{"id":8242,"date":"2020-01-24T18:16:38","date_gmt":"2020-01-24T18:16:38","guid":{"rendered":"https:\/\/ambrosecelltherapy.com\/?page_id=8242"},"modified":"2020-08-11T21:26:26","modified_gmt":"2020-08-12T01:26:26","slug":"rationale-for-spinal-cord-injury-cell-therapy","status":"publish","type":"page","link":"https:\/\/ambrosecelltherapy.com\/ar\/rationale-for-spinal-cord-injury-cell-therapy\/","title":{"rendered":"\u0627\u0644\u0623\u0633\u0627\u0633 \u0627\u0644\u0645\u0646\u0637\u0642\u064a \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062e\u0644\u0627\u064a\u0627 \u0625\u0635\u0627\u0628\u0627\u062a \u0627\u0644\u062d\u0628\u0644 \u0627\u0644\u0634\u0648\u0643\u064a"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Hero” _builder_version=”3.29.3″ background_image=”https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2018\/12\/Cover-Revision-e1544054347204.jpg” background_blend=”multiply” custom_padding=”|||” animation_style=”zoom” animation_intensity_zoom=”4%”][et_pb_row _builder_version=”3.25″ background_blend=”multiply” max_width=”80%” custom_padding=”40px|||” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”3%” use_custom_width=”on” width_unit=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_post_title meta=”off” featured_image=”off” text_color=”light” _builder_version=”3.29.3″ title_font=”|700||on|||||” title_font_size=”40px” text_shadow_style=”preset2″][\/et_pb_post_title][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Main Content” _builder_version=”3.22.3″ custom_margin=”|||” custom_padding=”50px||30px|”][et_pb_row _builder_version=”3.25″ animation_style=”fade”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.1″ hover_enabled=”0″]<\/p>\n

In 2006, a group of researchers from Korea and Canada wrote a review paper covering a number of stem cell studies in small and large animals for spinal cord injury (SCI). They noted the potential for adult stem cell therapy to improve function in SCI patients. As the research has progressed, human trials using adult stem cells have added support to that thesis. [1]<\/a> [2]<\/a> [3]<\/a> [4]<\/a><\/sup><\/p>\n

Fast forward to late 2019, Mayo Clinic published a case report, in which stem cells from a patient\u2019s fat (adipose-stem cells or ASCs) were delivered via the spinal canal (intrathecally) to an SCI patient. The one-time treatment resulted in a remarkable improvement in function and symptoms. Notwithstanding the fact that the report was for a single patient (selected from a larger trial), the author referred to the promise this \u201csuper-responder\u201d represents for those suffering similarly. [5]<\/a><\/sup><\/p>\n

From another angle, positive cell therapy studies or case reports have also been published that relate to some of the follow-on effects that can result from the injury to the spinal cord or subsequent surgeries. The reported benefits include, but are not limited to, reduction of scar and neuropathic pain as well as improvement in bowel, bladder and sexual functions. [6]<\/a> [7]<\/a><\/sup><\/p>\n

ADRCs<\/h3>\n

AMBROSE accesses the mixed population of stem and regenerative cells in a patient\u2019s fat (adipose tissue). This cell preparation, when clinical grade, is called adipose-derived stem and regenerative cells (ADRCs). [8]<\/a><\/sup><\/p>\n

\"Adipose<\/p>\n

ADRCs are akin to having your own, personalized fire department. They wait quietly for a sign of trouble \u2013 inflammation \u2013 and then home to that site to do their jobs. When they arrive on the scene, they blanket a diseased tissue or organ with hundreds of biologically active molecules that promote cellular, nerve and tissue repair. [9]<\/a><\/sup> More on the process of repair in a moment; first some basics:<\/p>\n

Spinal Cord Injury<\/h3>\n

The brain and spinal cord comprise the central nervous system. Sensory and motor nerve impulses travel to and from the brain along the nerve fibers that make up the spinal cord. This long tube-like structure runs from the base of the brain to the lower back (lumbar) region. These bundled nerve fibers are protectively surrounded by the bones of the vertebra. Injury to a vertebral bone can tear or compress the spinal cord, which can impact sensation and function.<\/p>\n

\"\"<\/p>\n

Different degrees of paralysis depend on the location and severity of the damage. Loss of nerve cells (neurons) may also affect talking, breathing and memory in various ways and at different time points. This all depends on the affected areas of the CNS, the degree of neuroinflammation and rate of degeneration that follows.<\/p>\n

SCI After-Effects<\/h3>\n

The after-effects of traumatic spinal cord injury (SCI) are clearly significant and often catastrophic. While what the observer sees is the paralysis for those most affected, it can also mean pain as well as a host of other less obvious disabilities. In other words, the consequences of SCI are not confined to the spinal cord; other parts and systems of the body are typically involved.<\/p>\n

