Further investigations in small animals, large animals, and humans demonstrated that adult cell therapy prevented, and in some instances reversed, kidney disease progression. Two pilot studies using cultured adipose-derived stem cells (ADSCs) employing different delivery methods stand out:<\/p>\n
- \n
- In 2018, a group from Chile published positive results with IV delivery of ADSCs to 6 renal failure patients,<\/li>\n
- In 2019, Mayo Clinic issued a report detailing safety and strong signals of efficacy after injecting ADSCs in the spinal canals (intrathecal) of a not dissimilar group of patients.<\/li>\n<\/ul>\n
In both cases, researchers reported reduced inflammation, lower serum creatinine levels, a reversal of fibrous scar (fibrosis), and improved blood flow. [2]<\/sup><\/a> [3]<\/sup><\/a> [4]<\/sup><\/a><\/p>\n
Spiral of Degeneration
<\/strong>Kidney failure follows a degenerative process similar to other chronic diseases.\u00a0 Trauma, environmental toxins, unhealthy lifestyle choices, hereditary factors, or a combination of these bad actors trigger an inflammatory response. Short-term inflammation (acute) is essential for repairing the body. This sort of inflammation is usually short-lived, disappearing once the healing process has taken place.<\/p>\nIt is chronic systemic inflammation that becomes a problem.[5]<\/sup><\/a>\u00a0\u00a0Systemic inflammation, or inflammaging, is a common factor in a broad spectrum of severe, debilitating, and, sometimes, life-threatening conditions, including renal failure.[6]<\/sup><\/a> [7]<\/sup><\/a><\/p>\n
![\"\"](\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2020\/10\/Chronic-Inflammation-Slide-600x338.jpg\")
In the case of degenerative diseases, chronic inflammation begins a vicious degenerative process. That inflammation recruits the immune system, which exists to fight infections and to assist in healing. The immune system is our body’s military police force.<\/p>\n![\"\"](\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2020\/10\/Cells-of-the-Immune-System1.jpg\")
<\/p>\nWhen immune cells sense the enemy, they send out troops of molecules called “cytokines” to fight them off.\u00a0 But the immune system can go out of control. An abnormal<\/em> inflammatory-immune response is like having a backseat driver overreacting while “helping” you drive your car.<\/p>\n
![\"\"](\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2020\/10\/New-Inflammatory-Immune-Response-600x294.jpg\")
<\/p>\nThe immune dysregulation then leads to reduced blood flow (ischemia). Without adequate circulation, cells die off, scars and fibrosis form, tissues, and organs degenerate.<\/p>\n
We call this the Spiral of Degeneration<\/p>\n
![\"Spiral](\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2019\/04\/degenerationKidneys-600x467.png\")
<\/p>\nLoss of kidney function corresponds with inflammation affecting the kidney’s filtering system and their small blood vessels. The early stages are usually without symptoms. As kidney function worsens, the number and severity of symptoms rear their ugly heads. Eventually, patients are required to purify their blood with dialysis, a substitute for the kidney’s normal function.<\/p>\n
Process of Repair
<\/strong>On the other side of the coin, ADRCs, through cell-to-cell communication, mobilize nearby cells to work more efficiently. This activity is called the paracrine effect.<\/p>\n![\"\"](\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2020\/10\/Cell-to-Cell-Slide1-600x338.jpg\")
<\/p>\nADRCs are like a highly specialized fire department. When reintroduced into the bloodstream, tissues, or organs, the firefighters home to inflammation sites and release hundreds of bioactive signaling molecules. These cytokines recruit resident cells, who act as repair engineers, at the site of injury or disease. The local cells further release cytokines that decrease inflammation and modulate the overactive immune responses. They also release growth factors that stimulate new blood vessel growth. More blood supply reverses programmed cell death and reduces scar size. The regeneration of tissue and nerves follows. \u00a0This process is how the body heals wounds \u2013 sometimes, it just needs reinforcements.<\/p>\n
We call this the Process of Repair.<\/p>\n
![\"\"](\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2019\/04\/Process-of-Repair-1-600x259.jpg\")
<\/p>\nThe factors in the Spiral are known to be involved with renal failure. The clinical trials for kidney disease show that the multiple repair mechanisms of the ADRCs can potentially reverse those factors. [8]<\/sup><\/a> [9]<\/sup><\/a> [10]<\/sup><\/a><\/p>\n
Summary
<\/strong>ADRCs have multiple attributes that are potentially helpful to kidney disease patients. Clinical-grade ADRCs can be prepared and delivered at the point of care.<\/p>\n![\"\"](\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2020\/10\/Patient-Process.jpg\")
<\/p>\nTo learn about more ADRCs, please see Why Adipose Tissue<\/a>.
