells toward cardiomyocytes using six transcriptional factors. iScience. 2022 Jun 24;25(7):104651.<\/p>\n Onoi Y et al. Clinical use of autologous adipose-derived stromal vascular fraction cell injections for hip osteoarthritis. Regen Ther. 2023 Jun 15;24:94-102.<\/p>\n Perin EC et al. Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: The PRECISE Trial. Am Heart J. 2014 Jul;168(1):88-95.e2.<\/p>\n Perin, Emerson C., and James T. Willerson. \u201cBuying New Soul.\u201d Journal of the American College of Cardiology<\/em>, vol. 60, no. 21, 2012, pp. 2250\u20132251., https:\/\/doi.org\/10.1016\/j.jacc.2012.08.984.<\/p>\n Perez-Meza, David et al. \u201cHair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness.\u201d Stem cells and cloning : advances and applications vol. 10 1-10. 6 Jul. 2017.<\/p>\n Prins, Henk-Jan, et al. \u201cBone Regeneration Using the Freshly Isolated Autologous Stromal Vascular Fraction of Adipose Tissue in Combination with Calcium Phosphate Ceramics.\u201d Stem Cells Translational Medicine<\/em>, vol. 5, no. 10, 2016, pp. 1362\u20131374., https:\/\/doi.org\/10.5966\/sctm.2015-0369.<\/p>\n Sasaki, Gordon H. \u201cThe Safety and Efficacy of Cell-Assisted Fat Grafting to Traditional Fat Grafting in the Anterior Mid-Face: An Indirect Assessment by 3D Imaging.\u201d Aesthetic Plastic Surgery<\/em>, vol. 39, no. 6, 2015, pp. 833\u2013846., https:\/\/doi.org\/10.1007\/s00266-015-0533-5.<\/p>\n Saxer, Franziska, et al. \u201cImplantation of Stromal Vascular Fraction Progenitors at Bone Fracture Sites: From a Rat Model to a First-in-Man Study.\u201d Stem Cells<\/em>, vol. 34, no. 12, 2016, pp. 2956\u20132966., https:\/\/doi.org\/10.1002\/stem.2478.<\/p>\n Shimizu, Shinobu, et al. \u201cDesign of a Single-Arm Clinical Trial of Regenerative Therapy by Periurethral Injection of Adipose-Derived Regenerative Cells for Male Stress Urinary Incontinence in Japan: The ADRESU Study Protocol.\u201d BMC Urology<\/em>, vol. 17, no. 1, 2017, https:\/\/doi.org\/10.1186\/s12894-017-0282-7.<\/p>\n Shimizu, Yuuki, et al. \u201cAdipose-Derived Regenerative Cells for Cardiovascular Regeneration\u3000\u2013 A Novel Therapy for the Cardiac Conduction System \u2013.\u201d Circulation Journal<\/em>, vol. 79, no. 12, 2015, pp. 2555\u20132556., https:\/\/doi.org\/10.1253\/circj.cj-15-1106.<\/p>\n Shimizu, Yuuki, et al. \u201cRationale and Design of Therapeutic Angiogenesis by Cell Transplantation Using Adipose-Derived Regenerative Cells in Patients with Critical Limb Ischemia\u3000\u2015 Tact-ADRC Multicenter Trial \u2015.\u201d Circulation Reports<\/em>, vol. 2, no. 9, 2020, pp. 531\u2013535., https:\/\/doi.org\/10.1253\/circrep.cr-20-0055.<\/p>\n Shimizu, Yuuki, et al. \u201cTherapeutic Angiogenesis for Patients with No-Option Critical Limb Ischemia by Adipose-Derived Regenerative Cells: Tact-ADRC Multicenter Trial.\u201d Angiogenesis<\/em>, vol. 25, no. 4, 2022, pp. 535\u2013546., https:\/\/doi.org\/10.1007\/s10456-022-09844-7.<\/p>\n Shimizu, Yuuki, et al. \u201cTherapeutic Lymphangiogenesis with Implantation of Adipose\u2010Derived Regenerative Cells.\u201d Journal of the American Heart Association<\/em>, vol. 1, no. 4, 2012, https:\/\/doi.org\/10.1161\/jaha.112.000877.<\/p>\n Suzuki, Junya, et al. \u201cNo Influence on Tumor Growth by Intramuscular Injection of Adipose-Derived Regenerative Cells: Safety Evaluation of Therapeutic Angiogenesis with Cell Therapy.