Spiral of Degeneration<\/h3>\n

The trauma from the impact on the spinal cord leads to neuroinflammation, defined as chronic inflammation in the central nervous system (CNS). This causes the immune system to overreact (inflammatory-immune response) to protect the nerves. Unfortunately, this is like a backseat driver thinking they are helping you but instead they cause you to get in a car wreck. This response leads to poor blood flow (ischemia) in the spinal cord. Our CNS needs blood flow to bring oxygen and nutrients to it to keep it healthy. Without it, the cells of the myelin sheathing, which insulate the nerves, die off, scar forms and the CNS stops functioning normally. We call this the Spiral of Degeneration.<\/p>\n

\"Spiral<\/p>\n

Process of Repair<\/h3>\n

On the other side of the coin, ADRCs, through cell-to-cell communication, mobilize nearby cells to go back to work and do their jobs of repair. This is called the \u201cparacrine effect\u201d.<\/p>\n

\"\"<\/p>\n

ADRCs first decrease inflammation and the overactive immune response. Once the backseat driving has diminished, they increase circulation with new blood vessel growth, prevent further programmed cell death, decrease scar size \u2013 or in the case of SCI remyelinate the nerves – and regenerate. We call this the Process of Repair.<\/p>\n

\"AMBROSE<\/p>\n

Neurotrophic Factors<\/h3>\n

Very relevant and important to SCI repair are a family of biomolecules that could be thought of as an organic fertilizer for our nerves. These are called \u201cNeurotrophic factors (NTFs)\u201d. Neuro relating to nerve and trophic is from Ancient Greek \u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03cc\u03c2 (trophik\u00f3s) meaning “pertaining to food or nourishment”. NTFs support the growth, survival, and differentiation of both developing and mature nerve cells (neurons), including new myelin sheathing (remyelination).<\/p>\n

It has been documented that adipose-derived stem cells (ADSCs) specifically release brain-derived neurotrophic growth factor (BDNF). BDNF promotes nerve healing, remyelination and axon growth. [10]<\/a> [11]<\/a><\/sup><\/p>\n

\"Brain<\/p>\n

To summarize, ADRCs have a range of potential activities including but not limited to:
\u2022 Homing toward scarred (lesioned) areas
\u2022 Decreasing spinal cord inflammation
\u2022 Differentiating into neurons (neurogenesis)
\u2022 Promoting nervous tissue maintenance and repair
\u2022 Reducing disease severity
\u2022 Decreasing demyelination
\u2022 Remyelination [12]<\/a> [13]<\/a> [14]<\/a><\/sup><\/p>\n

\"\"<\/p>\n

Patient Expectations<\/h3>\n

The ASIA Impairment Scale (AIS) ranges from A to E, where A is a complete SCI and E denotes normal sensory and motor function. A patient\u2019s AISA score is a monitoring factor in the expectations one should have for improvement. Said another way, the goal of AMBROSE Cell Therapy is improvement in symptoms, function and quality of life over the baseline AIS score.<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.1″ custom_padding=”0px|||||” global_module=”7842″][\/et_pb_text][et_pb_text _builder_version=”4.1″ text_font=”||||||||” text_font_size=”80%” text_line_height=”1.5em”]<\/p>\n

[1]<\/a> B.G. Kim et al Stem Cell-Based Cell Therapy for Spinal Cord Injury Cell Transplantation<\/em>, 16(4), 355\u2013364 2007<\/p>\n

[2]<\/a> Mendon\u00e7a et al. Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury Stem Cell Research & Therapy 2014, 5:126<\/p>\n

[3]<\/a> JW Hur et al. Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial. J Spinal Cord Med<\/em>. 2016;39(6):655\u2013664.<\/p>\n

[4]<\/a> Y Kim et al. Antioxidant and anti-inflammatory effects of intravenously injected adipose derived mesenchymal stem cells in dogs with acute spinal cord injury Stem Cell Research & Therapy (2015) 6:229<\/p>\n

[6]<\/a> M Bydon et al. CELLTOP Clinical Trial: First Report From a Phase 1 Trial of Autologous Adipose Tissue\u2013Derived Mesenchymal Stem Cells in the Treatment of Paralysis Due to Traumatic Spinal Cord Injury Mayo Clinic Proceedings, Volume 0, Issue 0<\/p>\n

[6]<\/a> GL Nanninga et al. Lipofilling may induce nerve regeneration after previous traumatic injury: a clinical case with remarkable outcome Eur J Plast Surg (2016) 39:383\u2013386<\/p>\n

[7]<\/a> Fat Grafting in Burn Scar Alleviates Neuropathic Pain via Anti-Inflammation Effect in Scar and Spinal Cord PLOS ONE September 14, 2015<\/p>\n