To find out if you are a candidate for AMBROSE Cell Therapy, click here.<\/a><\/p>\n[\/et_pb_text][et_pb_text _builder_version=”4.6.6″ custom_padding=”0px|||||” global_module=”7842″][\/et_pb_text][et_pb_text _builder_version=”4.6.6″ text_font=”||||||||” text_font_size=”80%” text_line_height=”1.5em”][1]<\/a> Z Feng et al Fresh and cryopreserved, uncultured adipose tissue-derived stem and regenerative cells ameliorate ischemia\u2013reperfusion-induced acute kidney injury,\u00a0Nephrology Dialysis Transplantation<\/em>, Volume 25, Issue 12, 1 December 2010, Pages 3874\u20133884<\/p>\n
[2]<\/a> A Eirin et al Adipose tissue-derived mesenchymal stem cells improve revascularization outcomes to restore renal function in swine atherosclerotic renal artery stenosis Stem Cells. 2012 May; 30(5): 1030\u20131041<\/p>\n
[3]<\/a> A Abumoawad In a Phase 1a escalating clinical trial, autologous mesenchymal stem cell infusion for renovascular disease increases blood flow and the glomerular filtration rate while reducing inflammatory biomarkers and blood pressure Kidney International (2020) 97, 793\u2013804<\/p>\n
[4]<\/a> C Donizetti-Oliveira Adipose Tissue-Derived Stem Cell Treatment Prevents Renal Disease Progression Cell Transplantation, Vol. 21, pp. 1727\u20131741, 2012<\/p>\n
[5]<\/a> S. Amor Inflammation in neurodegenerative diseases Immunology, 129, 154\u2013169<\/p>\n
[6]<\/a> C. Franceschi and J. Campisi Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases J Gerontol A Biol Sci Med Sci 2014 June;69(S1): S4\u2013S9<\/p>\n
[7]<\/a> Suliman ME, Stenvinkel P. Contribution of Inflammation to Vascular Disease in Chronic Kidney Disease Patients. Saudi J Kidney Dis Transpl 2008;19:329-45<\/p>\n
[8]<\/a> A Nguyen, A et al Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 170e179<\/p>\n
[9]<\/a> Guo et al Stromal vascular fraction: A regenerative reality? Part 2: Current concepts and review of the literature Journal of Plastic, Reconstructive & Aesthetic Surgery (2016) 69, 180e188<\/p>\n
[10]<\/a> JK Fraser PhD and S Kesten MD Autologous Adipose Derived Regenerative Cells: A platform for therapeutic applications Advanced Wound Healing Surgical Technology International XXIX[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer CTA” _builder_version=”3.22.4″ background_image=”https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2018\/12\/Cover-Revision-e1544054347204.jpg” background_blend=”multiply” custom_padding=”25px|0px|25px|0px|true|false” animation_style=”zoom” animation_intensity_zoom=”4%” global_module=”317″][et_pb_row column_structure=”1_2,1_2″ _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” background_blend=”multiply” max_width=”80%” custom_padding=”|||” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”3%” use_custom_width=”on” width_unit=”off”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.1″ text_font=”Montserrat|700||on|||||” text_text_color=”#ffffff” text_letter_spacing=”3px” header_font=”|700|||||||” header_font_size=”36px” background_layout=”dark” custom_margin=”|||” animation_style=”slide” animation_direction=”bottom” locked=”off”]<\/p>\n
AMBROSE Cell Therapy<\/strong><\/h2>\n
Your Right to Try<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ parallax=”on” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/ambrosecelltherapy.com\/contact\/” button_text=”Learn More” _builder_version=”3.19″ custom_button=”on” button_text_color=”#ffffff” button_border_width=”3px” button_border_color=”#ffffff” button_border_radius=”9px” button_letter_spacing=”2px” button_font=”Montserrat|on||on|” button_icon=”%%36%%” animation_style=”slide” button_text_color_hover=”#ffffff” button_border_color_hover=”#ffffff” button_letter_spacing_hover=”2px” button_bg_color_hover=”rgba(0,0,0,0)” saved_tabs=”all” locked=”off” button_text_size__hover_enabled=”off” button_text_size__hover=”null” button_one_text_size__hover_enabled=”off” button_one_text_size__hover=”null” button_two_text_size__hover_enabled=”off” button_two_text_size__hover=”null” button_text_color__hover_enabled=”on” button_text_color__hover=”#ffffff” button_one_text_color__hover_enabled=”off” button_one_text_color__hover=”null” button_two_text_color__hover_enabled=”off” button_two_text_color__hover=”null” button_border_width__hover_enabled=”off” button_border_width__hover=”null” button_one_border_width__hover_enabled=”off” button_one_border_width__hover=”null” button_two_border_width__hover_enabled=”off” button_two_border_width__hover=”null” button_border_color__hover_enabled=”on” button_border_color__hover=”#ffffff” button_one_border_color__hover_enabled=”off” button_one_border_color__hover=”null” button_two_border_color__hover_enabled=”off” button_two_border_color__hover=”null” button_border_radius__hover_enabled=”off” button_border_radius__hover=”null” button_one_border_radius__hover_enabled=”off” button_one_border_radius__hover=”null” button_two_border_radius__hover_enabled=”off” button_two_border_radius__hover=”null” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”2px” button_one_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover=”null” button_two_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover=”null” button_bg_color__hover_enabled=”on” button_bg_color__hover=”rgba(0,0,0,0.21)” button_one_bg_color__hover_enabled=”off” button_one_bg_color__hover=”null” button_two_bg_color__hover_enabled=”off” button_two_bg_color__hover=”null”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
As is typical in a new research area, in 2010, a group of investigators did a mouse study to test the potential safety and effectiveness of adipose-derived stem and regenerative cells (ADRCs) to treat acute kidney disease. The results were positive: The study demonstrated that ADRC-therapy drastically reduced mortality, with 100% of the treated mice […]<\/p>\n","protected":false},"author":10,"featured_media":8004,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"
[mk_page_section layout_structure=\"half_right\" bg_image=\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2018\/11\/shutterstock_537411319.jpg\" bg_color=\"#1aa7aa\" min_height=\"500\" js_vertical_centered=\"true\" padding_top=\"0\" padding_bottom=\"0\"][vc_column][mk_fancy_title color=\"#ffffff\" size=\"37\" force_font_size=\"true\" size_phone=\"20\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" margin_bottom=\"30\" font_family=\"none\"]OUR BREAKTHROUGH IN STEM CELL THERAPY[\/mk_fancy_title][vc_column_text disable_pattern=\"false\" css=\".vc_custom_1541183975816{margin-bottom: 0px !important;}\"]We are leading the frontier to the innovation and discoveries. We are the first and only center in the US treating patients with our unique Ambrose Cell Thereapy.<\/span>[\/vc_column_text][\/vc_column][\/mk_page_section][vc_row][vc_column][mk_padding_divider size=\"80\"][\/vc_column][\/vc_row][vc_row][vc_column width=\"1\/6\"][\/vc_column][vc_column width=\"2\/3\"][mk_fancy_title color=\"#353535\" size=\"28\" force_font_size=\"true\" size_tablet=\"20\" size_phone=\"26\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" font_family=\"none\" align=\"center\"]what exactly is Ambrose Cell Therapy?[\/mk_fancy_title][vc_column_text align=\"center\" css=\".vc_custom_1541189399372{margin-bottom: 0px !important;}\"]Adult stem cell therapy is the process of isolating the stem and regenerative cells found in patients\u2019 own body fat and re-introducing them into damaged zones of the body and\/or systemically to address underlying factors of chronic, degenerative disease. Through minimally invasive adult stem cell therapy, \u00a0the body\u2019s own natural healing capabilities are put to work for each patient.<\/p>