\u201d American Journal of Physiology-Heart and Circulatory Physiology<\/em>, vol. 320, no. 1, 2021, https:\/\/doi.org\/10.1152\/ajpheart.00564.2020.<\/p>\n Szczepanik, Elzbieta, et al. \u201cIntrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy.\u201d Stem Cells International<\/em>, vol. 2020, 2020, pp. 1\u201316., https:\/\/doi.org\/10.1155\/2020\/7104243.<\/p>\n Takamura M et al. Adipose-derived regenerative cells exert beneficial effects on systemic responses following myocardial ischemia\/reperfusion. Cardiol J. 2016;23(6):685-693.<\/p>\n Tsekouras, Anastasios, et al. \u201cAdipose-Derived Stem Cells for Breast Reconstruction after Breast Surgery \u2013 Preliminary Results.\u201d Case Reports in Plastic Surgery and Hand Surgery<\/em>, vol. 4, no. 1, 2017, pp. 35\u201341., https:\/\/doi.org\/10.1080\/23320885.2017.1316201.<\/p>\n Tsubosaka, Masanori, et al. \u201cThe Influence of Adipose-Derived Stromal Vascular Fraction Cells on the Treatment of Knee Osteoarthritis.\u201d BMC Musculoskeletal Disorders<\/em>, vol. 21, no. 207, 2020, https:\/\/doi.org\/10.21203\/rs.2.21422\/v1.<\/p>\n Yamaguchi, Shukuro, et al. \u201cAdipose-Derived Regenerative Cells as a Promising Therapy for Cardiovascular Diseases: an Overview.\u201d Nagoya J. Med. Sci<\/em>, vol. 84, 2022, pp. 208\u2013215.<\/p>\n Yoshimura, Kotaro, et al. \u201cCell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem\/Stromal Cells.\u201d Aesthetic Plastic Surgery<\/em>, vol. 44, no. 4, 2020, pp. 1258\u20131265., https:\/\/doi.org\/10.1007\/s00266-020-01819-7.<\/p>\n Yoshimura, Kotaro. \u201cCell-Assisted Lipotransfer and Therapeutic Use of Adipose Stem Cells Thereafter.\u201d Aesthetic Plastic Surgery<\/em>, vol. 44, no. 4, 2020, pp. 1266\u20131267., https:\/\/doi.org\/10.1007\/s00266-020-01781-4.<\/p>\n Zuk, Patricia A., et al. \u201cHuman Adipose Tissue Is a Source of Multipotent Stem Cells.\u201d Molecular Biology of the Cell<\/em>, vol. 13, no. 12, 2002, pp. 4279\u20134295., https:\/\/doi.org\/10.1091\/mbc.e02-02-0105.<\/p>\n Akita, Sadanori, et al. \u201cNoncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury.\u201d\u00a0Stem Cells International<\/em>, vol. 2010, 2010, pp. 1\u20138., doi:10.4061\/2010\/532704.<\/p>\n Albersen, Maarten, and Trinity J. Bivalacqua. \u201cRegenerative Medicine for Erectile Dysfunction Following Radical Prostatectomy: Are We Ready?\u201d\u00a0EBioMedicine<\/em>, vol. 5, 2016, pp. 28\u201329., doi:10.1016\/j.ebiom.2016.02.033.<\/p>\n Ashjian, Peter H., et al. \u201cIn Vitro Differentiation of Human Processed Lipoaspirate Cells into Early Neural Progenitors.\u201d\u00a0Plastic and Reconstructive Surgery<\/em>, vol. 111, no. 6, 2003, pp. 1922\u20131931., doi:10.1097\/01.prs.0000055043.62589.05.<\/p>\n Borowski, David W., et al. \u201cAdipose Tissue\u2013Derived Regenerative Cell\u2013Enhanced Lipofilling for Treatment of Cryptoglandular Fistulae-in-Ano.\u201d\u00a0Surgical Innovation<\/em>, vol. 22, no. 6, 2015, pp. 593\u2013600., doi:10.1177\/1553350615572656.<\/p>\n Foubert, Philippe, et al. \u201cAdipose-Derived Regenerative Cell Therapy for Burn Wound Healing: A Comparison of Two Delivery Methods.\u201d\u00a0Advances in Wound Care<\/em>, vol. 5, no. 7, 2016, pp. 288\u2013298., doi:10.1089\/wound.2015.0672.<\/p>\n Foubert, Philippe, et al. \u201cUncultured Adipose-Derived Regenerative Cells (Adrcs) Seeded in Collagen Scaffold Improves Dermal Regeneration, Enhancing Early Vascularization and Structural Organization Following Thermal Burns.