{"id":7804,"date":"2019-04-16T18:01:11","date_gmt":"2019-04-16T18:01:11","guid":{"rendered":"https:\/\/ambrosecelltherapy.com\/?page_id=7804"},"modified":"2022-12-15T14:23:12","modified_gmt":"2022-12-15T18:23:12","slug":"inflammatory-bowel-diseases","status":"publish","type":"page","link":"https:\/\/ambrosecelltherapy.com\/de\/inflammatory-bowel-diseases\/","title":{"rendered":"AMBROSE Zelltherapie f\u00fcr entz\u00fcndliche Darmerkrankungen (IBD)"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Hero” _builder_version=”4.16″ background_image=”https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2018\/12\/Cover-Revision-e1544054347204.jpg” background_blend=”multiply” custom_padding=”|||” animation_style=”zoom” animation_intensity_zoom=”4%” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_blend=”multiply” max_width=”80%” custom_padding=”40px|||” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”3%” use_custom_width=”on” width_unit=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_post_title meta=”off” featured_image=”off” text_color=”light” _builder_version=”4.16″ title_font=”|700||on|||||” title_font_size=”40px” text_shadow_style=”preset2″ global_colors_info=”{}”][\/et_pb_post_title][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Main Content” _builder_version=”4.16″ custom_margin=”|||” custom_padding=”50px||30px|” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ animation_style=”fade” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.19.2″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Cell therapy for inflammatory bowel diseases harnesses the power of patients’ own adipose-derived stem and regenerative cells (ADRCs). This is a diverse population of cells that, through multiple activities, have the potential to help improve the symptoms, function and quality of life for patients living with conditions such as irritable bowel syndrome, ulcerative colitis, Celiac disease and Crohn\u2019s disease.<\/p>\n

These specialized cells are akin to having your own \u201cbiologic\u201d fire, rescue and repair service. They wait quietly for a sign of trouble\u2014inflammation\u2014and home to that site to do their jobs. The scientists researching adult stem cell therapy for inflammatory bowel diseases now widely recognize that ADRCs reduce inflammation and rebalance the immune system in initiating the process of repair.[1]<\/a> [2]<\/a> [3]<\/a> [4]<\/a> [5]<\/a><\/sup><\/p>\n

Inflammatory\u00a0bowel diseases\u00a0involve a chronic inflammation of some part of the digestive tract and sometimes can be associated with inflammatory arthritis. IBD-associated arthritis of the spine begins with subtle low back pain, especially in younger persons, and morning stiffness. It gets worse with prolonged sitting or standing and improves with moderate activity. It is more common in CD than in UC and is independent of gastrointestinal symptoms.<\/p>\n

Inflammatory-Immune Response<\/h3>\n

An inflammatory response can be triggered by a trauma, infection, environmental toxins, lifestyle choices (e.g. smoking), hereditary factors or a combination of those bad actors. This type of inflammation (acute) is essential for repairing the body, and is usually short-lived, disappearing once the healing process has taken place.<\/p>\n

There is another type of lingering inflammatory response which becomes chronic, and affects the entire body, becoming systemic. Systemic inflammation is a common factor in diseases of aging\u2014this covers a broad spectrum of severe, debilitating and, sometimes, life-threatening conditions.[6]<\/a><\/sup><\/p>\n

\"Inflammatory<\/p>\n

In the case of inflammatory bowel diseases, the chronic inflammation begins a vicious detrimental process. It recruits the immune system, which is there to fight infections and other disease processes, to assist healing. The cells in the immune system (immune cells) are there to guard the body. When they sense the enemy, they send out troops of pro-inflammatory molecules called \u201ccytokines\u201d to fight them off.\u00a0 When this process goes out of control, it is called an inflammatory-immune response.\u00a0 This response is tantamount to having a backseat driver who is chronically overreacting while \u201chelping\u201d you drive your car. It then leads to reduced blood flow (ischemia). Without good circulation, cells die off, scars form, tissues and organs degenerate. We call this the Spiral of Degeneration.<\/p>\n