To understand what stem cells are capable of first requires an understanding of a concept known as The Cycle of Disease. Although not all chronic disease is created equal with the same components, many share common denominators such as early inflammation, immune response, loss of blood supply, premature cell\/tissue death and resultant scarring.<\/p>
The treatment protocols of Okyanos are based on a thorough understanding of the multiple factors involved in each of the disease processes we treat. Stem cells have the unique advantage that they are able to address multiple aspects of the Cycle of Disease in a single treatment. Adult stem cells could be thought of as small physicians in the way that they go to work healing and repairing the body on a daily basis. Stem cells exist throughout our bodies and are responsible for healing our bumps and bruises and helping us recover from every day wear-and-tear.<\/p>
Restorative adult stem cells can be separated from your fat tissue and delivered to specific areas of the body in need of special attention. Because they have the capacity to detect issues\u00a0in the body which are causing pain or dysfunction, stem cells are able to respond and provide the correct \u201ctools\u201d needed for healing.[\/vc_column_text][mk_divider style=\"shadow_line\" margin_top=\"30\" margin_bottom=\"70\"][\/vc_column][vc_column width=\"1\/6\"][\/vc_column][\/vc_row][vc_row][vc_column width=\"1\/6\"][\/vc_column][vc_column width=\"2\/3\"][mk_fancy_title color=\"#353535\" size=\"28\" force_font_size=\"true\" size_tablet=\"20\" size_phone=\"26\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" font_family=\"none\" align=\"center\"]What sets Ambrose apart from other cell therapies?[\/mk_fancy_title][vc_column_text align=\"center\" css=\".vc_custom_1541185650115{margin-bottom: 0px !important;}\"]<\/p>
Our state-of-the-art facility is located in a government-regulated environment with routine oversight from regulators to ensure safety, and includes a Class C operating theater and Philips bi-plane cath lab for treating patients with cardiovascular disease and issues. Their team of doctors and medical staff include world-class physicians from each medical specialty including cardiology, orthopedics and neurology. These factors combine to make Ambrose a truly world-class cell therapy experience unlike anywhere else in the world that we are aware.<\/p>
[\/vc_column_text][\/vc_column][vc_column width=\"1\/6\"][\/vc_column][\/vc_row][vc_row][vc_column][mk_padding_divider][\/vc_column][\/vc_row][mk_page_section bg_color=\"#f8f8f8\" bg_repeat=\"no-repeat\" bg_stretch=\"true\" js_vertical_centered=\"true\" padding_top=\"60\" padding_bottom=\"60\" sidebar=\"sidebar-1\"][vc_column width=\"1\/6\"][\/vc_column][vc_column width=\"2\/3\"][mk_fancy_title color=\"#353535\" size=\"28\" force_font_size=\"true\" size_tablet=\"20\" size_phone=\"26\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" margin_top=\"20\" font_family=\"none\" align=\"center\"]Frequently Asked Questions[\/mk_fancy_title][vc_accordions][vc_accordion_tab icon=\"mk-moon-user-8\" title=\"Who is a candidate for stem cell therapy?\"][vc_column_text align=\"center\" css=\".vc_custom_1541185911237{margin-bottom: 0px !important;}\"]<\/p>
Determining if a patient is a good candidate for treatment is a highly individualized process for each patient at Okyanos. The medical team will review each individual\u2019s medical records to determine whether cell therapy is appropriate for the condition at hand.<\/p>
Requirements:<\/strong><\/p>
- Must not have undergone cancer treatment in the past 6 months<\/li>
- Must be able to lay flat for the procedure<\/li>
- Medical records must indicate the ability to safely undergo fat harvesting (a minor liposuction procedure)<\/li>
- A sufficient BMI for fat harvesting<\/li><\/ul>
[\/vc_column_text][\/vc_accordion_tab][vc_accordion_tab icon=\"mk-icon-clock-o\" title=\"How long does stem cell therapy take?\"][\/vc_accordion_tab][vc_accordion_tab icon=\"mk-moon-stats-up\" title=\"What are the potential benefits for patients with chronic conditions?\"][vc_column_text align=\"center\" css=\".vc_custom_1541184868898{margin-bottom: 0px !important;}\"]<\/p>