[8]<\/a> JK Fraser PhD and S. Kesten MD Autologous Adipose Derived Regenerative Cells: A platform for therapeutic applications Advanced Wound Healing Surgical Technology International XXIX<\/p>\n

[9]<\/a> A Caplan PhD MSCs: The Sentinel and Safe-Guards of Injury J. Cell. Physiol. 231: 1413\u20131416, 2016.<\/p>\n

[10]<\/a> Razavi, Shahnaz et al. \u201cNeurotrophic Factors and Their Effects in the Treatment of Multiple Sclerosis.\u201d Advanced Biomedical Research<\/em> 4 (2015): 53. PMC. Web. 28 Sept. 2018.<\/p>\n

[11]<\/a> T Lopatina et al. (2011) Adipose-Derived Stem Cells Stimulate Regeneration of Peripheral Nerves: BDNF Secreted by These Cells Promotes Nerve Healing and Axon Growth De Novo. PLoS ONE 6(3): e178991<\/p>\n

[12]<\/a>AJ Mothe and CH Tator Advances in stem cell therapy for spinal cord injury J Clin Invest. 2012;122(11) :3824-3834<\/p>\n

[13]<\/a> Azim Hedayatpour, Ph.D. et al Promotion of remyelination by adipose mesenchymal stem cell transplantation in a cuprizone model of multiple sclerosis. Cell J. 2013; 15(2): 142-151.<\/p>\n

[14]<\/a> S. Seigo et al, Uncultured adipose-derived regenerative cells promote peripheral nerve regeneration, Journal of Orthopaedic Science, Volume 18, Issue 1,2013, Pages 145-151<\/p>\n

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AMBROSE Cell Therapy<\/strong><\/h2>\n

Your Right to Try<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ parallax=”on” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/ambrosecelltherapy.com\/contact\/” button_text=”Learn More” _builder_version=”3.19″ custom_button=”on” button_text_color=”#ffffff” button_border_width=”3px” button_border_color=”#ffffff” button_border_radius=”9px” button_letter_spacing=”2px” button_font=”Montserrat|on||on|” button_icon=”%%36%%” animation_style=”slide” button_text_color_hover=”#ffffff” button_border_color_hover=”#ffffff” button_letter_spacing_hover=”2px” button_bg_color_hover=”rgba(0,0,0,0)” saved_tabs=”all” locked=”off” button_text_size__hover_enabled=”off” button_text_size__hover=”null” button_one_text_size__hover_enabled=”off” button_one_text_size__hover=”null” button_two_text_size__hover_enabled=”off” button_two_text_size__hover=”null” button_text_color__hover_enabled=”on” button_text_color__hover=”#ffffff” button_one_text_color__hover_enabled=”off” button_one_text_color__hover=”null” button_two_text_color__hover_enabled=”off” button_two_text_color__hover=”null” button_border_width__hover_enabled=”off” button_border_width__hover=”null” button_one_border_width__hover_enabled=”off” button_one_border_width__hover=”null” button_two_border_width__hover_enabled=”off” button_two_border_width__hover=”null” button_border_color__hover_enabled=”on” button_border_color__hover=”#ffffff” button_one_border_color__hover_enabled=”off” button_one_border_color__hover=”null” button_two_border_color__hover_enabled=”off” button_two_border_color__hover=”null” button_border_radius__hover_enabled=”off” button_border_radius__hover=”null” button_one_border_radius__hover_enabled=”off” button_one_border_radius__hover=”null” button_two_border_radius__hover_enabled=”off” button_two_border_radius__hover=”null” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”2px” button_one_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover=”null” button_two_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover=”null” button_bg_color__hover_enabled=”on” button_bg_color__hover=”rgba(0,0,0,0.21)” button_one_bg_color__hover_enabled=”off” button_one_bg_color__hover=”null” button_two_bg_color__hover_enabled=”off” button_two_bg_color__hover=”null”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