\u201d\u00a0Burns<\/em>, vol. 41, no. 7, 2015, pp. 1504\u20131516., doi:10.1016\/j.burns.2015.05.004.<\/p>\n Fraser, John K, et al. \u201cPlasticity of Human Adipose Stem Cells toward Endothelial Cells and Cardiomyocytes.\u201d\u00a0Nature Clinical Practice Cardiovascular Medicine<\/em>, vol. 3, no. S1, 2006, doi:10.1038\/ncpcardio0444.<\/p>\n Fraser, John K., et al. \u201cFat Tissue: An Underappreciated Source of Stem Cells for Biotechnology.\u201d\u00a0Trends in Biotechnology<\/em>, vol. 24, no. 4, 2006, pp. 150\u2013154., doi:10.1016\/j.tibtech.2006.01.010.<\/p>\n Ganey, Timothy, et al. \u201cIntervertebral Disc Repair Using Adipose Tissue-Derived Stem and Regenerative Cells.\u201d\u00a0Spine<\/em>, vol. 34, no. 21, 2009, pp. 2297\u20132304., doi:10.1097\/brs.0b013e3181a54157.<\/p>\n Gentile, Pietro, et al. \u201cA Comparative Translational Study: The Combined Use of Enhanced Stromal Vascular Fraction and Platelet-Rich Plasma Improves Fat Grafting Maintenance in Breast Reconstruction.\u201d\u00a0Stem Cells Translational Medicine<\/em>, vol. 1, no. 4, 2012, pp. 341\u2013351., doi:10.5966\/sctm.2011-0065.<\/p>\n Haahr, Martha Kirstine, et al. \u201cSafety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial.\u201d\u00a0EBioMedicine<\/em>, vol. 5, 2016, pp. 204\u2013210., doi:10.1016\/j.ebiom.2016.01.024.<\/p>\n Henry, Timothy D., et al. \u201cThe Athena Trials: Autologous Adipose-Derived Regenerative Cells for Refractory Chronic Myocardial Ischemia with Left Ventricular Dysfunction.\u201d\u00a0Catheterization and Cardiovascular Interventions<\/em>, vol. 89, no. 2, 2016, pp. 169\u2013177., doi:10.1002\/ccd.26601.<\/p>\n Hirose, Yujiro et al. Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal\/stem cells in the same individuals Cytotherapy, Volume 20, Issue 4, 589 – 591<\/p>\n Houtgraaf, Jaco H., et al. \u201cFirst Experience in Humans Using Adipose Tissue\u2013Derived Regenerative Cells in the Treatment of Patients with St-Segment Elevation Myocardial Infarction.\u201d\u00a0Journal of the American College of Cardiology<\/em>, vol. 59, no. 5, 2012, pp. 539\u2013540., doi:10.1016\/j.jacc.2011.09.065.<\/p>\n Iddins, C.J., et al. \u201cCase Report: INDUSTRIAL X-RAY INJURY TREATED WITH NON-CULTURED AUTOLOGOUS ADIPOSE-DERIVED STROMALVASCULAR FRACTION (SVF).\u201d\u00a0Health Physics<\/em>, vol. 111, no. 2, 2016, pp. 112\u2013116., doi:10.1097\/hp.0000000000000483.<\/p>\n Kakudo, Natsuko, et al. \u201cAdipose-Derived Regenerative Cell (ADRC)-Enriched Fat Grafting: Optimal Cell Concentration and Effects on Grafted Fat Characteristics.\u201d\u00a0Journal of Translational Medicine<\/em>, vol. 11, no. 1, 2013, p. 254., doi:10.1186\/1479-5876-11-254.<\/p>\n Karaaltin, M, and S Baghaki. \u201cAdipose Derived Regenerative Cell Therapy f or Treating a Diabetic Wound: A Case Report.\u201d<\/p>\n Kesten, S, and J Fraser. \u201cAutologous Adipose Derived Regenerative Cells: A Platform for Therapeutic Applications.\u201d\u00a0Surgical Technology International XXIX<\/em>.<\/p>\n Kondo, Kazuhisa, et al. \u201cImplantation of Adipose-Derived Regenerative Cells Enhances Ischemia-Induced Angiogenesis.\u201d\u00a0Arteriosclerosis, Thrombosis, and Vascular Biology<\/em>, vol. 29, no. 1, 2009, pp. 61\u201366., doi:10.1161\/atvbaha.108.166496.<\/p>\n Lin, K., et al. \u201cCharacterization of Adipose Tissue-Derived Cells Isolated with the Celution\u2122 System.\u201d\u00a0Cytotherapy<\/em>, vol. 10, no. 4, 2008, pp. 417\u2013426., doi:10.1080\/14653240801982979.