\"Spiral<\/p>\n

Inflammatory bowel diseases involve chronic systemic inflammation perpetuating the Spiral. Because of this, many patients with IBD have various forms of arthritis including but not limited to osteoarthritis, psoriatic arthritis and so forth. Systemic inflammation can sometimes manifest in IBD-associated lung, heart, kidney, brain or liver diseases or even cancers.<\/p>\n

Process of Repair<\/h3>\n

Through a mechanism of cell-to cell communication known as the paracrine effect, ADRCs mobilize nearby cells to work more efficiently. They recruit the biologic fire, rescue and repair departments at the site\u2014resident stem cells\u2014to get back on the job and do their part.<\/p>\n

\"\"<\/p>\n

Recruiting additional \u201crepairmen\u201d at the site (resident stem cells) to get back on the job and do their part, ADRCs assemble an extended team and work first to decrease inflammation and the overactive immune responses. Once the backseat driving diminishes, they continue their work by increasing circulation with new blood vessel growth, preventing further cell death, addressing scar tissue and regenerating healthy tissue and nerves. This is how the body naturally heals, but if the insult from an acute or chronic condition is too great it needs help.<\/p>\n

We call this the Process of Repair. It involves the multiple mechanisms of action that are needed to bring the systemic inflammation and immune response back to balance.<\/p>\n

\"\"<\/p>\n

The process can extend to include the associated arthritic conditions as well as the organs affected by inflammatory bowel disease.<\/p>\n

Stem cells have regenerative and modulatory properties on the immune system, which leads to reduction of inflammation and healing of affected intestinal tissue.[7]<\/a><\/sup> Stem cells infused by vein have been shown in human studies to significantly lessened disease Crohn\u2019s Disease and Ulcerative Colitis, with one study reporting 68% of patients able to come off steroids after cell therapy. [8]<\/a> [9]<\/a><\/sup> Longstanding remission has been achieved in some patients.[10]<\/a><\/sup><\/p>\n

Stem cells are well known for wound healing, and in human studies, stem cells have been shown to close fistulae associated with Crohn\u2019s disease [11]<\/a> [12]<\/a> [13]<\/a> [14]<\/a> [15]<\/a><\/sup> as well as resolve inflammation in the fistula tract. [16]<\/a> [17]<\/a><\/sup><\/p>\n

AMBROSE Cell Therapy for Inflammatory Bowel Diseases<\/h3>\n

AMBROSE Cell Therapy represents a minimally invasive option to improve symptoms, function and quality of life for patients with inflammatory bowel diseases. Personalized treatment plans are developed for each patient, taking into account each individual\u2019s structural, biologic and medical status.<\/p>\n

Please contact us<\/a> for more information about treatment, candidacy and how to become a patient.<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.17.6″ text_font_size=”14px” text_line_height=”1.6em” custom_padding=”0px|||||” global_module=”7842″ global_colors_info=”{}”][\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_font_size=”80%” text_line_height=”1.5em” global_colors_info=”{}”]<\/p>\n

[1]<\/a>JK Fraser PhD and S. Kesten MD Autologous Adipose Derived Regenerative Cells: A platform for therapeutic applications Advanced Wound Healing Surgical Technology International XXIX<\/p>\n

[2]<\/a> A Nguyen, A et al Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 170e179<\/p>\n

[3]<\/a> Guo et al Stromal vascular fraction: A regenerative reality? Part 2: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 180e188<\/p>\n

[4]<\/a> F. De Francesco et al The role of adipose stem cells in inflammatory bowel disease: From biology to novel therapeutic strategies CANCER BIOLOGY & THERAPY 2016, VOL. 17, NO. 9, 889\u2013898<\/p>\n

[5]<\/a> Qui et al Systematic review with meta-analysis: the efficacy and safety of stem cell therapy for Crohn\u2019s disease Stem Cell Research & Therapy (2017) 8:136<\/p>\n

[6]<\/a> C. Franceschi and J. Campisi Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases J Gerontol A Biol Sci Med Sci 2014 June;69(S1): S4\u2013S9<\/p>\n