In 2006, a group of researchers from Korea and Canada wrote a review paper covering a number of stem cell studies in small and large animals for spinal cord injury (SCI). They noted the potential for adult stem cell therapy to improve function in SCI patients. As the research has progressed, human trials using adult […]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[mk_page_section layout_structure=\"half_right\" bg_image=\"https:\/\/ambrosecelltherapy.com\/wp-content\/uploads\/2018\/11\/shutterstock_537411319.jpg\" bg_color=\"#1aa7aa\" min_height=\"500\" js_vertical_centered=\"true\" padding_top=\"0\" padding_bottom=\"0\"][vc_column][mk_fancy_title color=\"#ffffff\" size=\"37\" force_font_size=\"true\" size_phone=\"20\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" margin_bottom=\"30\" font_family=\"none\"]OUR BREAKTHROUGH IN STEM CELL THERAPY[\/mk_fancy_title][vc_column_text disable_pattern=\"false\" css=\".vc_custom_1541183975816{margin-bottom: 0px !important;}\"]We are leading the frontier to the innovation and discoveries. We are the first and only center in the US treating patients with our unique Ambrose Cell Thereapy.<\/span>[\/vc_column_text][\/vc_column][\/mk_page_section][vc_row][vc_column][mk_padding_divider size=\"80\"][\/vc_column][\/vc_row][vc_row][vc_column width=\"1\/6\"][\/vc_column][vc_column width=\"2\/3\"][mk_fancy_title color=\"#353535\" size=\"28\" force_font_size=\"true\" size_tablet=\"20\" size_phone=\"26\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" font_family=\"none\" align=\"center\"]what exactly is Ambrose Cell Therapy?[\/mk_fancy_title][vc_column_text align=\"center\" css=\".vc_custom_1541189399372{margin-bottom: 0px !important;}\"]Adult stem cell therapy is the process of isolating the stem and regenerative cells found in patients\u2019 own body fat and re-introducing them into damaged zones of the body and\/or systemically to address underlying factors of chronic, degenerative disease. Through minimally invasive adult stem cell therapy, \u00a0the body\u2019s own natural healing capabilities are put to work for each patient.<\/p>

To understand what stem cells are capable of first requires an understanding of a concept known as The Cycle of Disease. Although not all chronic disease is created equal with the same components, many share common denominators such as early inflammation, immune response, loss of blood supply, premature cell\/tissue death and resultant scarring.<\/p>

The treatment protocols of Okyanos are based on a thorough understanding of the multiple factors involved in each of the disease processes we treat. Stem cells have the unique advantage that they are able to address multiple aspects of the Cycle of Disease in a single treatment. Adult stem cells could be thought of as small physicians in the way that they go to work healing and repairing the body on a daily basis. Stem cells exist throughout our bodies and are responsible for healing our bumps and bruises and helping us recover from every day wear-and-tear.<\/p>

Restorative adult stem cells can be separated from your fat tissue and delivered to specific areas of the body in need of special attention. Because they have the capacity to detect issues\u00a0in the body which are causing pain or dysfunction, stem cells are able to respond and provide the correct \u201ctools\u201d needed for healing.[\/vc_column_text][mk_divider style=\"shadow_line\" margin_top=\"30\" margin_bottom=\"70\"][\/vc_column][vc_column width=\"1\/6\"][\/vc_column][\/vc_row][vc_row][vc_column width=\"1\/6\"][\/vc_column][vc_column width=\"2\/3\"][mk_fancy_title color=\"#353535\" size=\"28\" force_font_size=\"true\" size_tablet=\"20\" size_phone=\"26\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" font_family=\"none\" align=\"center\"]What sets Ambrose apart from other cell therapies?[\/mk_fancy_title][vc_column_text align=\"center\" css=\".vc_custom_1541185650115{margin-bottom: 0px !important;}\"]<\/p>

Our state-of-the-art facility is located in a government-regulated environment with routine oversight from regulators to ensure safety, and includes a Class C operating theater and Philips bi-plane cath lab for treating patients with cardiovascular disease and issues. Their team of doctors and medical staff include world-class physicians from each medical specialty including cardiology, orthopedics and neurology. These factors combine to make Ambrose a truly world-class cell therapy experience unlike anywhere else in the world that we are aware.<\/p>

[\/vc_column_text][\/vc_column][vc_column width=\"1\/6\"][\/vc_column][\/vc_row][vc_row][vc_column][mk_padding_divider][\/vc_column][\/vc_row][mk_page_section bg_color=\"#f8f8f8\" bg_repeat=\"no-repeat\" bg_stretch=\"true\" js_vertical_centered=\"true\" padding_top=\"60\" padding_bottom=\"60\" sidebar=\"sidebar-1\"][vc_column width=\"1\/6\"][\/vc_column][vc_column width=\"2\/3\"][mk_fancy_title color=\"#353535\" size=\"28\" force_font_size=\"true\" size_tablet=\"20\" size_phone=\"26\" font_weight=\"400\" txt_transform=\"capitalize\" letter_spacing=\"1\" margin_top=\"20\" font_family=\"none\" align=\"center\"]Frequently Asked Questions[\/mk_fancy_title][vc_accordions][vc_accordion_tab icon=\"mk-moon-user-8\" title=\"Who is a candidate for stem cell therapy?\"][vc_column_text align=\"center\" css=\".vc_custom_1541185911237{margin-bottom: 0px !important;}\"]<\/p>

Determining if a patient is a good candidate for treatment is a highly individualized process for each patient at Okyanos. The medical team will review each individual\u2019s medical records to determine whether cell therapy is appropriate for the condition at hand.<\/p>

Requirements:<\/strong><\/p>