{"id":9374,"date":"2022-10-31T18:57:26","date_gmt":"2022-10-31T22:57:26","guid":{"rendered":"https:\/\/ambrosecelltherapy.com\/?page_id=9374"},"modified":"2022-11-02T11:48:19","modified_gmt":"2022-11-02T15:48:19","slug":"a-golden-era-of-cell-assisted-resilience","status":"publish","type":"page","link":"https:\/\/ambrosecelltherapy.com\/it\/a-golden-era-of-cell-assisted-resilience\/","title":{"rendered":"Un'era d'oro di resilienza assistita dalle cellule"},"content":{"rendered":"

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RJ’s Patient-Reported Outcome<\/h3>\n

Sports-related injuries, including concussions and whiplash, three failed shoulder surgeries, an unsuccessful right knee surgery, etc., retired RJ’s dream of playing Major League Baseball.<\/p>\n

In May 2022, he exercised his Right to Try AMBROSE Cell Therapy. Seven months later, he says, “Y’all (AMBROSE) changed my life.”<\/p>\n

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RJ’s Story
<\/strong>\"\"RJ played baseball, football, snowboarding, and golf growing up.<\/p>\n

“I had some concussions and whiplash from football and a few car accidents along the way.”<\/p>\n

RJ\u2019s shoulder issues started in high school. Initially, his doctor thought it was bicep tendonitis. “I had to take a month off every year. It never felt good.”<\/p>\n

One issue led to another. “When I was 17, I blew out my left knee running second base. After that, it would give out a lot.” The MRI showed his femur had lengthened, but it had never bothered RJ before the spill.<\/p>\n

RJ’s orthopedic surgeon shaved the femur down and cleaned up the knee.<\/em> “After the surgery, I did P.T. My knee felt better. I could run but couldn’t walk downhill or stairs.”<\/p>\n

Jumping ahead, before his AMBROSE Cell Therapy, RJ complained of left knee pain, clicking, and inability to walk downstairs or a hill. His right knee was symptomatic from compensating. “I could run, but it hurt,” he later said.<\/p>\n

Resuming RJ’s story: “I went back to playing baseball. My shoulder gave out after the first couple of days.”<\/p>\n

\"\"“Nothing showed up on my MRI and X-Ray, but I couldn’t move my arm. I went in for exploratory surgery. The surgeon found my rotator cuff and labrum were shredded.<\/p>\n

He repaired it, but then every season, it would give out”, RJ recounted.<\/p>\n

Doctors refer to the shoulder joint’s major tendons as the rotator cuff. Rotator cuff tears are common injuries. Advances in surgery have improved rotator cuff repairs. But failure rates remain high.<\/p>\n

\"\"Here, RJ’s massive rotator cuff tear (MRCT) caused disability and pain. An MRCT precipitates a Spiral of Degeneration<\/strong> beginning with inflammation, abnormal immune response, and lack of blood flow. That leads to programmed cell death (apoptosis), scarring, and degeneration.<\/p>\n

Unknown to many people and a key reason shoulder surgeries have such a high failure rate, the muscle around the rotator cuff shrinks, and the body replaces it with fatty tissue.<\/p>\n

When the tendon and muscle are finally reattached surgically to the shoulder bone, the weakened muscle can’t handle everyday stresses, and the area can be re-injured.<\/p>\n

“I tore my rotator cuff and labrum twice more, each followed by another surgery. Both surgeries failed. In between, I ripped a hamstring, broke some fingers, and fractured my hand while stealing second base,” he said.<\/p>\n

Cortisone injections, PRP, and physical therapy failed to bring lasting relief.<\/p>\n

In his senior year in college and after the last surgery, his baseball coach discouraged RJ from returning to the team.<\/p>\n

Allostatic Load and Anti-resilience.
<\/strong>Sterling and Eyer introduced the concept of allostasis\u00a0in 1988 as\u00a0stability through change. <\/em>From the Greek \u00e1llos, “other,” “different” + stasis, “standing still.” The researchers were imparting the concept of “remaining stable by being variable.”.<\/p>\n

Just as a sailor keeps his boat on an even keel despite choppy waters, the body’s biological systems maintain their equilibrium (homeostasis), despite<\/em> being put through stress.<\/p>\n

In contrast, allostatic Load<\/em>\u00a0is “the wear and tear on the body” accumulated from repeated or chronic\u00a0stress. (Bruce McEwen and Eliot Stellar 1993) Sailing across tall breaking waves over and over can cause irreparable damage.<\/p>\n

After RJ’s sports injuries, concussions, surgeries, and competitive stress, his physiologic systems were striking out. He descended from an elite baseball player to being told by his college coach that the disabled list was not a viable option.<\/p>\n

By age 23, RJ experienced debilitating symptoms beyond losing his ability to throw with his right arm and run the bases. He stopped bouncing back. In other words, allostatic load set in.<\/p>\n

Baseline
<\/strong>RJ’s constellation of wear and tear complaints included:<\/p>\n