[7]<\/a> Dave M, Mehta K, Luther J, Baruah A, Dietz AB, Faubion WA. Mesenchymal Stem Cell Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Inflamm Bowel Dis. 2015;21(11):2696\u20132707<\/p>\n

[8]<\/a> Lazebnik LB, Konopliannikov AG, Kniazev OV, et al. [Use of allogeneic mesenchymal stem cells in the treatment of intestinal inflammatory diseases] Ter Arkh. 2010;82:38\u201343<\/p>\n

[9]<\/a> Forbes GM, Sturm MJ, Leong RW, et al. A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn\u2019s disease refractory to biologic therapy. Clin Gastroenterol Hepatol. 2014;12:64\u201371<\/p>\n

[10]<\/a> Liang J, Zhang H, Wang D, et al. Allogeneic mesenchymal stem cell transplantation in seven patients with refractory inflammatory bowel disease. Gut. 2012;61:468\u2013469<\/p>\n

[11]<\/a> Garcia-Olmo D, Garcia-Arranz M, Garcia LG, et al. Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn\u2019s disease: a new cell-based therapy. Int J Colorectal Dis. 2003;18:451\u2013454<\/p>\n

[12]<\/a> Garcia-Olmo D, Garcia-Arranz M, Herreros D, et al. A phase I clinical trial of the treatment of Crohn\u2019s fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum. 2005;48:1416\u20131423<\/p>\n

[13]<\/a> Garcia-Olmo D, Herreros D, Pascual I, et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum. 2009;52:79\u201386<\/p>\n

[14]<\/a> Cho YB, Lee WY, Park KJ, et al. Autologous adipose tissue-derived stem cells for the treatment of Crohn\u2019s fistula: a phase I clinical study. Cell Transplant. 2013;22:279\u2013285<\/p>\n

[15]<\/a> Lee WY, Park KJ, Cho YB, et al. Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn\u2019s fistula. Stem Cells. 2013;31:2575\u20132581<\/p>\n

[16]<\/a> Ciccocioppo R, Bernardo ME, Sgarella A, et al. Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn\u2019s disease. Gut. 2011;60:788\u2013798<\/p>\n

[17]<\/a> de la Portilla F, Alba F, Garcia-Olmo D, et al. Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn\u2019s disease: results from a multicenter phase I\/IIa clinical trial. Int J Colorectal Dis. 2013;28:313\u2013323<\/p>\n

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AMBROSE Cell Therapy<\/h1>\n

Your Right to Try<\/span><\/h3>\n

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Cell therapy for inflammatory bowel diseases harnesses the power of patients’ own adipose-derived stem and regenerative cells (ADRCs). This is a diverse population of cells that, through multiple activities, have the potential to help improve the symptoms, function and quality of life for patients living with conditions such as irritable bowel syndrome, ulcerative colitis, Celiac […]<\/p>\n","protected":false},"author":9,"featured_media":8001,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[mk_page_section layout_structure=\"half_right\" bg_image=\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2018\/11\/shutterstock_537411319.jpg\" bg_color=\"#1aa7aa\" min_height=\"500\" js_vertical_centered=\"true\" padding_top=\"0\" padding_bottom=\"0\"][vc_column][mk_fancy_title color=\"#ffffff\" size=\"37\" force_font_size=\"true\" size_phone=\"20\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" margin_bottom=\"30\" font_family=\"none\"]OUR BREAKTHROUGH IN STEM CELL THERAPY[\/mk_fancy_title][vc_column_text disable_pattern=\"false\" css=\".vc_custom_1541183975816{margin-bottom: 0px !important;}\"]We are leading the frontier to the innovation and discoveries. We are the first and only center in the US treating patients with our unique Ambrose Cell Thereapy.<\/span>[\/vc_column_text][\/vc_column][\/mk_page_section][vc_row][vc_column][mk_padding_divider size=\"80\"][\/vc_column][\/vc_row][vc_row][vc_column width=\"1\/6\"][\/vc_column][vc_column width=\"2\/3\"][mk_fancy_title color=\"#353535\" size=\"28\" force_font_size=\"true\" size_tablet=\"20\" size_phone=\"26\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" font_family=\"none\" align=\"center\"]what exactly is Ambrose Cell Therapy?[\/mk_fancy_title][vc_column_text align=\"center\" css=\".vc_custom_1541189399372{margin-bottom: 0px !important;}\"]Adult stem cell therapy is the process of isolating the stem and regenerative cells found in patients\u2019 own body fat and re-introducing them into damaged zones of the body and\/or systemically to address underlying factors of chronic, degenerative disease. Through minimally invasive adult stem cell therapy, \u00a0the body\u2019s own natural healing capabilities are put to work for each patient.<\/p>