The stem and regenerative cells stored in your body fat could be likened to small \u201cphysicians\u201d who diagnose and correct individual areas of the body in need of special attention. Because these cells have the capacity to detect changes in the body which are causing pain or dysfunction, they respond and communicate with the body\u2019s needs to provide the correct tools needed for healing. These adult stem cells are commonly referred to as \u201crepair cells,\u201d their primary functions being:<\/p>
- Accelerated tissue repair<\/li>
- Stimulated tissue regeneration<\/li>
- Decreased inflammation<\/li>
- Prevention of continued premature cell death<\/li>
- Creation of new blood vessels<\/li><\/ul>
Re-introducing your own stem cells into an injured area of the body\u2014be it a joint, damaged heart or other tissue\u2014can stimulate new blood flow in these areas while reducing inflammation. Cell therapy enables the stem cells in your body to do their job as tiny little \u201cphysicians\u201d in the process of healing. Learn more about the potential benefits of cell therapy for chronic conditions\u00a0here<\/a>.<\/p>
[\/vc_column_text][\/vc_accordion_tab][vc_accordion_tab icon=\"mk-icon-exclamation-circle\" title=\"What are the risks?\"][vc_column_text align=\"center\" css=\".vc_custom_1541184924750{margin-bottom: 0px !important;}\"]<\/p>
The risks are minimal. Okyanos therapies have been shown to be safe and efficacious in scientific and\/or medical literature for the conditions we treat, and there have been zero reports of cell-related adverse effects\u00a0 using a patient\u2019s own adipose-derived stem and regenerative cells (ADRCs). Further, because these cells are autologous (a patient\u2019s own) the risk of cell rejection is eliminated. For cardiac patients, the risk of bleeding is very low and the procedure is similar to having an angioplasty.<\/p>
[\/vc_column_text][\/vc_accordion_tab][vc_accordion_tab icon=\"mk-icon-question-circle\" title=\"Why adispose (fat) stem cells, not bone marrow?\"][vc_column_text align=\"center\" css=\".vc_custom_1541184924750{margin-bottom: 0px !important;}\"]<\/p>
The risks are minimal. Okyanos therapies have been shown to be safe and efficacious in scientific and\/or medical literature for the conditions we treat, and there have been zero reports of cell-related adverse effects\u00a0 using a patient\u2019s own adipose-derived stem and regenerative cells (ADRCs). Further, because these cells are autologous (a patient\u2019s own) the risk of cell rejection is eliminated. For cardiac patients, the risk of bleeding is very low and the procedure is similar to having an angioplasty.<\/p>
[\/vc_column_text][\/vc_accordion_tab][vc_accordion_tab icon=\"mk-icon-money\" title=\"Do you offer financing?\"][vc_column_text align=\"center\" css=\".vc_custom_1541185517582{margin-bottom: 0px !important;}\"]<\/p>
We ask that you call and provide us with information about your specific condition so that we may advise you on pricing. Although cost is an important factor, it isn\u2019t the only factor. Allow us to learn about you so we can determine if our treatment is right for you.<\/p>
We can refer you to several financing sources that may work for you. Please visit our\u00a0Financing page<\/a>\u00a0to learn more.<\/p>
[\/vc_column_text][\/vc_accordion_tab][vc_accordion_tab icon=\"mk-icon-money\" title=\"Do you offer financing?\"][vc_column_text align=\"center\" css=\".vc_custom_1541185517582{margin-bottom: 0px !important;}\"]<\/p>
We ask that you call and provide us with information about your specific condition so that we may advise you on pricing. Although cost is an important factor, it isn\u2019t the only factor. Allow us to learn about you so we can determine if our treatment is right for you.<\/p>