<\/p>\n Marino, G, et al. \u201cTherapy with Autologous Adipose-Derived Rigenerative Cells for the Care of Chronic Ulcer of Lower Limbs.\u201d\u00a0Seconda Universit\u00e0 Degli Studi Di Napoli<\/em>, 2012.<\/p>\n Marino, Gerardo, et al. \u201cTherapy with Autologous Adipose-Derived Regenerative Cells for the Care of Chronic Ulcer of Lower Limbs in Patients with Peripheral Arterial Disease.\u201d\u00a0Journal of Surgical Research<\/em>, vol. 185, no. 1, 2013, pp. 36\u201344., doi:10.1016\/j.jss.2013.05.024.<\/p>\n Nordberg, Rachel C., and Elizabeth G. Loboa. \u201cOur Fat Future: Translating Adipose Stem Cell Therapy.\u201d\u00a0Stem Cells Translational Medicine<\/em>, vol. 4, no. 9, 2015, pp. 974\u2013979., doi:10.5966\/sctm.2015-0071.<\/p>\n \u201cP406. Adipose Derived Regenerative Cells Injection as a Novel Method of Enterovesical Fistula Treatment in Crohn’s Disease: A Case Report.\u201d\u00a0Journal of Crohn’s and Colitis<\/em>, vol. 9, no. suppl 1, 2015, doi:10.1093\/ecco-jcc\/jju027.525.<\/p>\n Perez-Meza, David, et al. \u201cHair Follicle Growth by Stromal Vascular Fraction-Enhanced Adipose Transplantation in Baldness.\u201d\u00a0Stem Cells and Cloning: Advances and Applications<\/em>, Volume 10, 2017, pp. 1\u201310., doi:10.2147\/sccaa.s131431.<\/p>\n Sakai, Yoshio, et al. \u201cPhase I Clinical Study of Liver Regenerative Therapy for Cirrhosis by Intrahepatic Arterial Infusion of Freshly Isolated Autologous Adipose Tissue-Derived Stromal\/Stem (Regenerative) Cell.\u201d\u00a0Regenerative Therapy<\/em>, vol. 6, 2017, pp. 52\u201364., doi:10.1016\/j.reth.2016.12.001.<\/p>\n Sridhar, P, et al. \u201cAdipose-Derived Regenerative Cells for the Treatment of Patients with Non-Revascularisable Ischaemic Cardiomyopathy \u2013 the Precise Trial.\u201d\u00a0Interventional Cardiology Review<\/em>, vol. 7, no. 2, 2012, p. 77., doi:10.15420\/icr.2012.7.2.77.<\/p>\n Strem, B, et al. \u201cMultipotential Differentiation of Adipose Tissue-Derived Stem Cells.\u201d\u00a0Keio J Med<\/em>, 2005.<\/p>\n Suganuma, Seigo, et al. \u201cUncultured Adipose-Derived Regenerative Cells Promote Peripheral Nerve Regeneration.\u201d\u00a0Journal of Orthopaedic Science<\/em>, vol. 18, no. 1, 2013, pp. 145\u2013151., doi:10.1007\/s00776-012-0306-9.<\/p>\n Tiryaki, Tunc, et al. \u201cStaged Stem Cell-Enriched Tissue (Set) Injections for Soft Tissue Augmentation in Hostile Recipient Areas: A Preliminary Report.\u201d\u00a0Aesthetic Plastic Surgery<\/em>, vol. 35, no. 6, 2011, pp. 965\u2013971., doi:10.1007\/s00266-011-9716-x.<\/p>\n Toyserkani, Navid Mohamadpour, et al. \u201cCell-Assisted Lipotransfer Using Autologous Adipose-Derived Stromal Cells for Alleviation of Breast Cancer-Related Lymphedema.\u201d\u00a0Stem Cells Translational Medicine<\/em>, vol. 5, no. 7, 2016, pp. 857\u2013859., doi:10.5966\/sctm.2015-0357.<\/p>\n Toyserkani, Navid Mohamadpour, et al. \u201cTreatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.\u201d\u00a0Stem Cells Translational Medicine<\/em>, vol. 6, no. 8, 2017, pp. 1666\u20131672., doi:10.1002\/sctm.17-0037.<\/p>\n Wein, Alan J. \u201cRe: Regenerative Treatment of Male Stress Urinary Incontinence by Periurethral Injection of Autologous Adipose-Derived Regenerative Cells: 1-Year Outcomes in 11 Patients.\u201d\u00a0Journal of Urology<\/em>, vol. 195, no. 2, 2016, pp. 420\u2013420., doi:10.1016\/j.juro.2015.10.113.