To understand what stem cells are capable of first requires an understanding of a concept known as The Cycle of Disease. Although not all chronic disease is created equal with the same components, many share common denominators such as early inflammation, immune response, loss of blood supply, premature cell\/tissue death and resultant scarring.<\/p>

The treatment protocols of Okyanos are based on a thorough understanding of the multiple factors involved in each of the disease processes we treat. Stem cells have the unique advantage that they are able to address multiple aspects of the Cycle of Disease in a single treatment. Adult stem cells could be thought of as small physicians in the way that they go to work healing and repairing the body on a daily basis. Stem cells exist throughout our bodies and are responsible for healing our bumps and bruises and helping us recover from every day wear-and-tear.<\/p>

Restorative adult stem cells can be separated from your fat tissue and delivered to specific areas of the body in need of special attention. Because they have the capacity to detect issues\u00a0in the body which are causing pain or dysfunction, stem cells are able to respond and provide the correct \u201ctools\u201d needed for healing.[\/vc_column_text][mk_divider style=\"shadow_line\" margin_top=\"30\" margin_bottom=\"70\"][\/vc_column][vc_column width=\"1\/6\"][\/vc_column][\/vc_row][vc_row][vc_column width=\"1\/6\"][\/vc_column][vc_column width=\"2\/3\"][mk_fancy_title color=\"#353535\" size=\"28\" force_font_size=\"true\" size_tablet=\"20\" size_phone=\"26\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" font_family=\"none\" align=\"center\"]What sets Ambrose apart from other cell therapies?[\/mk_fancy_title][vc_column_text align=\"center\" css=\".vc_custom_1541185650115{margin-bottom: 0px !important;}\"]<\/p>

Our state-of-the-art facility is located in a government-regulated environment with routine oversight from regulators to ensure safety, and includes a Class C operating theater and Philips bi-plane cath lab for treating patients with cardiovascular disease and issues. Their team of doctors and medical staff include world-class physicians from each medical specialty including cardiology, orthopedics and neurology. These factors combine to make Ambrose a truly world-class cell therapy experience unlike anywhere else in the world that we are aware.<\/p>

[\/vc_column_text][\/vc_column][vc_column width=\"1\/6\"][\/vc_column][\/vc_row][vc_row][vc_column][mk_padding_divider][\/vc_column][\/vc_row][mk_page_section bg_color=\"#f8f8f8\" bg_repeat=\"no-repeat\" bg_stretch=\"true\" js_vertical_centered=\"true\" padding_top=\"60\" padding_bottom=\"60\" sidebar=\"sidebar-1\"][vc_column width=\"1\/6\"][\/vc_column][vc_column width=\"2\/3\"][mk_fancy_title color=\"#353535\" size=\"28\" force_font_size=\"true\" size_tablet=\"20\" size_phone=\"26\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" margin_top=\"20\" font_family=\"none\" align=\"center\"]Frequently Asked Questions[\/mk_fancy_title][vc_accordions][vc_accordion_tab icon=\"mk-moon-user-8\" title=\"Who is a candidate for stem cell therapy?\"][vc_column_text align=\"center\" css=\".vc_custom_1541185911237{margin-bottom: 0px !important;}\"]<\/p>

Determining if a patient is a good candidate for treatment is a highly individualized process for each patient at Okyanos. The medical team will review each individual\u2019s medical records to determine whether cell therapy is appropriate for the condition at hand.<\/p>

Requirements:<\/strong><\/p>