{"id":7844,"date":"2019-04-23T15:56:24","date_gmt":"2019-04-23T15:56:24","guid":{"rendered":"https:\/\/ambrosecelltherapy.com\/?page_id=7844"},"modified":"2020-08-11T21:25:35","modified_gmt":"2020-08-12T01:25:35","slug":"mens-health","status":"publish","type":"page","link":"https:\/\/ambrosecelltherapy.com\/it\/mens-health\/","title":{"rendered":"Terapia cellulare AMBROSE per la salute degli uomini"},"content":{"rendered":"

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From ones\u2019 own fat, adipose-derived stem and regenerative cells (ADRCs) are a diverse population of cells that, through multiple activities, have the potential to help improve the urinary symptoms and pelvic pain that undermine the quality of life for men living with symptoms of an enlarged prostate, erectile dysfunction (ED) and Peyronie\u2019s disease.<\/p>\n

Chronic, low level systemic inflammation (inflammaging) is correlated with the major age-related degenerative diseases.[1]<\/a><\/sup> Chronic inflammation can affect any and all parts of the body. In fact, diseases with a local inflammatory causation and\/or systemic inflammation involvement often lead to other serious chronic conditions. People with Metabolic Syndrome (which involves cardiovascular, stroke, diabetes Type 2 and other risk factors including benign prostatic hyperplasia [BPH, or enlarged prostate] and ED) are well recognized to have their bodies in a proinflammatory state.[2]<\/a><\/sup> A high concentration of tumor necrosis factor alpha (TNF-alpha)\u2014proteins which promote inflammation\u2014has also been associated with Metabolic Syndrome.<\/p>\n

The Spiral of Degeneration<\/h3>\n

An inflammatory response can be triggered by a trauma, infection, environmental toxins, obesity, lifestyle choices (e.g. smoking), hereditary factors or a combination of those bad actors. The cells in the immune system (immune cells) are there to guard the body. When they sense the enemy, they send out troops of signaling molecules called proinflammatory \u201ccytokines\u201d to fight the bad actors off. This initial inflammation (acute) is essential for repairing the body, and is usually short-lived, disappearing once the healing process has taken place. When this process goes out of control, it is called an inflammatory-immune response, triggering chronic inflammation.<\/p>\n

It is chronic inflammation that begins a vicious degenerative process. An overactive inflammatory-immune response is tantamount to having a backseat driver who is chronically overreacting while \u201chelping\u201d you drive your car. This then leads to reduced blood flow (ischemia). Without good circulation, cells die off, scars form, tissues and organs degenerate. We call this the Spiral of Degeneration.<\/p>\n

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The Spiral is a very relevant framework with which to understand the detrimental process and effects of BPH and other issues affecting men\u2019s health. High blood pressure, diabetes, heart disease, chronic kidney disease and nerve injury from prostate surgery and radiation are some of the physical conditions that can cause ED. For conventional ED medications to work, the nervous system pathways must be intact, which is often not the case.<\/p>\n

In addition to underlying inflammatory-immune response, age-related impairment of blood supply to the lower urinary tract is important in the development of BPH and ED. Vascular damage may cause chronic ischemia and thus be a contributing factor in the disease progression of BPH and ED.[3]<\/a> [4]<\/a><\/sup> As explained previously, the ischemia leads to cell death and fibrosis, which can then result in ED, bladder dysfunction and Peyronie\u2019s disease.<\/p>\n

Process of Repair<\/h3>\n

ADRCs are akin to having your own, personalized fire department. They wait quietly for a sign of trouble\u2014inflammation\u2014and then home to that site to do their jobs.<\/p>\n

Through cell-to-cell communication known as paracrine signaling, ADRCs mobilize nearby cells to work more efficiently. In other words, ADRCs recruit repairmen at the site (resident stem cells) to get back on the job and do their part.<\/p>\n

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As an extended team, they first decrease inflammation and the overactive immune responses. Once the backseat driving diminishes they increase circulation with new blood vessel growth, prevent further cell death (apoptosis), decrease scar size and regenerate healthy tissue and nerves. This is how the body naturally heals, sometimes it just needs reinforcements.<\/p>\n

We call this the Process of Repair. It involves the multiple mechanisms of action that are needed to bring the systemic inflammation and immune system back to balance. Blood flow is restored, further programed cell death prevented and scar has been seen to be reversed.<\/p>\n

\"\"<\/a>Animal studies have shown that stem cell therapy for erectile dysfunction can regenerate nerves, muscle, and vascular tissue.[5]<\/a> [6]<\/a><\/sup> The safety of treatment with ones\u2019 own stem cells (autologous) has been established by Phase 1 studies.[7]<\/a><\/sup> Stem cell recipients have shown improvements in ED.[8]<\/a><\/sup><\/p>\n

Along with ED, urinary incontinence is a common consequence of treatment for prostate cancer. After establishing effectiveness in animal models, a study of local injection of ADRCs demonstrated safety and effectiveness in men that had urinary dysfunction after pelvic radiation.[9]<\/a><\/sup><\/p>\n

In Peyronie\u2019s disease, penile curvature results from fibrous, scar-like plaques forming in the soft tissues. Scar resolution is a well-documented effect of stem cells in animal models of the condition.[10]<\/a> [11]<\/a><\/sup> However the natural healing substances secreted by the stem cells and the cells\u2019 biochemical messaging effect on neighboring cells also play an important role.[12]<\/a><\/sup> Human studies have demonstrated that stem cell therapy can decrease and eliminate plaques in Peyronie\u2019s disease.[13]<\/a><\/sup> Many researchers consider treatment of Peyronie\u2019s with ADRCs to be a feasible, safe and potentially effective therapy.[14]<\/a><\/sup><\/p>\n

AMBROSE Cell Therapy for Men\u2019s Health<\/h3>\n

In summary, the Spiral of Degeneration is involved in the progression of BPH, ED and Peyronie\u2019s disease symptoms. However, men can now potentially benefit from AMBROSE Cell Therapy using ADRCs and the process of repair they initiate.<\/p>\n

Of critical importance, because these cells come from you and have the innate purpose to repair, they have a remarkable safety profile\u2014particularly as compared to drugs, surgery and devices.<\/p>\n

AMBROSE utilizes two biologic preparations in our protocols:<\/p>\n