<\/p>\n Yokota, Naomasa, et al. \u201cClinical Results Following Intra-Articular Injection of Adipose-Derived Stromal Vascular Fraction Cells in Patients with Osteoarthritis of the Knee.\u201d\u00a0Regenerative Therapy<\/em>, vol. 6, 2017, pp. 108\u2013112., doi:10.1016\/j.reth.2017.04.002.<\/p>\n Yoshimoto, H, et al. \u201cEfficacy of Patients’ Own Adipose-Derived Regenerative Cells for Chronic Intractable Radiation Injuries.\u201d\u00a0Journal of Wound Technology<\/em>, Oct. 2010.<\/p>\n YOSHIMURA, KOTARO, et al. \u201cCell-Assisted Lipotransfer for Facial Lipoatrophy: Efficacy of Clinical Use of Adipose-Derived Stem Cells.\u201d\u00a0Dermatologic Surgery<\/em>, vol. 34, no. 9, 2008, pp. 1178\u20131185., doi:10.1111\/j.1524-4725.2008.34256.x.<\/p>\n Zuk, Patricia A., et al. \u201cMultilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies.\u201d\u00a0Tissue Engineering<\/em>, vol. 7, no. 2, 2001, pp. 211\u2013228., doi:10.1089\/107632701300062859.<\/p>\n [\/et_pb_text][et_pb_divider color=”RGBA(0,0,0,0)” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer CTA” _builder_version=”4.15.1″ _module_preset=”6ea0bfdb-1736-47ec-a731-c9b3bd89f568″ global_module=”317″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_blend=”multiply” width=”50%” max_width=”80%” custom_padding=”|||” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”3%” use_custom_width=”on” width_unit=”off” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” header_text_color=”#FFFFFF” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ parallax=”on” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/ambrosecelltherapy.com\/contact\/” button_text=”Learn More” button_alignment=”center” _builder_version=”4.16″ _module_preset=”default” background_layout=”dark” custom_margin=”30px||||false|false” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Cytori Citations Akita, S., et al. \u201cAutologous Adipose-Derived Regenerative Cells Are Effective for Chronic Intractable Radiation Injuries.\u201d Radiation Protection Dosimetry, vol. 151, no. 4, 2012, pp. 656\u2013660., https:\/\/doi.org\/10.1093\/rpd\/ncs176. Andjelkov, Katarina, and Zoran Maricic. \u201cPosterior Fourchette Fissure Resolution after Injection of Autologous Adipose-Derived Regenerative Cells.\u201d Obstetrics & Gynecology, vol. 129, no. 3, 2017, pp. 497\u2013499., https:\/\/doi.org\/10.1097\/aog.0000000000001906. […]<\/p>\n","protected":false},"author":9,"featured_media":8900,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":" Many sources of stem cells exist, not all of them are created equal. At AMBROSE, having examined these various sources and their functions, our interest is in the adult stem cells found in adipose tissue (fat).\u00a0<\/p> Adipose-derived stem and regenerative cells (ADRCs) are scientifically validated to be more accessible, abundant and potent than the stem cell populations from bone marrow and umbilical cord blood. They also have an advantaged mix of cell types to rescue, repair and regenerate damaged tissues, organs and the systems\u2014vascular, immune and endocrine (hormones)\u2014of our bodies. In addition, the factors of age-related declines in yield and potency that are found in the in the bone marrow are not observed in ADRCS. [i]<\/a> [ii]<\/a> [iii]<\/a><\/p> The term stem cell<\/em> first appeared in the scientific literature some 150 years ago in the works of the eminent German biologist Ernst Haeckel (Haeckel, 1868). Haeckel, a major supporter of Darwin\u2019s theory of evolution, drew a number of branching trees to represent the evolution of organisms by descent from common ancestors and called these trees \u2018\u2018Stammba \u0308 ume\u2019\u2019 (German for family trees or \u2018\u2018stem trees\u2019\u2019). In this context, Haeckel used the term \u2018\u2018Stammzelle\u2019\u2019 (German for stem cell) to describe these cells as the most basic cells in our body and from which all other cells are developed.<\/p> Embryonic stem cells (ESCs)\u2014of which there are between 50 and 150\u2014are developmental cells, meaning they develop into all of the cell lines of our body and those cells replicate. They are referred to as \u201ctotipotent stem cells,\u201d being the only cells capable of giving rise to all cell types necessary to develop an embryo into a fully formed body.<\/p> ESCs can develop into each of the more than 200 cell types of the adult\u00a0body\u00a0when given sufficient and necessary stimulation for a specific cell type, however ethical and medical concerns surround their use. Due to this they have been the subject of only a small number of human trials and are illegal to use in nearly all developed countries including the US.<\/p> The term \u201cadult stem cell\u201d is cause for some confusion, as these are the cells we are born with. Adults and infants alike possess the same \u201cadult\u201d stem cells. Thus, a more accurate and descriptive name for these cells might be \u201crepair cells,\u201d for this is their function in a fully developed body. Adult stem cells do not grow a new heart, brain, or bones\u2014they are purposed to keep what we have in good repair.<\/p> The history of adult stem cell research began in the 1950s, when researchers discovered that the bone marrow contains at least two kinds of stem cells. The first population, called hematopoietic stem cells (HSCs), forms all the types of blood cells in the body. HSCs make up approximately 99.9% of the stem cells in bone marrow and, as they are blood forming stem cells, they are used to treat blood cancers. Umbilical cord blood stem cells are also virtually all HSCs and have been approved for use to treat blood cancers as well.[iv]<\/a> There are stem cells in the umbilical cord tissue but as they are small in number per gram it is necessary to grow them out in a dish (culture).<\/p> The second population found in bone marrow is the mesenchymal stem cell (MSC).<\/p> The origin of the concept of a \u201cmesenchymal\u201d stem cell goes back to the pioneering experiments of Tavassoli and Crosby in the 1960s.[v]<\/a> In 1991, Prof. Arnold Caplan from Case-Western University named the MSC. [vi]<\/a> According to a Medline search, there are now over 49,000 published papers on MSCs and they have been used in over 700 clinical trials. In 2016, Dr. Caplan, in MSCs\u2014The Sentinel and Safe-Guards of Injury<\/em>[vii]<\/a>\u00a0 proposed renaming mesenchymal stem cells to \u201cmedicinal signaling cells\u201d due to their function of repairing through cell-to-cell communication or the \u201cparacrine effect.\u201d<\/p> There is more to fat than meets the eye. Whereas many researchers focus solely on the MSCs found in bone marrow, fat, umbilical cord, placenta, dental pulp and so on, in fat they are not unlike a lead singer in a band whose music is enriched and enhanced by backup singers and the other musicians. There are many other cell types in fat that work together, and we call these \u201cregenerative cells.\u201d<\/p> Adipose tissue functions as a protected reservoir of stem and regenerative cells throughout one\u2019s life. The studies using bone marrow mononuclear cells (BMNCs) for bone marrow found a steep drop-off in efficacy after the age of 62.[viii]<\/sup><\/a><\/p> Another advantage of fat as a cell source lies in the fact that there are up to 2,500 times more MSCs in a gram of adipose tissue vs a gram of bone marrow. [ix]<\/a><\/p> Fat-derived regenerative cells were first discovered in 1964 by Martin Rodbell who, using an enzyme and a centrifuge, successfully liberated a mixed population of cells from the adipose tissue of a mouse. Research on adult stem cells took a quantum leap forward in 2001, when Patricia Zuk PhD, Dr. Marc Hedrick and others working in the labs of UCLA, published a paper in Tissue Engineering discussing their discovery that mesenchymal stem cells (MSCs) reside alongside other regenerative cells in our fat<\/a>.[x]<\/a> With that a new era in medicine had begun.<\/p> Adult stem cells from different cells sources work for different indications including certain blood cancers for bone marrow and umbilical cord stem cells. Bone marrow stem cells have been shown to be most effective in orthopedic and cardiac cell therapy in middle-aged or younger patients due to the declining number and potency as we age. Conversely, ADRCs are accessible, abundant and potent later in life and hence hold the most promise for age-related degenerative diseases.<\/p> [i]<\/a> A Nguyen, A et al Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 170e179<\/p> [ii]<\/a>Guo et al Stromal vascular fraction: A regenerative reality? Part 2: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 180e188<\/p> [iii]<\/a>JK Fraser PhD and S Kesten MD Autologous Adipose Derived Regenerative Cells: A platform for therapeutic applications Advanced Wound Healing Surgical Technology International XXIX<\/p> [iv]<\/a>C Dessels et al Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape Stem Cells Translational Medicine April 2018<\/p> [v]<\/a>Tavassoli M, Crosby WH. Transplantation of marrow to extramedullary sites.\u00a0Science.\u00a01968;161:54\u201356.<\/p> [vi]<\/a> A. I. Caplan, Mesenchymal stem cells,\u00a0Journal of Orthopaedic Research, vol. 9, no. 5, pp. 641\u2013650, 1991<\/p> [vii]<\/a> A.I. Caplan MSCs \u2013 The Sentinel and Safe-Guards of Injury J. Cell. Physiol. 231: 1413\u20131416, 2016. \u00a02015 Wiley Periodicals, Inc<\/p> [viii]<\/a> J Willerson and E Perin Buying New Soul Journal of American College of Cardiology. 2012;60(21):2250-2251.<\/p>AMBROSE Cell Therapy<\/h1>\n
Your Right to Try<\/span><\/h3>\n
What is a Stem Cell?<\/strong><\/h3>
Embryonic Stem Cells<\/strong><\/h3>
Adult Stem Cells<\/strong><\/h3>
![\"\"](\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2018\/12\/Paracrine-Effect-600x176.jpg\")
<\/a><\/p>![\"\"](\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2018\/12\/MSCs-Adipose-vs.-Bone-Marrow-600x485.jpg\")
<\/a>MSCs are non-blood cell-making stem cells found in every tissue of our bodies. They make up a rare proportion of the\u00a0population in the bone marrow and can differentiate into bone, cartilage and fat cells. The early adult stem cell research focused on bone marrow source but one key problem arose: The quantity and potency of bone marrow stem cells decline with age as well as in the presence of chronic diseases.<\/p>Advantages of Adipose Tissue<\/strong><\/h3>
Different Cells, Different Jobs<\/strong><\/h3>